Results 1 to 10 of about 153,466 (237)

The Subcortical-Allocortical- Neocortical continuum for the Emergence and Morphological Heterogeneity of Pyramidal Neurons in the Human Brain

Frontiers in Synaptic Neuroscience, 2021
Human cortical and subcortical areas integrate emotion, memory, and cognition when interpreting various environmental stimuli for the elaboration of complex, evolved social behaviors.
Alberto A. Rasia-Filho, Alberto A. Rasia-Filho, Kétlyn T. Knak Guerra, Carlos Escobar Vásquez, Aline Dall’Oglio, Roman Reberger, Cláudio R. Jung, Maria Elisa Calcagnotto, Maria Elisa Calcagnotto   +8 more
doaj   +1 more source

The time window for generation of dendritic spikes by coincidence of action potentials and EPSPs is layer specific in somatosensory cortex. [PDF]

PLoS ONE, 2012
The precise timing of events in the brain has consequences for intracellular processes, synaptic plasticity, integration and network behaviour. Pyramidal neurons, the most widespread excitatory neuron of the neocortex have multiple spike initiation zones,
Debora Ledergerber, Matthew Evan Larkum
doaj   +1 more source

Microglia-triggered hypoexcitability plasticity of pyramidal neurons in the rat medial prefrontal cortex

Current Research in Neurobiology, 2022
Lipopolysaccharide (LPS), an outer component of Gram-negative bacteria, induces a strong response of innate immunity via microglia, which triggers a modulation of the intrinsic excitability of neurons.
Yuki Yamawaki, Yayoi Wada, Sae Matsui, Gen Ohtsuki   +3 more
doaj   +1 more source

Interferon-γ acutely augments inhibition of neocortical layer 5 pyramidal neurons [PDF]

, 2020
BACKGROUND: Interferon-γ (IFN-γ, a type II IFN) is present in the central nervous system (CNS) under various conditions. Evidence is emerging that, in addition to its immunological role, IFN-γ modulates neuronal morphology, function, and development in ...
Bräuer, Anja U., Byvaltcev, Egor, Döhne, Noah, Grosser, Sabine, Janach, Gabriel M. S., Reetz, Olivia, Stadler, Konstantin, Strauss, Ulf   +7 more
core   +1 more source

The behavioral variant of Alzheimer’s disease does not show a selective loss of Von Economo and phylogenetically related neurons in the anterior cingulate cortex

Alzheimer’s Research & Therapy, 2022
Background The neurobiological origins of the early and predominant behavioral changes seen in the behavioral variant of Alzheimer’s disease (bvAD) remain unclear.
E. H. Singleton, Y. A. L. Pijnenburg, P. Gami-Patel, B. D. C. Boon, F. Bouwman, J. M. Papma, H. Seelaar, P. Scheltens, L. T. Grinberg, S. Spina, A. L. Nana, G. D. Rabinovici, W. W. Seeley, R. Ossenkoppele, A. A. Dijkstra   +14 more
doaj   +1 more source

An inhibitory pull-push circuit in frontal cortex. [PDF]

, 2017
Push-pull is a canonical computation of excitatory cortical circuits. By contrast, we identify a pull-push inhibitory circuit in frontal cortex that originates in vasoactive intestinal polypeptide (VIP)-expressing interneurons.
AA Zekveld, CK Pfeffer, CM Niell, D Huber, Dario L Ringach, DS Greenberg, Elaine Tring, HJ Pi, I Ozden, JJ Letzkus, Joshua T Trachtenberg, JS Anderson, L Petreanu, M Vinck, MJ McGinley, MM Karnani, Pablo Garcia-Junco-Clemente, PJ Mineault, PO Polack, RB Ebitz, RJ Douglas, S Lee, SL Smith, Taruna Ikrar, TW Chen, Xiangmin Xu, Y Fu   +26 more
core   +1 more source

Activation of functional α7-containing nAChRs in hippocampal CA1 pyramidal neurons by physiological levels of choline in the presence of PNU-120596.

PLoS ONE, 2010
BackgroundThe level of expression of functional α7-containing nicotinic acetylcholine receptors (nAChRs) in hippocampal CA1 pyramidal neurons is believed to be very low compared to hippocampal CA1 interneurons, and for many years this expression was ...
Bopanna I Kalappa, Alexander G Gusev, Victor V Uteshev   +2 more
doaj   +1 more source

Molecular dissection of I(A) in cortical pyramidal neurons reveals three distinct components encoded by Kv4.2, Kv4.3, and Kv1.4 alpha-subunits [PDF]

, 2010
The rapidly activating and inactivating voltage-gated K(+) (Kv) current, I(A), is broadly expressed in neurons and is a key regulator of action potential repolarization, repetitive firing, backpropagation (into dendrites) of action potentials, and ...
Nerbonne, Jeanne M, Norris, Aaron J
core   +2 more sources

The endogenous peptide antisecretory factor promotes tonic GABAergic signalling in CA1 stratum radiatum interneurons

Frontiers in Cellular Neuroscience, 2014
Tonic GABAergic inhibition regulates neuronal excitability and has been implicated to be involved in both neurological and psychiatric diseases. We have previously shown that the endogenous peptide antisecretory factor (AF) decreases phasic GABAergic ...
Joakim eStrandberg, Catarina eLindquist, Stefan eLange, Fredrik eAsztely, Eric eHanse   +4 more
doaj   +1 more source

Selective postnatal excitation of neocortical pyramidal neurons results in distinctive behavioral and circuit deficits in adulthood

iScience, 2021
Summary: In genetic and pharmacological models of neurodevelopmental disorders, and human data, neural activity is altered within the developing neocortical network. This commonality begs the question of whether early enhancement in excitation might be a
William E. Medendorp, Andreas Bjorefeldt, Emmanuel L. Crespo, Mansi Prakash, Akash Pal, Madison L. Waddell, Christopher I. Moore, Ute Hochgeschwender   +7 more
doaj   +1 more source