Results 251 to 260 of about 63,189 (307)

Cyproheptadine Regulates Pyramidal Neuron Excitability in Mouse Medial Prefrontal Cortex. [PDF]

Neurosci Bull, 2018
He YL, Wang K, Zhao QR, Mei YA.
europepmc   +1 more source

Prevention of microglial activation and postoperative cognitive deficits by positive allosteric modulation of α5‐GABAA receptors

British Journal of Pharmacology, EarlyView.
Background and Purpose Long‐lasting cognitive deficits after surgery in aged individuals, referred to as perioperative neurocognitive disorder (NCD), are a significant public health concern. Such postoperative cognitive deficits are dependent on the presence of microglia in the brain, which, when activated, trigger neuroinflammation.
Jinrui Lyu, Rajasekar Nagarajan, Dishary Sharmin, Prithu Mondal, Maltesh Kambali, Muxiao Wang, Jinyan Zhou, Makoto Inoue, James M. Cook, Uwe Rudolph   +9 more
wiley   +1 more source

Differential polarization of cortical pyramidal neuron dendrites through weak extracellular fields. [PDF]

PLoS Comput Biol, 2018
Aspart F, Remme MWH, Obermayer K.
europepmc   +1 more source

Memantine prevents acute stress‐induced memory deficits by reversing sex‐dependent pathophysiological glutamatergic alterations in the dorsal hippocampus

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose The neural mechanisms underlying effects of acute stress on memory are poorly understood. We demonstrated previously that acute stress produces identical spatial memory deficits in male and female mice but through distinct molecular mechanisms, with females exhibiting up‐regulation of N‐methyl‐D‐aspartate (NMDA) receptor
Sebastiano A. Torrisi, Lidia Diolosà, Giuseppe Aceto, Claudia Marchetti, Federica Geraci, Konstantinos Partsinevelos, Silvia Rizzo, Margherita Grasso, Filippo Caraci, Francesco Bellia, Giovanni Li Volti, Angela Maria Amorini, Marcello D′Ascenzo, Gian Marco Leggio   +13 more
wiley   +1 more source

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) CM de Lange   +26 more
wiley   +1 more source

NePO: Neural Point Octrees for Large‐Scale Novel View Synthesis

Computer Graphics Forum, EarlyView.
We introduce Neural Point Octrees (NePOs), a scalable radiance field representation that organises point clouds hierarchically for efficient optimisation and rendering of large scale scenes. NePOs enable level of detail selection, joint refinement of appearance and camera poses, and real‐time rendering of hundreds of millions of points.
Noah Lewis, Darius Rückert, Marc Stamminger, Linus Franke   +3 more
wiley   +1 more source

A Survey of Methods for Constructing 3D Urban Models From Point Clouds

Computer Graphics Forum, EarlyView.
The survey outlines a general process for constructing 3D models from point clouds and categorizes the methods based on their use of templates, basic surface primitives, hybrid approaches, or linear primitives. Additionally, the survey reviews the datasets and benchmarks that are essential for testing and training the developed methods.
Chiara Romanengo, Silvia Biasotti, Bianca Falcidieno, Daniela Cabiddu, Elia Moscoso Thompson, Michela Spagnuolo   +5 more
wiley   +1 more source

A Real‐Time Multi‐Scale Neural Representation for Complex Surface Reflectance

Computer Graphics Forum, EarlyView.
Abstract Recent machine learning methods have significantly advanced the state of the art in the classic problem of representing surface appearance over angle, space, and scale. The models tend, however, to be relatively heavy compared to traditional fixed‐function representations, making real‐time application challenging.
Heikki Timonen, Pauli Kemppinen, Jaakko Lehtinen   +2 more
wiley   +1 more source

Differential impact of GABA _A receptors and gephyrin post-translational modifications on layer 2/3 pyramidal neuron responsiveness in vivo

, 2020
Tsai Y, Hleihil M, Otomo K, Abegg A, Cavaccini A, Panzanelli P, Cramer T, Ferrari KD, Barrett MJ, Bosshard G, Karayannis T, Weber B, Stobart JL, Tyagarajan SK.   +13 more
europepmc   +1 more source