Results 71 to 80 of about 63,189 (307)
Location-dependent excitatory synaptic interactions in pyramidal neuron dendrites. [PDF]
PLoS Computational Biology, 2012 Neocortical pyramidal neurons (PNs) receive thousands of excitatory synaptic contacts on their basal dendrites. Some act as classical driver inputs while others are thought to modulate PN responses based on sensory or behavioral context, but the ...
Bardia F Behabadi +4 more
doaj +1 more source
Coevolution in the timing of GABAergic and pyramidal neuron maturation in primates. [PDF]
Proc Biol Sci, 2017 The cortex of primates is relatively expanded compared with many other mammals, yet little is known about what developmental processes account for the expansion of cortical subtype numbers in primates, including humans.
Charvet CJ +9 more
europepmc +2 more sources
Advanced Science, EarlyView.Fibronectin 1 (FN1)‐expressing subicular subpopulations encode novel object preference and selectively govern retrieval of novel object recognition (NOR) via affecting excitability of entorhinal‐projecting circuit through large conductance Ca2+‐activated potassium (BK) channel. ABSTRACT Novel object recognition (NOR), referring to the cognitive ability
Fan Fei +15 more
wiley +1 more source
Distinguishing linear vs. nonlinear integration in CA1 radial oblique dendrites: it’s about time
Frontiers in Computational Neuroscience, 2011 It was recently shown that multiple excitatory inputs to CA1 pyramidal neuron dendrites must be activated nearly simultaneously to generate local dendritic spikes and superlinear responses at the soma; even slight input desynchronization prevented local ...
José Francisco eGómez González +2 more
doaj +1 more source
Advanced Science, EarlyView.Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng +8 more
wiley +1 more source
Pinpointing Morphology and Projection of Excitatory Neurons in Mouse Visual Cortex
Frontiers in Neuroscience, 2019 The excitatory neurons in the visual cortex are of great significance for us in understanding brain functions. However, the diverse neuron types and their morphological properties have not been fully deciphered.
Yalun Zhang +21 more
doaj +1 more source
Signal integration on the dendrites of a pyramidal neuron model [PDF]
Cognitive Neurodynamics, 2013 This paper studied the synaptic and dendritic integration with different spatial distributions of synapses on the dendrites of a biophysically-detailed layer 5 pyramidal neuron model. It has been observed that temporally synchronous and spatially clustered synaptic inputs make dendrites perform a highly nonlinear integration.
openaire +2 more sources
, 2011 The goal of this paper is twofold. We propose and explore a model to study the synchronization among populations in the canonical model of the neocortex proposed previously by (R.J. Douglas, K.A.C. Martin, A functional microcircuit for cat visual cortex.
Roberto Carlos Sotero Diaz +2 more
core +1 more source
Advanced Science, EarlyView.An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu +11 more
wiley +1 more source
Remarks on the number of tubulin dimers per neuron and implications for Hameroff-Penrose Orch OR
, 2009 Stuart Hameroff has wrongly estimated that a typical brain neuron has 10^7^ tubulin dimers and wrongly attributed this result to Yu and Baas, J. Neurosci. 1994; 14: 2818-2829.
Danko Georgiev
core +1 more source