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General Anesthesia Decouples Cortical Pyramidal Neurons [PDF]
Cell, 2020 The mystery of general anesthesia is that it specifically suppresses consciousness by disrupting feedback signaling in the brain, even when feedforward signaling and basic neuronal function are left relatively unchanged. The mechanism for such selectiveness is unknown.
Matthew Larkum, Mototaka Suzuki
exaly +3 more sources
Input transformation by dendritic spines of pyramidal neurons [PDF]
Frontiers in Neuroanatomy, 2014 In the mammalian brain, most inputs received by a neuron are formed on the dendritic tree. In the neocortex, the dendrites of pyramidal neurons are covered by thousands of tiny protrusions known as dendritic spines, which are the major recipient sites ...
Roberto eAraya
doaj +3 more sources
Optogenetic Stimulation of Prelimbic Pyramidal Neurons Maintains Fear Memories and Modulates Amygdala Pyramidal Neuron Transcriptome [PDF]
International Journal of Molecular Sciences, 2021 Fear extinction requires coordinated neural activity within the amygdala and medial prefrontal cortex (mPFC). Any behavior has a transcriptomic signature that is modified by environmental experiences, and specific genes are involved in functional plasticity and synaptic wiring during fear extinction.
Daniela Laricchiuta +15 more
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Action potential modulation in CA1 pyramidal neuron axons facilitates OLM interneuron activation in recurrent inhibitory microcircuits of rat hippocampus. [PDF]
PLoS ONE, 2014 Oriens-lacunosum moleculare (O-LM) interneurons in the CA1 region of the hippocampus play a key role in feedback inhibition and in the control of network activity. However, how these cells are efficiently activated in the network remains unclear.
Sooyun Kim
doaj +1 more source
Frontiers in Computational Neuroscience, 2023 Alzheimer's disease (AD) is a progressive memory loss and cognitive dysfunction brain disorder brought on by the dysfunctional amyloid precursor protein (APP) processing and clearance of APP peptides.
Justinas J. Dainauskas +7 more
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Dendritic Properties of Turtle Pyramidal Neurons [PDF]
Journal of Neurophysiology, 2008 The six-layered mammalian neocortex evolved from the three-layered paleocortex, which is retained in present-day reptiles such as the turtle. Thus the turtle offers an opportunity to examine which cellular and circuit properties are fundamental to cortical function.
Larkum, Matthew +4 more
openaire +4 more sources
Molecular Brain, 2021 The ACC is an important brain area for the processing of pain-related information. Studies of synaptic connections within the ACC provide an understanding of basic cellular and molecular mechanisms for brain functions such as pain, emotion and related ...
Jung-Hyun Alex Lee +4 more
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Fractional differentiation by neocortical pyramidal neurons [PDF]
Nature Neuroscience, 2008 Neural systems adapt to changes in stimulus statistics. However, it is not known how stimuli with complex temporal dynamics drive the dynamics of adaptation and the resulting firing rate. For single neurons, it has often been assumed that adaptation has a single time scale.
Lundstrom, Brian Nils +3 more
openaire +2 more sources
Cholinergic Inhibition of Neocortical Pyramidal Neurons [PDF]
The Journal of Neuroscience, 2005 Acetylcholine (ACh) is a central neurotransmitter critical for normal cognitive function. Here we show that transient muscarinic acetylcholine receptor activation directly inhibits neocortical layer 5 pyramidal neurons. Using whole-cell and cell-attached recordings from neurons in slices of rat somatosensory cortex, we demonstrate that transient ...
Gulledge, Allan T, Stuart, Gregory J
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Analysis of Mouse Brain Sections by Live-cell Time-lapse Confocal Microscopy
Bio-Protocol, 2023 The developing cerebral cortex of mammals is generated from nascent pyramidal neurons, which radially migrate from their birthplace in the ventral part of the neural tube to the cortical surface.
Tao Yang, Ty Hergenreder, Bing Ye
doaj +1 more source