Results 41 to 50 of about 63,189 (307)

NPTX2 and cognitive dysfunction in Alzheimer’s Disease

eLife, 2017
Memory loss in Alzheimer’s disease (AD) is attributed to pervasive weakening and loss of synapses. Here, we present findings supporting a special role for excitatory synapses connecting pyramidal neurons of the hippocampus and cortex with fast-spiking ...
Mei-Fang Xiao, Desheng Xu, Michael T Craig, Kenneth A Pelkey, Chun-Che Chien, Yang Shi, Juhong Zhang, Susan Resnick, Olga Pletnikova, David Salmon, James Brewer, Steven Edland, Jerzy Wegiel, Benjamin Tycko, Alena Savonenko, Roger H Reeves, Juan C Troncoso, Chris J McBain, Douglas Galasko, Paul F Worley   +19 more
doaj   +1 more source

The “psychiatric” neuron: the psychic neuron of the cerebral cortex, revisited

Frontiers in Human Neuroscience
Nearly 25 years ago, Dr. Patricia Goldman-Rakic published her review paper, “The ‘Psychic’ Neuron of the Cerebral Cortex,” outlining the circuit-level dynamics, neurotransmitter systems, and behavioral correlates of pyramidal neurons in the cerebral ...
L. Taylor Flynn, L. Taylor Flynn, Nadia N. Bouras, Volodar M. Migovich, Jacob D. Clarin, Wen-Jun Gao   +5 more
doaj   +1 more source

Double trouble? Potential for hyperexcitability following both channelopathic up- and downregulation of I_h in epilepsy

Frontiers in Neuroscience, 2009
Studies of pathological ion channel regulation as an underlying mechanism of epilepsy have revealed alterations of the h-current in several animal models.
Jonas Dyhrfjeld-Johnsen, Jonas Dyhrfjeld-Johnsen, Robert J Morgan, Ivan Soltesz   +3 more
doaj   +1 more source

Automated analysis of spine dynamics on live CA1 pyramidal cells [PDF]

, 2015
Dendritic spines may be tiny in volume, but are of major importance for neuroscience. They are the main receivers for excitatory synaptic connections, and their constant changes in number and in shape reflect the dynamic connectivity of the brain.
Vetter, Thomas, Oertner, Thomas G., Genoud, Christel, Blumer, Clemens, Perez-Alvarez, Alberto, Vivien, Cyprien, Wiegert, J. Simon   +6 more
core   +1 more source

Neuroscience Jokes. Pyramidal Neurons

, 2023
Short book with educative jokes, to make us think and remember aspects of pyramidal function and connectivity we still dont fully understand.
delgado ruz, isabel, chadderton, Paul
openaire   +1 more source

Automated optimization of a reduced layer 5 pyramidal cell model based on experimental data.

, 2012
The construction of compartmental models of neurons involves tuning a set of parameters to make the model neuron behave as realistically as possible.
Herz, AV, Stemmler, MB, Bahl, A, Stemmler, M., Roth, A., Roth, A, Herz, A., Bahl, A.   +7 more
core   +1 more source

Computational Modeling of Genetic Contributions to Excitability and Neural Coding in Layer V Pyramidal Cells: Applications to Schizophrenia Pathology

Frontiers in Computational Neuroscience, 2019
Pyramidal cells in layer V of the neocortex are one of the most widely studied neuron types in the mammalian brain. Due to their role as integrators of feedforward and cortical feedback inputs, they are well-positioned to contribute to the symptoms and ...
Tuomo Mäki-Marttunen, Anna Devor, Anna Devor, Anna Devor, William A. Phillips, Anders M. Dale, Anders M. Dale, Ole A. Andreassen, Gaute T. Einevoll, Gaute T. Einevoll   +9 more
doaj   +1 more source

Pyramidal Neurons Grow Up and Change Their Mind [PDF]

Neuron, 2008
The precise stereotypic projections of pyramidal neurons within the six-layered cortex of mammals are key in allowing this structure to attain its high level of function. Recent studies have provided the first indications that postmitotic transcription factors are required for the formation and maintenance of both corticofugal and intracortical ...
Fishell, Gord, Hanashima, Carina
openaire   +2 more sources

Correction of conductance measurements in non-space-clamped structures: 1. Voltage-gated K+ channels

, 2003
To understand functions of a single neuron, such as propagation and generation of synaptic or action potentials, a detailed description of the kinetics and distribution of the underlying ionic conductances is essential.
Korngreen, A, Helmstaedter, M., Helmstaedter, Moritz, Schaefer, AT, Korngreen, A., Schaefer, A., Sakmann, Bert, Helmstaedter, M, Sakmann, B, Schaefer, Andreas T., Korngreen, Alon, Sakmann, B., Helmstädter, Moritz   +12 more
core   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source