Results 191 to 200 of about 267,739 (297)

Laminar organization of pyramidal neuron cell types defines distinct CA1 hippocampal subregions. [PDF]

Nat Commun
Pachicano M, Mehta S, Hurtado A, Ard T, Stanis J, Breningstall B, Bienkowski MS.   +6 more
europepmc   +1 more source

New insights into epileptic spasm generation and treatment from the TTX animal model

Epilepsia Open, EarlyView.
Abstract Currently, we have an incomplete understanding of the mechanisms underlying infantile epileptic spasms syndrome (IESS). However, over the past decade, significant efforts have been made to develop IESS animal models to provide much‐needed mechanistic information for therapy development.
John W. Swann, Carlos J. Ballester‐Rosado, Chih‐Hong Lee   +2 more
wiley   +1 more source

Axon collateralization and focal myelin dystrophy alter action potential propagation in multicompartment pyramidal neuron models. [PDF]

PLoS Comput Biol
Sengupta N, Luebke JI, Weaver CM.
europepmc   +1 more source

CPP impairs contextual learning at concentrations below those that block pyramidal neuron NMDARs and LTP in the CA1 region of the hippocampus. [PDF]

Neuropharmacology, 2022
Laha K, Zhu M, Gemperline E, Rau V, Li L, Fanselow MS, Lennertz R, Pearce RA.   +7 more
europepmc   +1 more source

Real world testing and cost‐effectiveness analysis of subcutaneous EEG (REAL‐ASE): Protocol for a prospective multicentre interventional trial

Epilepsia Open, EarlyView.
Abstract Objective Epilepsy is a common condition associated with significant morbidity, mortality, and costs. Poor documentation of seizures is a major challenge in epilepsy care. Objective seizure counting with mobile devices may mitigate this challenge and improve patient management.
Matthew McWilliam, Pedro F. Viana, Eren Dursun, Joe Davies, Joel S. Winston, Jessica Agren, Harutomo Hasegawa, Jonas Duun‐Henriksen, Mark P. Richardson   +8 more
wiley   +1 more source

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

CA3 Pyramidal Neuron Activation Promotes Cognitive Resilience to Inflammation-Induced Cognitive Inflexibility. [PDF]

CNS Neurosci Ther
Zuo W, Fang S, Xu T, Li Y, Zhao J, Xie X, Wang T, Hou W, Wang M.   +8 more
europepmc   +1 more source

The Neuromuscular System Is Part of Brain Health

Brain Health, EarlyView.
Wolfgang Grisold
wiley   +1 more source

Epilepsy surgery: From bench to the clinics

Epilepsia Open, EarlyView.
Abstract Objective Recent advances in epilepsy surgery in patients with intractable epilepsy make it possible to study the mechanism of epilepsy in human brains. However, the true extent and propagation of each epileptogenic area from the epileptogenic focus in each patient is still difficult to perform “epilepsy cure” by surgery.
Tatsuya Tanaka
wiley   +1 more source

Frontal cortex pyramidal neuron expression profiles differentiate the prodromal stage from progressive degeneration across the Alzheimer's disease spectrum. [PDF]

Alzheimers Dement
Labuza A, Alldred MJ, Pidikiti H, Malek-Ahmadi MH, Lee SH, Heguy A, Coleman PD, Chakrabarty S, Chiosis G, Mufson EJ, Ginsberg SD.   +10 more
europepmc   +1 more source