Results 31 to 40 of about 124,392 (280)

Aberrant cerebellar Purkinje cell activity as the cause of motor attacks in a mouse model of episodic ataxia type 2

open access: yesDisease Models & Mechanisms, 2018
Many cerebellar-induced neurological disorders, such as ataxias and cerebellar-induced dystonias, are associated with abnormal Purkinje cell activity. In tottering mice, a well-established mouse model of episodic ataxia type 2 (EA2), cerebellar Purkinje ...
Esra Tara   +3 more
doaj   +1 more source

CRYPTOGENIC INCREASED ACTIVITY OF ASPARTATE AMINOTRANSFERASE: A CASE REPORT

open access: yesSlovenska pediatrija, 2021
We present a case of cryptogenic elevation of aspartate aminotransferase (AST) activity. AST is an enzyme found in many tissues, so the serum activity of this enzyme may be elevated in various diseases.
Tjaša Žagar, Rok Orel
doaj   +1 more source

A comment on "A fast L_p spike alignment metric" by A. J. Dubbs, B. A. Seiler and M. O. Magnasco [arXiv:0907.3137] [PDF]

open access: yes, 2009
Measuring the transmitted information in metric-based clustering has become something of a standard test for the performance of a spike train metric. In this comment, the recently proposed L_p Victor-Purpura metric is used to cluster spiking responses to
Houghton, Conor
core   +2 more sources

Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan   +17 more
wiley   +1 more source

Neuroblast Migration and P2Y Receptor Mediated Calcium Signalling Depend on 9-O-Acetyl GD3 Ganglioside

open access: yesASN Neuro, 2012
Previous studies indicated that a ganglioside 9acGD3 (9-O-acetyl GD3) antibody [the J-Ab (Jones antibody)] reduces GCP (granule cell progenitor) migration in vitro and in vivo . We here investigated, using cerebellar explants of postnatal day (P) 6 mice,
Marcelo F Santiago, Eliana Scemes
doaj   +1 more source

Tapering thrombopoietin receptor agonists in primary immune thrombocytopenia: Expert consensus based on the RAND/UCLA modified Delphi panel method

open access: yesResearch and Practice in Thrombosis and Haemostasis, 2021
Background Thrombopoietin receptor agonists (TPO‐RAs) are used to treat primary immune thrombocytopenia (ITP). Some patients have discontinued treatment while maintaining a hemostatic platelet count.
Adam Cuker   +13 more
doaj   +1 more source

Modern concepts of the platelet in health and disease [PDF]

open access: yes, 1962
Thesis (M.D.)--Boston ...
Estes, J. Worth
core  

A CASE OF PURPURA [PDF]

open access: yesJournal of the American Medical Association, 1909
In the following case I have regarded the condition as a distinct malady for descriptive purposes, since hemorrhages were the dominating feature. Symptoms of slight fever and weakness seemed not causative, but natural results respectively of ferment in the ecchymoses and loss of blood. Family History. —The patient's family consisted of father, mother
openaire   +2 more sources

GloPath: An Entity‐Centric Foundation Model for Glomerular Lesion Assessment and Clinicopathological Insights

open access: yesAdvanced Science, EarlyView.
An entity‐centric foundation model, GloPath, is introduced for comprehensive glomerular lesion assessment from routine renal biopsy images. Trained on over one million glomeruli, the framework enables robust lesion recognition, grading, and cross modality diag nosis, while uncovering large‐scale clinicopathological associations.
Qiming He   +28 more
wiley   +1 more source

Adult neurogenesis improves spatial information encoding in the mouse hippocampus

open access: yesNature Communications
Adult neurogenesis is a unique form of neuronal plasticity in which newly generated neurons are integrated into the adult dentate gyrus in a process that is modulated by environmental stimuli.
M. Agustina Frechou   +7 more
doaj   +1 more source

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