Results 11 to 20 of about 3,099 (162)

Photoinduced, Chemoselective γ-Alkylation of 2-Silyloxyfurans With α-Bromoketones: A Rapid Entry to Chiral ε-Keto-γ-Butenolides. [PDF]

Chemistry
A photoinduced, regio‐ and chemoselective γ‐alkylation of 2‐silyloxyfurans with a‐bromoketones was achieved by exploiting a photoredox catalytic process promoted by blue light. This approach provides practical and efficient access to chiral, ε‐ketobutenolides, in one step and high yields.
Guazzetti D, Aimi L, Marcantonio E, Siciliano GM, Bugatti K, Dobani S, Sartori A, Battistini L, Zanardi F, Curti C.   +9 more
europepmc   +2 more sources

Live-Cell RNA Imaging via Clickable TriPPPro Nucleotide Reporters. [PDF]

Angew Chem Int Ed Engl
The intracellular delivery of trans‐cyclooctene and bicyclo[6.1.0]nonyne as sterically demanding groups for the inverse electron‐demand Diels–Alder was achieved by the triphosphate prodrug (TriPPPro) strategy. Once hydrolyzed inside cells, the modified uridines and cytidines are metabolically incorporated into nascent RNA, are labelled by a dual ...
Knaack JIH, List E, Stalling D, Sterrenberg VT, Meier C, Wagenknecht HA, Bosse JB.   +6 more
europepmc   +2 more sources

Tetrakis(pyridazine-κN)bis(selenocyanato-κN)nickel(II) pyridazine disolvate

Acta Crystallographica Section E, 2012
The reaction of nickel(II) nitrate with potassium selenocyanate and pyridazine leads to crystals of the title compound, [Ni(NCSe)2(C4H4N2)4]·2C4H4N2.
Susanne Wöhlert, Mario Wriedt, Inke Jess, Christian Näther   +3 more
doaj   +1 more source

Tetrakis(pyridazine-κN)bis(thiocyanato-κN)nickel(II) pyridazine disolvate

Acta Crystallographica Section E, 2012
The reaction of nickel(II) thiocyanate with an excess of pyridazine leads to single crystals of the title compound, [Ni(NCS)2(C4H4N2)4]·2C4H4N2.
Susanne Wöhlert, Mario Wriedt, Inke Jess, Christian Näther   +3 more
doaj   +1 more source

The Study of Pyridazine Compounds on Prostanoids: Inhibitors of COX, cAMP Phosphodiesterase, and TXA2 Synthase

Journal of Chemistry, 2014
The pyridazine moiety is an important structural feature of various pharmacological active compounds. Synthetic pyridazine compounds have been reported as effective antiprostaglandins (PGs), 5-lipoxygenase (5-LOX), and antiplatelet agents, that is ...
Mohammad Asif
doaj   +1 more source

Bis(methanol-1κO)tetra-μ-pyridazine-1:2κ4N:N′;2:3κ4N:N′-di-μ-thiocyanato-1:2κ2N:N;2:3κ2N:N-tetrathiocyanato-1κ2N,3κ2N-trinickel(II) methanol tetrasolvate

Acta Crystallographica Section E, 2012
Reaction of an excess nickel(II) thiocyanate with pyridazine leads to single crystals of the title compound, [Ni3(NCS)6(N2C4H4)4(CH3OH)2]·4CH3OH.
Susanne Wöhlert, Inke Jess, Christian Näther   +2 more
doaj   +1 more source

A brief review on Triazin-pyridazinones: Synthesis and biological activities

Mongolian Journal of Chemistry, 2017
A series of substituted triazin-pyridazine compounds were exhibited diverse types of biological activities and synthesized by different methods. These compounds were mainly tested for their anti-inflammatory, anticancer, antifungal and antibacterial ...
M Asif
doaj   +1 more source

Bis(dicyanamido-κN)tetrakis(pyridazine-κN)nickel(II)

Acta Crystallographica Section E, 2012
Reaction of nickel(II) chloride with sodium dicyanamide and pyridazine leads to single crystals of the title compound, [Ni{N(CN)2}2(C4H4N2)4], in which the NiII cation is octahedrally coordinated by two dicyanamide anions and four pyridazine ligands into
Christian Näther, Inke Jess, Mario Wriedt, Susanne Wöhlert   +3 more
doaj   +1 more source

Small‐Molecule Activation of mRNA Translation by Click‐to‐Release Reaction in Cells

Angewandte Chemie, EarlyView.
A new method to control mRNA activity using bioorthogonal click‐to‐release reactions is presented. The 5′ cap is modified with a trans‐cyclooctene (TCO) that quickly reacts with hydroxyaryl‐tetrazines and efficiently releases the native cap 0. TCO‐capped mRNAs are initially translationally inactive but can be activated with non‐toxic, cell‐permeable ...
Tess Vosman, Friedrich Burba, Martin Sumser, Milan Vrabel, Hannes Mikula, Andrea Rentmeister   +5 more
wiley   +2 more sources

Photocatalytic Cross‐Coupling of Phenols and Heteroaryl Halides With Machine Learning‐Guided Reaction Prediction

Angewandte Chemie, EarlyView.
Photocatalytic cross‐coupling: A redox‐neutral photochemical method enables direct C(sp2)─C(sp2) bond formation between phenols and heteroaryl halides using an organic dye and base. Complementary radical generation allows efficient cross‐coupling in up to 91% yield. Mechanistic studies, DFT, HTE, and machine learning rationalize and predict reactivity,
Matthew C. Carson, Alice Wu, Kalyana B. Duggal, Madeline E. Rotella, Marisa C. Kozlowski   +4 more
wiley   +2 more sources