Results 251 to 260 of about 1,014,531 (338)

Synthesis, Antiparasitic Activity, and ADME Profile of Morpholinephenylbenzamides: A Pharmacological Study Against Chagas Disease and Visceral Leishmaniasis

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Hit‐to‐lead optimization of morpholinephenylbenzamides reveals key structure–activity relationships against Trypanosoma cruzi and Leishmania infantum. Potency, selectivity, and ADME properties are differentially improved across the series, identifying compounds 20, 24, and 16 as complementary templates for the future design of dual antiparasitic leads.
Danilo Nascimento Farago, Daniela de Melo Resende, Mariza Gabriela Faleiro de Moura Lodi Cruz, Rafaela Marçal Sousa, Rafael Consolin Chelucci, Simone Michelan‐Duarte, Felipe da Silva Mendonça de Melo, Douglas Davison da Silva Oliveira, Paula Derksen Macruz, Alexandra Maria dos Santos Carvalho, Eduardo Jorge Pilau, Izabela Marques Dourado Bastos, Adriano D. Andricopulo, Leonardo L. G. Ferreira, Silvane Maria Fonseca Murta, Celso de Oliveira Rezende Júnior   +15 more
wiley   +1 more source

SESMic: A Reagent for the Synthesis of 5-Membered Heteroaryl Masked Sulfinates. [PDF]

Org Lett
Chi Y, Chan GH, Moschitto MJ.
europepmc   +1 more source

Discrepancy in Reported and Observed Monoacylglycerol Lipase Inhibition of Aryl Formyl Piperidine Containing Potent and Highly Selective Monoacylglycerol Lipase Inhibitor

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
A reported potent and selective reversible MAGL inhibitor fails to reproduce its claimed potency in two established in vitro assays, even when the previously reported substrate is used, while eight related analogs are likewise inactive. The findings highlight substantial assay‐dependent behavior and the need for careful validation before such compounds
Juha R. Savinainen, Praveen Kumar Singh, Jari Yli‐Kauhaluoma, Jayendra Z. Patel   +3 more
wiley   +1 more source

A unified strategy for remote C-H fluorination of phenylacetic acids and their homologues at the <i>meta</i>-position. [PDF]

Chem Sci
Zhou K, Chen X, Wang Y, Mao YJ, Yang X, Liu K, Pan Q, Pan DL, Xu DQ, Lou SJ.   +9 more
europepmc   +1 more source

The Natural Product Esculetin as an Efficient Photoacid for the Visible‐Light‐Mediated Acetalization/Ketalization Reaction

ChemSusChem, Volume 19, Issue 19, 14 October 2026.
Esculetin: an efficient photoacid catalyzing acetalization/ketalization reactions. The development of photochemical protocols for the production of fine chemicals and industrially interesting products, employing sustainable catalysts under mild conditions, is of high interest.
Maria A. Theodoropoulou, E. Alexandros Routsi, Christiana Mantzourani, Olga G. Mountanea, Demeter Tzeli, Christoforos G. Kokotos, George Kokotos   +6 more
wiley   +1 more source

Beyond traditional defunctionalized cross-coupling reaction: scope, limitations, practicability & future prospects of recent electrochemical methodologies. [PDF]

RSC Adv
Dhara S, Singh K, Shee J, Sahu PK, Barik P, Panda M, Mandal A, Ikbal M, Samanta S.   +8 more
europepmc   +1 more source

Encapsulation of Porphyrins in Polymer Microgels and Microbeads for Heterogeneous Photooxidation

ChemSusChem, Volume 19, Issue 19, 14 October 2026.
Amino‐ or ammonium‐functionalized tetraphenylporphyrins were synthesized and encapsulated within polymers to form microgels and microbeads that act as heterogeneous photocatalysts. Photooxidation in aqueous media quantitatively converts sulfides and aldehydes into sulfoxides and carboxylic acids via the singlet‐oxygen pathway, demonstrating an ...
Imogen Smith, Natthakarn Olanchantarothai, Martin R. Johnston, Zhongfan Jia   +3 more
wiley   +1 more source

Synthesis and Characterization of New Functionalized Pyrimidine (Hetero)Cyclic Molecular Hybrids as Chiral Heterocyclic Amino Acid Derivatives. [PDF]

Molecules
Voznikaitė P, Račkauskienė G, Dagilienė M, Kederienė V, Sløk FA, Šačkus A.   +5 more
europepmc   +1 more source

SYNTHESIS CHARACTERISATION AND ANTIBACTERIAL ACTIVITY STUDIES OF PICOLIOHYDRAZIDE(2-PYRIDINE CARBOXYLIC ACID HYDRAZIDE)

, 2020
Senthilkumaran J
openalex   +1 more source