Pyramidal neuron subtype diversity governs microglia states in the neocortex [PDF]
Nature, 2022 Microglia are macrophages of the brain parenchyma that exist in multiple transcriptional states and reside within a wide range of neuronal environments. However, it is poorly understood how and where these states are generated.
Arlotta, Paola +11 more
core +2 more sources
Reduced Cortical Pyramidal Neuron Membrane Excitability and Synaptic Function in Parkinsonian Mice and Their Restoration by L-Dopa Treatment: Indirect Mediation by Striatal Dopaminergic Activity [PDF]
Brain SciencesBackground: We previously established that striatal, but not cortical, dopaminergic activation stimulates movement, indicating that the crucial and original site of dopaminergic stimulation of motor function is the striatum, not the motor cortex.
Huimin Chen +4 more
doaj +2 more sources
Thalamocortical feedback selectively controls pyramidal neuron excitability [PDF]
Nature CommunicationsThe apical dendrites of layer (L) 2/3 pyramidal neurons in the mouse somatosensory cortex integrate synaptic input from long-range projections. Among those, inputs from the higher-order thalamic posteromedial nucleus may facilitate sensory-evoked ...
Federico Brandalise +9 more
doaj +2 more sources
The “psychiatric” neuron: the psychic neuron of the cerebral cortex, revisited [PDF]
Frontiers in Human NeuroscienceNearly 25 years ago, Dr. Patricia Goldman-Rakic published her review paper, “The ‘Psychic’ Neuron of the Cerebral Cortex,” outlining the circuit-level dynamics, neurotransmitter systems, and behavioral correlates of pyramidal neurons in the cerebral ...
L. Taylor Flynn +5 more
doaj +2 more sources
Protocol for quantifying pyramidal neuron hyperexcitability in a mouse model of neurodevelopmental encephalopathy [PDF]
STAR ProtocHere, we present a protocol for quantifying pyramidal neuron hyperexcitability in a mouse model of STXBP1 neurodevelopmental encephalopathy (Stxbp1hap). We describe steps for preparing brain slices, positioning electrodes, and performing an excitability ...
Gomez, Carlos Daniel +6 more
core +2 more sources
Computational Modeling of Genetic Contributions to Excitability and Neural Coding in Layer V Pyramidal Cells: Applications to Schizophrenia Pathology [PDF]
Frontiers in Computational Neuroscience, 2019 Pyramidal cells in layer V of the neocortex are one of the most widely studied neuron types in the mammalian brain. Due to their role as integrators of feedforward and cortical feedback inputs, they are well-positioned to contribute to the symptoms and ...
Tuomo Mäki-Marttunen +9 more
doaj +2 more sources
Coevolution in the timing of GABAergic and pyramidal neuron maturation in primates [PDF]
Proc Biol Sci, 2017 The cortex of primates is relatively expanded compared with many other mammals, yet little is known about what developmental processes account for the expansion of cortical subtype numbers in primates, including humans.
Goran Šimić +9 more
core +2 more sources
Anatomy and Physiology of the Thick-tufted Layer 5 Pyramidal Neuron [PDF]
Frontiers in Cellular Neuroscience, 2015 The thick-tufted layer 5 (TTL5) pyramidal neuron is one of the most extensively studied neuron types in the mammalian neocortex and has become a benchmark for understanding information processing in excitatory neurons.
Srikanth eRamaswamy, Henry eMarkram
doaj +3 more sources
Stereology neuron counts correlate with deep learning estimates in the human hippocampal subregions
Scientific Reports, 2023 Hippocampal subregions differ in specialization and vulnerability to cell death. Neuron death and hippocampal atrophy have been a marker for the progression of Alzheimer’s disease.
Jan Oltmer +8 more
doaj +1 more source
Neurons as Canonical Correlation Analyzers
Frontiers in Computational Neuroscience, 2020 Normative models of neural computation offer simplified yet lucid mathematical descriptions of murky biological phenomena. Previously, online Principal Component Analysis (PCA) was used to model a network of single-compartment neurons accounting for ...
Cengiz Pehlevan +4 more
doaj +1 more source