Results 11 to 20 of about 14,524 (254)

Deuteration of Six-Membered N-Heteroarenes: Chemistry and Applications. [PDF]

Chemistry
Deuterated six‐membered N‐Heteroarenes (6NHetAr) are finding utility in an increasing repertoire of applications. Our paper comprehensively reviews synthetic approaches that have been reported for the deuteration of 6NHetAr and their fused counterparts while providing an overview of established and emerging applications for these materials.
Raju L, Tiz DB, Iles A, Košmrlj J, Jansen-van Vuuren RD.   +4 more
europepmc   +2 more sources

Photoinduced, Chemoselective γ-Alkylation of 2-Silyloxyfurans With α-Bromoketones: A Rapid Entry to Chiral ε-Keto-γ-Butenolides. [PDF]

Chemistry
A photoinduced, regio‐ and chemoselective γ‐alkylation of 2‐silyloxyfurans with a‐bromoketones was achieved by exploiting a photoredox catalytic process promoted by blue light. This approach provides practical and efficient access to chiral, ε‐ketobutenolides, in one step and high yields.
Guazzetti D, Aimi L, Marcantonio E, Siciliano GM, Bugatti K, Dobani S, Sartori A, Battistini L, Zanardi F, Curti C.   +9 more
europepmc   +2 more sources

Live-Cell RNA Imaging via Clickable TriPPPro Nucleotide Reporters. [PDF]

Angew Chem Int Ed Engl
The intracellular delivery of trans‐cyclooctene and bicyclo[6.1.0]nonyne as sterically demanding groups for the inverse electron‐demand Diels–Alder was achieved by the triphosphate prodrug (TriPPPro) strategy. Once hydrolyzed inside cells, the modified uridines and cytidines are metabolically incorporated into nascent RNA, are labelled by a dual ...
Knaack JIH, List E, Stalling D, Sterrenberg VT, Meier C, Wagenknecht HA, Bosse JB.   +6 more
europepmc   +2 more sources

Discovery of small molecule candidate therapeutics against neuroimmune targets in Alzheimer’s disease [PDF]

Alzheimers Dement
Abstract Background Dysregulated brain inflammation is a critical mechanism driving neurodegenerative disease progression. Neuroinflammatory processes are fundamental to CNS homeostasis, but inflammation that is inefficient, excessive, or prolonged is detrimental.
Eldik L, Roy S, Arancio O, Watterson D.
europepmc   +2 more sources

4,7-Di(9H-carbazol-9-yl)-[1,2,5]oxadiazolo[3,4-d]pyridazine

Molbank, 2022
Donor–acceptor–donor (D–A–D)-type molecules are considered as a promising class of NIR fluorescence materials. In this communication, 4,7-di(9H-carbazol-9-yl)-[1,2,5]oxadiazolo[3,4-d]pyridazine was obtained by dehydrogenation of 4,7-bis(1,2,3,4,4a,9a ...
Timofey N. Chmovzh, Timofey A. Kudryashev, Karim S. Gaisin, Oleg A. Rakitin   +3 more
doaj   +1 more source

Temperature dependent NIR emitting lanthanide-PMO/silica hybrid materials [PDF]

, 2017
Two materials - a mesoporous silica (MS) and a periodic mesoporous organosilica (PMO) functionalized with dipyridyl-pyridazine (dppz) units were grafted with near-infrared (NIR) emitting lanthanide (Nd3+, Er3+, Yb3+) complexes in an attempt to obtain ...
Esquivel, Dolores, Kaczmarek, Anna, Ouwehand, Judith, Romero-Salguero, Francisco J, Van Der Voort, Pascal, Van Deun, Rik   +5 more
core   +2 more sources

Pyridazines. IX. Proton Magnetic Resonance Studies of Pyridazine, Pyrazine, and Substituted Pyridazines.

Chemical and Pharmaceutical Bulletin, 1964
Pyridazine, pyrazine and substituted pyridazines have been studied by proton magnetic resonance spectroscopy. The spectra of pyridazine and pyrazine were analyzed completely with the aid of information obtained from the C13-satellites (in natural isotopic abundance), whereas the spectra of substituted pyridazines were analyzed easily by the usual ...
K, Tori, M, Ogata
openaire   +3 more sources

Tetrakis(pyridazine-κN)bis(selenocyanato-κN)cobalt(II) pyridazine disolvate

Acta Crystallographica Section E, 2012
Reaction of cobalt(II) nitrate with potassium selenocyanate and pyridazine leads to single crystals of the title compound, [Co(NCSe)2(C4H4N2)4]·2C4H4N2, which is isotypic with its nickel(II) thiocyanate analogue. The Co2+ cations are coordinated
Susanne Wöhlert, Mario Wriedt, Inke Jess, Christian Näther   +3 more
doaj   +1 more source

Theoretical study on the protonation of AZA-aromatics [PDF]

, 1975
The protonation of azanaphthalenes and azabenzenes has been studied theoretically using CNDO/2 wavefunctions and perturbation theory in order to examine the correlation between pKa values and quantum-mechanical ...
Meer, Douwe van der, Weijer, Peter van de   +1 more
core   +2 more sources

Tetrakis(pyridazine-κN)bis(selenocyanato-κN)nickel(II) pyridazine disolvate

Acta Crystallographica Section E, 2012
The reaction of nickel(II) nitrate with potassium selenocyanate and pyridazine leads to crystals of the title compound, [Ni(NCSe)2(C4H4N2)4]·2C4H4N2.
Susanne Wöhlert, Mario Wriedt, Inke Jess, Christian Näther   +3 more
doaj   +1 more source