Reduced Cortical Pyramidal Neuron Membrane Excitability and Synaptic Function in Parkinsonian Mice and Their Restoration by L-Dopa Treatment: Indirect Mediation by Striatal Dopaminergic Activity [PDF]
Brain SciencesBackground: We previously established that striatal, but not cortical, dopaminergic activation stimulates movement, indicating that the crucial and original site of dopaminergic stimulation of motor function is the striatum, not the motor cortex.
Huimin Chen +4 more
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Optogenetic Stimulation of Prelimbic Pyramidal Neurons Maintains Fear Memories and Modulates Amygdala Pyramidal Neuron Transcriptome. [PDF]
Int J Mol Sci, 2021 Fear extinction requires coordinated neural activity within the amygdala and medial prefrontal cortex (mPFC). Any behavior has a transcriptomic signature that is modified by environmental experiences, and specific genes are involved in functional plasticity and synaptic wiring during fear extinction.
Laricchiuta D +15 more
europepmc +6 more sources
Thalamocortical feedback selectively controls pyramidal neuron excitability [PDF]
Nature CommunicationsThe apical dendrites of layer (L) 2/3 pyramidal neurons in the mouse somatosensory cortex integrate synaptic input from long-range projections. Among those, inputs from the higher-order thalamic posteromedial nucleus may facilitate sensory-evoked ...
Federico Brandalise +9 more
doaj +2 more sources
Action potential modulation in CA1 pyramidal neuron axons facilitates OLM interneuron activation in recurrent inhibitory microcircuits of rat hippocampus. [PDF]
PLoS ONE, 2014 Oriens-lacunosum moleculare (O-LM) interneurons in the CA1 region of the hippocampus play a key role in feedback inhibition and in the control of network activity. However, how these cells are efficiently activated in the network remains unclear.
Sooyun Kim
doaj +3 more sources
Anatomy and physiology of the thick-tufted layer 5 pyramidal neuron
Frontiers in Cellular Neuroscience, 2015 The thick-tufted layer 5 (TTL5) pyramidal neuron is one of the most extensively studied neuron types in the mammalian neocortex and has become a benchmark for understanding information processing in excitatory neurons.
Srikanth Ramaswamy +2 more
exaly +3 more sources
Input transformation by dendritic spines of pyramidal neurons [PDF]
Frontiers in Neuroanatomy, 2014 In the mammalian brain, most inputs received by a neuron are formed on the dendritic tree. In the neocortex, the dendrites of pyramidal neurons are covered by thousands of tiny protrusions known as dendritic spines, which are the major recipient sites ...
Roberto eAraya
doaj +3 more sources
Inferring Pyramidal Neuron Morphology using EAP Data [PDF]
Int IEEE EMBS Conf Neural Eng, 2023 Satish S Nair
exaly +2 more sources
Pyramidal neuron morphogenesis requires a septin network that stabilizes filopodia and suppresses lamellipodia during neurite initiation [PDF]
Current Biology, 2023 Megan R Radler +2 more
exaly +2 more sources
Frontiers in Computational Neuroscience, 2023 Alzheimer's disease (AD) is a progressive memory loss and cognitive dysfunction brain disorder brought on by the dysfunctional amyloid precursor protein (APP) processing and clearance of APP peptides.
Justinas J. Dainauskas +7 more
doaj +1 more source
Dendritic Properties of Turtle Pyramidal Neurons [PDF]
Journal of Neurophysiology, 2008 The six-layered mammalian neocortex evolved from the three-layered paleocortex, which is retained in present-day reptiles such as the turtle. Thus the turtle offers an opportunity to examine which cellular and circuit properties are fundamental to cortical function.
Larkum, Matthew +4 more
openaire +4 more sources