Results 41 to 50 of about 130,655 (306)

Pneumococcal purpura fulminans in asplenic or hyposplenic patients: a French multicenter exposed-unexposed retrospective cohort study

Critical Care, 2020
Background Pneumococcal infections remain the main cause of overwhelming post-splenectomy infections, and purpura fulminans may develop in almost 20% of patients with overwhelming post-splenectomy infection.
D. Contou, R. Coudroy, G. Colin, J. Tadié, M. Cour, R. Sonneville, A. Mekontso Dessap, N. de Prost, Laurent François Amélie Gaëtan Frédéric Pascal Pascal Cédr Argaud Barbier Bazire Béduneau Bellec Beuret Blanc, L. Argaud, F. Barbier, A. Bazire, G. Béduneau, F. Bellec, P. Beuret, P. Blanc, C. Bruel, C. Brun-Buisson, G. Colin, Delphine Colling, A. Conia, R. Coudroy, M. Cour, D. Contou, F. Daviaud, V. Das, J. Dellamonica, Nadège Demars, S. Ehrmann, A. Galbois, E. Gélisse, J. Grouille, L. Guérin, E. Guérot, S. Jaber, Caroline Jannière, S. Jochmans, M. Jozwiak, P. Kalfon, A. Kimmoun, A. Lautrette, J. Lemarié, C. Le Moal, C. Lenclud, N. Lerolle, O. Leroy, A. Marchalot, B. Mégarbane, A. Dessap, E. de Montmollin, F. Pène, C. Pichereau, G. Plantefeve, S. Préau, G. Preda, N. de Prost, J. Quenot, S. Ricôme, D. Roux, B. Sauneuf, M. Schmidt, G. Schnell, R. Sonneville, J. Tadié, Yacine Tandjaoui, M. Tchir, N. Terzi, X. Valette, L. Zafrani, B. Zuber   +69 more
semanticscholar   +1 more source

Sex-specific hypothalamic neural projection activity drives caregiving in mice

Nature Communications
Infant care is critical for survival and healthy development. In laboratory mice, unmated males and females display infant-directed behavior ranging from neglect and aggression to alloparental care.
Ilaria Carta, Tushar Arora, Stefano Lutzu, Giovanni Podda, Gaspar Nicolay Vera Ortega, Stephanie Rudolph, Anita E. Autry   +6 more
doaj   +1 more source

von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome.

New England Journal of Medicine, 1998
BACKGROUND Thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome are severe microvascular disorders of platelet clumping with similar signs and symptoms.
M. Furlan, R. Robles, M. Galbusera, G. Remuzzi, P. Kyrle, B. Brenner, M. Krause, I. Scharrer, V. Aumann, U. Mittler, M. Solenthaler, B. Lämmle   +11 more
semanticscholar   +1 more source

Use of PopPK and E‐R Analyses toward Explaining Causal Link Between ADAMTS13 in Recombinant vs. Plasma‐Based Therapies and Clinical Effects in cTTP

Clinical Pharmacology &Therapeutics, EarlyView.
Congenital thrombotic thrombocytopenic purpura (cTTP) is an ultra‐rare, potentially life‐threatening condition caused by a deficiency of the blood enzyme ADAMTS13. Until now, ADAMTS13 replacement has been achieved with infusions of plasma or plasma‐based therapies (PBT).
Munjal Patel, Huijuan Xu, Olivier Barriere, Paul Diderichsen, Parth Patwari, Andy Z. X. Zhu, Jean François Marier, Thomas Peyret, Linda T. Wang, Björn Mellgård, Wenping Wang, Indranil Bhattacharya   +11 more
wiley   +1 more source

Neuroblast Migration and P2Y Receptor Mediated Calcium Signalling Depend on 9-O-Acetyl GD3 Ganglioside

ASN Neuro, 2012
Previous studies indicated that a ganglioside 9acGD3 (9-O-acetyl GD3) antibody [the J-Ab (Jones antibody)] reduces GCP (granule cell progenitor) migration in vitro and in vivo . We here investigated, using cerebellar explants of postnatal day (P) 6 mice,
Marcelo F Santiago, Eliana Scemes
doaj   +1 more source

Aberrant cerebellar Purkinje cell activity as the cause of motor attacks in a mouse model of episodic ataxia type 2

Disease Models & Mechanisms, 2018
Many cerebellar-induced neurological disorders, such as ataxias and cerebellar-induced dystonias, are associated with abnormal Purkinje cell activity. In tottering mice, a well-established mouse model of episodic ataxia type 2 (EA2), cerebellar Purkinje ...
Esra Tara, Ariel Vitenzon, Ellen Hess, Kamran Khodakhah   +3 more
doaj   +1 more source

Balloon purpura

International Journal of Pediatrics and Adolescent Medicine, 2021
Valsalva maneuvers have the potential to cause dermal capillary rupture manifesting as purpura and petechiae. We present a unique case of Valsalva purpura occurring in a 12-year-old girl after blowing up multiple balloons at a birthday party.
Madray, Victoria M., Liner, Kendall R., Davis, Loretta S.   +2 more
openaire   +2 more sources

A phenomap of TTR amyloidosis to aid diagnostic screening

ESC Heart Failure, Volume 12, Issue 2, Page 1113-1118, April 2025.
Abstract Cardiac amyloidosis due to transthyretin (ATTR) remains an underdiagnosed cause of cardiomyopathy. As awareness of the disease grows and referrals for ATTR increase, clinicians are likely to encounter more atypical forms of the condition in clinical practice.
Alexios S. Antonopoulos, Theodoros Tsampras, George Lazaros, Konstantinos Tsioufis, Charalambos Vlachopoulos   +4 more
wiley   +1 more source

Adult neurogenesis improves spatial information encoding in the mouse hippocampus

Nature Communications
Adult neurogenesis is a unique form of neuronal plasticity in which newly generated neurons are integrated into the adult dentate gyrus in a process that is modulated by environmental stimuli.
M. Agustina Frechou, Sunaina S. Martin, Kelsey D. McDermott, Evan A. Huaman, Şölen Gökhan, Wolfgang A. Tomé, Ruben Coen-Cagli, J. Tiago Gonçalves   +7 more
doaj   +1 more source

Zshot: An Open-source Framework for Zero-Shot Named Entity Recognition and Relation Extraction [PDF]

Association for Computational Linguistics. 3 (2023) 357-368, 2023
The Zero-Shot Learning (ZSL) task pertains to the identification of entities or relations in texts that were not seen during training. ZSL has emerged as a critical research area due to the scarcity of labeled data in specific domains, and its applications have grown significantly in recent years.
arxiv