Results 11 to 20 of about 153,466 (237)
Pharmaco-genetic therapeutics targeting parvalbumin neurons attenuate temporal lobe epilepsy
Neurobiology of Disease, 2018 Temporal lobe epilepsy (TLE) is the most common type of epilepsy and is often medically refractory. Previous studies suggest that selective pharmaco-genetic inhibition of pyramidal neurons has therapeutic value for the treatment of epilepsy, however ...
Ying Wang +13 more
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New insights into the classification and nomenclature of cortical GABAergic interneurons. [PDF]
, 2013 A systematic classification and accepted nomenclature of neuron types is much needed but is currently lacking. This article describes a possible taxonomical solution for classifying GABAergic interneurons of the cerebral cortex based on a novel, web ...
A Karagiannis +82 more
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Cell Reports, 2023 Summary: Fear-related disorders arise from inefficient fear extinction and have immeasurable social and economic costs. Here, we characterize mouse phenotypes that spontaneously show fear-independent behavioral traits predicting adaptive or maladaptive ...
Daniela Laricchiuta +16 more
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IK1 channels do not contribute to the slow afterhyperpolarization in pyramidal neurons
eLife, 2016 In pyramidal neurons such as hippocampal area CA1 and basolateral amygdala, a slow afterhyperpolarization (sAHP) follows a burst of action potentials, which is a powerful regulator of neuronal excitability. The sAHP amplitude increases with aging and may
Kang Wang +9 more
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Frontiers in Pharmacology, 2022 There is ongoing dispute on the question whether CNS neurons possess ATP-sensitive P2X7 receptors (Rs) or whether only non-neuronal cells bear this receptor-type and indirectly signal to the neighboring neurons. We genetically deleted P2X7Rs specifically
Ying Zhang +9 more
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A modelling study of beta-amyloid induced change in hippocampal theta rhythm [PDF]
, 2011 Many dementia cases, such as Alzheimer’s disease (AD), are characterized by an increase in low frequency field potential oscillations. However, a definitive understanding of the effects of the beta-Amyloid peptide, which is a main marker of AD, on
Damien Coyle +3 more
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Glutamate receptor expression and chronic glutamate toxicity in rat motor cortex
Neurobiology of Disease, 2007 In addition to the loss of spinal motor neurons, amyotrophic lateral sclerosis (ALS) is also associated with degeneration of corticospinal layer V pyramidal neurons and decreased glutamate transport in the cortex. We characterized the glutamate receptors
Kate C. Young +2 more
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Morphometric characteristics of the neurons of the human subiculum proper [PDF]
Archives of Biological Sciences, 2012 The human subiculum is a significant part of the hippocampal formation positioned between the hippocampus proper and the entorhinal and other cortices.
Živanović-Mačužić Ivana +7 more
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Why Neurons Have Thousands of Synapses, A Theory of Sequence Memory in Neocortex [PDF]
, 2015 Neocortical neurons have thousands of excitatory synapses. It is a mystery how neurons integrate the input from so many synapses and what kind of large-scale network behavior this enables.
Ahmad, Subutai, Hawkins, Jeff
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Effect of temperature on spiking patterns of neocortical layer 2/3 and layer 6 pyramidal neurons
Frontiers in Neural Circuits, 2012 The spiking patterns of neocortical pyramidal neurons are shaped by the conductances in their apical dendrites. We have previously shown that the spiking patterns of layer 5 pyramidal neurons change with temperature, probably because temperature ...
Jack eWaters, Tristan eHedrick
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