Results 241 to 250 of about 1,014,531 (338)

FeIII‐Mediated Synthesis of Azaspirodienones via Ipso‐Radical Cyclization of Ugi–4CR Adducts

European Journal of Organic Chemistry, Volume 29, Issue 39, 22 October 2026.
An efficient two‐step protocol for the synthesis of azaspirodienones via Fe‐mediated ipso‐radical cyclization of Ugi adducts has been developed. This methodology provides rapid access to these privileged spirocyclic architectures under mild conditions, offering a practical and versatile approach to generating structurally complex molecules with ...
Silvia J. Becerra–Anaya, Valeria Morales–Hernández, Luis A. Polindara–García   +2 more
wiley   +1 more source

Scaffold hopping of furans into 3-cyanopyridines. [PDF]

Nat Commun
Kafle P, Yasuda S, Herndon D, Nilson D, Fox RC, Akhmedov NG, Sharma I.   +6 more
europepmc   +1 more source

Structure-Based Drug Discovery of Triazine Derivatives as Potent and Orally Bioavailable AXL Inhibitors for Cancer Therapy. [PDF]

ACS Omega
Sun M, Wu S, Zhong Y, Xi N, Cao Q.
europepmc   +1 more source

Photocatalysts for the decarboxylation conversion of C(sp³)-carboxylic acids: a review. [PDF]

RSC Adv
Gao C, Zhang J, Li G, Peng H.
europepmc   +1 more source

Multitarget Drug Design for Cardiovascular Disease: Bridging Chemistry and Medicine

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Many pathophysiological pathways associated with cardiovascular diseases involve multiple drug targets. This article reviews recent advances in the development of pharmacological compounds capable of simultaneously modulating multiple mechanisms. Multitarget drugs offer a promising therapeutic approach for complex cardiovascular disorders, including ...
Gyuzel Y. Mitronova, Vladimir N. Belov, Constanze Schmidt, Stephan E. Lehnart   +3 more
wiley   +1 more source

Engineering nonconventional yeasts to produce carboxylic acids: Advances and Prospects. [PDF]

Synth Syst Biotechnol
Zhang L, Fan Y, Shi W, Zhou X.
europepmc   +1 more source

Heteroleptic Iron(II) Spin-Crossover Complexes Based on a 2,6-Bis(pyrazol-1-yl)pyridine-type Ligand Functionalized with a Carboxylic Acid

, 2019
Víctor García‐López, Mario Palacios‐Corella, Verónica Gironés-Pérez, Carlos Bartual‐Murgui, José Antonio Real, E. Pellegrin, Javier Herrero‐Martín, Guillem Aromı́, Miguel Clemente‐León, Eugenio Coronado   +9 more
openalex   +2 more sources

Scaffold Hopping Provides Liver X Receptor Agonist With Preference for the β Subtype

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
A scaffold hopping strategy was pursued to enhance the binding pocket engagement and β‐subtype selectivity of liver X receptor agonist 2. The resulting spirocyclic lead compound, (S)‐7, demonstrates superior potency, enhanced potency‐based selectivity for LXRβ, and improved microsomal stability over the existing scaffold.
Annette Kärcher, Fiona L. Motel, Felix F. Lillich, Astrid Kaiser, Ewgenij Proschak, Pascal Heitel   +5 more
wiley   +1 more source

Synthesis of the Natural Product 1,3-Dibehenyl-2-ferulyl Glyceride (<i>Aquilaria malaccensis</i>) and Its Derivatives. [PDF]

Molecules
Sánchez-Esparza AJ, Cantú-Reyes M, Fragoso-Medina AJ, Nieto-Camacho A, Ortega-Ruiz MÁ, Osorio-Godínez OY, Chávez-Riveros A, Cuevas G, Contreras-Cruz DA.   +8 more
europepmc   +1 more source

Synthesis and characterization of pyridine-3-carboxylic acid hexamolybdochromate (С6H5NO2)2[H3O]4[CrMo6O18(OH)6].4Н2О

, 2019
Garry Z. Kaziev, Anna F. Stepnova, Van Bang Nguyen, Viktor N. Khrustalev, P.V. Dorovatovsky, S. H. Quenones, Universidad Autonoma Metropolitana (Azcapotzalco)   +6 more
openalex   +1 more source