Results 271 to 280 of about 1,014,531 (338)

De Novo Discovery of Nonstandard Thioisoindole‐Bridged Bicyclic Peptides Targeting Traf2‐ and NCK‐Interacting Kinase

Angewandte Chemie, Volume 138, Issue 41, 5 October 2026.
An optimized strategy for the ribosomal synthesis of thioisoindole‐bridged bicyclic (TiB) peptides is incorporated into the RaPID platform, enabling high‐throughput discovery from topologically defined TiB libraries. Proof‐of‐concept selection against TNIK identifies nanomolar‐affinity ligands with inhibitory activity, while x‐ray crystallography ...
Yue Zhang, Alexander A. Vinogradov, Keisuke Hamada, Yin Sun, Toru Sengoku, Hiroaki Suga   +5 more
wiley   +1 more source

Exploiting Multicomponent Reactions to Drive the Development of Novel Antitubercular Agents: An Overview. [PDF]

ChemMedChem
Nunes D, Moreira R, Perry MJ, Lopes F.
europepmc   +1 more source

Unnatural α-amino acid synthesis enabled by nickel-catalysed enantioselective hydrocarbamoylation of enamides via C‒H functionalisation. [PDF]

Nat Commun
Chen X, Kramer S.
europepmc   +1 more source

Discovery of Ligands for the TNFR1 Extracellular Domain Using Fragment-Based Drug Discovery. [PDF]

ChemMedChem
Chédotal H, Povlsen K, Narayanan D, Gotfredsen CH, Gajhede M, Bach A, Clausen MH.   +6 more
europepmc   +1 more source

Platinum Meets Pyridine: Affinity Studies of Pyridinecarboxylic Acids and Nicotinamide for Platinum-Based Drugs. [PDF]

Int J Mol Sci
Szefler B, Szupryczyński K, Czeleń P.
europepmc   +1 more source

A multi-tiered workflow for examining organic acid profiles delineates tissue-specific changes in fatty acyl partitioning during aging. [PDF]

Cell Rep Methods
Zhou Z, Cao C, Lu T, Ruan Y, Li B, Cao M, Mo L, Shui G, Lam SM.   +8 more
europepmc   +1 more source

X-ray Crystallography-Guided Design and Synthesis of Cyclopentyl Heteroaryl Carboxylic Acid-Based Inhibitors of the SARS-CoV-2 Nsp3 Macrodomain (Mac1). [PDF]

J Med Chem
Wang X, Butler WTW, Donald JR, Wang Y, Shaw AL, Schuller M, Fearon D, Aschenbrenner JC, Marples PG, Watt G, Lu Y, Lucas SCC, Bonomo S, Nelson JE, Ahel I, von Delft F, O'Brien P.   +16 more
europepmc   +1 more source

Investigation of non-covalent interactions and optical properties in a manganese (II) complex with pyridine- N-oxide -2- carboxylic acid

, 2019
H. A. Rahnamaye Aliabad, Mohammad Chahkandi   +1 more
openalex   +1 more source

Enzyme-catalysed synthesis of pyridines from biomass-derived feedstocks.

Org Biomol Chem
Sodré V, Rashid GMM, Yotzova BV, Bugg TDH.   +3 more
europepmc   +1 more source

Electrochemical oxidative amidation of alcohols towards <i>N</i>-acyl azoles as precursors for amides, esters and thioesters.

Org Biomol Chem
Bartels IMA, Witte MD, Minnaard AJ.
europepmc   +1 more source