Results 51 to 60 of about 63,189 (307)

VIP interneurons in mouse primary visual cortex selectively enhance responses to weak but specific stimuli

eLife, 2020
Vasoactive intestinal peptide-expressing (VIP) interneurons in the cortex regulate feedback inhibition of pyramidal neurons through suppression of somatostatin-expressing (SST) interneurons and, reciprocally, SST neurons inhibit VIP neurons. Although VIP
Daniel J Millman, Gabriel Koch Ocker, Shiella Caldejon, India Kato, Josh D Larkin, Eric Kenji Lee, Jennifer Luviano, Chelsea Nayan, Thuyanh V Nguyen, Kat North, Sam Seid, Cassandra White, Jerome Lecoq, Clay Reid, Michael A Buice, Saskia EJ de Vries   +15 more
doaj   +1 more source

Exact firing-rate response of the integrate-and-fire neuron receiving finite amplitude excitatory and inhibitory post-synaptic potentials [PDF]

, 2011
Neurons in active networks are subject to a fluctuating synaptic drive comprising excitatory and inhibitory postsynaptic potentials arriving at high rates relative to the integration time of the cell.
Swarbrick, Rupert, Richardson, Magnus J. E., Richardson Magnus JE, Rupert Swarbrick, Swarbrick Rupert, Magnus JE Richardson   +5 more
core   +1 more source

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe, Keizo Sugaya, Kentaro Hayashi, Keiko Hino, Yasuhiro Nakata, Kota Bokuda, Toshio Shimizu, Kazushi Takahashi   +7 more
wiley   +1 more source

Atypical hippocampal excitatory neurons express and govern object memory

Nature Communications
Classically, pyramidal cells of the hippocampus are viewed as flexibly representing spatial and non-spatial information. Recent work has illustrated distinct types of hippocampal excitatory neurons, suggesting that hippocampal representations and ...
Adrienne I. Kinman, Derek N. Merryweather, Sarah R. Erwin, Regan E. Campbell, Kaitlin E. Sullivan, Larissa Kraus, Margarita Kapustina, Brianna N. Bristow, Mingjia Y. Zhang, Madeline W. Elder, Sydney C. Wood, Ali Tarik, Esther Kim, Joshua Tindall, William Daniels, Mehwish Anwer, Caiying Guo, Mark S. Cembrowski   +17 more
doaj   +1 more source

Neural Coding and Feature Extraction of Time-Varying Signals [PDF]

, 2002
What are the neuronal codes that the brain uses to represent information? This constitutes one of the most fascinating and challenging questions in Neuroscience.
Kreiman, Gabriel Alejandro
core   +1 more source

Prominent Movement Disorders in RNU2‐2‐Related Spliceosomopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Pediatric movement disorders often overlap with neurodevelopmental diseases, suggesting shared molecular mechanisms. Variants in small nuclear RNA (snRNA) genes encoding spliceosome components have recently been associated with neurodevelopmental disorders, termed “RNUopathies.” We analyzed genome sequencing data from 14 patients with ...
Magdalena Krygier, Ugo Sorrentino, Matias Wagner, Marta Zawadzka, Anna Lemska, Maria Mazurkiewicz‐Bełdzińska, Michael Zech   +6 more
wiley   +1 more source

The plasticity of pyramidal neurons in the behaving brain

Philosophical Transactions of the Royal Society B: Biological Sciences
Neurons are plastic. That is, they change their activity according to different behavioural conditions. This endows pyramidal neurons with an incredible computational power for the integration and processing of synaptic inputs. Plasticity can be investigated at different levels of investigation within a single neuron, from spines to ...
Elena Regele-Blasco, Lucy M. Palmer
openaire   +3 more sources

Key morphological features of human pyramidal neurons

Cerebral Cortex, 2023
Abstract The basic building block of the cerebral cortex, the pyramidal cell, has been shown to be characterized by a markedly different dendritic structure among layers, cortical areas, and species. Functionally, differences in the structure of their dendrites and axons are critical in determining how neurons integrate information ...
Benavides Piccione, Ruth, Blázquez Llorca, Lidia, Kastanauskaite, Asta, Fernaud Espinosa, Isabel, Tapia González, Silvia, Felipe Oroquieta, Javier de   +5 more
openaire   +4 more sources

Microgel‐Based 3D Bioprinting: A Convergent Strategy Integrating Material Design, Jamming Dynamics, and Biological Function

Advanced Healthcare Materials, EarlyView.
Microgel‐based 3D printed constructs represent a compelling and versatile innovation for engineering architecturally complex, dynamically remodelable, and biocompatible structures with high structural fidelity and bioactivity. By integrating material design, biofabrication, and biological function, these systems enable the development of adaptive ...
Elena Ghighină, Andreea Ioana Dinu, Jana Ghițman   +2 more
wiley   +1 more source

Autapses enhance bursting and coincidence detection in neocortical pyramidal cells

Nature Communications, 2018
While autapses are synapses made by a neuron onto itself, its functional significance in pyramidal cells are not clear. Here, the authors show that in the mammalian neocortex, autapses of pyramidal cells can enhance burst firing and coincidence detection
Luping Yin, Rui Zheng, Wei Ke, Quansheng He, Yi Zhang, Junlong Li, Bo Wang, Zhen Mi, Yue-sheng Long, Malte J. Rasch, Tianfu Li, Guoming Luan, Yousheng Shu   +12 more
doaj   +1 more source