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GM2 ganglioside and pyramidal neuron dendritogenesis
Neurochemical Research, 1995GM2 ganglioside, although scarce in normal adult brain, is the predominant ganglioside accumulating in several types of lysosomal disorders, most notably Tay-Sachs disease. Pyramidal neurons of cerebral cortex in Tay-Sachs, as well as many other types of neuronal storage disorders, are known to exhibit a phenomenon believed unique to storage disorders:
S U, Walkley, D A, Siegel, K, Dobrenis
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Inferring Pyramidal Neuron Morphology using EAP Data
2023 11th International IEEE/EMBS Conference on Neural Engineering (NER), 2023We report a computational algorithm that uses an inverse modeling scheme to infer neuron position and morphology of cortical pyramidal neurons using spatio-temporal extracellular action potential recordings.. We first develop a generic pyramidal neuron model with stylized morphology and active channels that could mimic the realistic ...
Ziao, Chen +2 more
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Insulin inhibits pyramidal neurons in hippocampal slices
Brain Research, 1984Recent studies have confirmed the presence of insulin receptors in the rat brain although their function has still not been well defined. The present study explores the possibility that insulin receptors in the brain can alter or contribute to central neurotransmission. Insulin caused a dose-dependent inhibition of hippocampal pyramidal neurons.
Palovcik, Reinhard A. +3 more
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Simulations of Intrinsically Bursting Neocortical Pyramidal Neurons
Neural Computation, 1994Neocortical layer 5 intrinsically bursting (IB) pyramidal neurons were simulated using compartment model methods. Morphological data as well as target neurophysiological responses were taken from a series of published studies on the same set of rat visual cortex pyramidal neurons (Mason, A. and Larkman, A. J., 1990. J. Neurosci.
Rhodes, Paul A., Gray, Charles M.
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Acetylcholinesterase-rich pyramidal neurons in alzheimer's disease
Neurobiology of Aging, 1992The distribution of acetylcholinesterase (AChE)-rich pyramidal neurons was studied in the cortices of 7 Alzheimer's Disease (AD) patients and 4 normal-aged subjects. Both groups showed a characteristic distribution of these neurons with the highest density in motor and premotor areas, moderate density in association cortices, and low density in limbic ...
S, Heckers, C, Geula, M M, Mesulam
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Acetylcholine induced modulation of hippocampal pyramidal neurons
Brain Research, 1981Applications of acetylcholine to hippocampal slices maintained in vitro resulted in slow depolarizations and simultaneous increases in membrane resistance (RN)in hippocampal pyramidal neurons. Increases in RN had both voltage dependent and voltage independent components.
L S, Benardo, D A, Prince
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Active Properties of Neocortical Pyramidal Neuron Dendrites
Annual Review of Neuroscience, 2013Dendrites are the main recipients of synaptic inputs and are important sites that determine neurons' input-output functions. This review focuses on thin neocortical dendrites, which receive the vast majority of synaptic inputs in cortex but also have specialized electrogenic properties.
Guy, Major +2 more
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Mechanisms of axon polarization in pyramidal neurons
Molecular and Cellular Neuroscience, 2020Neurons are highly polarized cells that have specialized regions for synaptic input, the dendrites, and synaptic output, the axons. This polarity is critical for appropriate neural circuit formation and function. One of the central gaps in our knowledge is understanding how developing neurons initiate axon polarity.
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