Results 71 to 80 of about 1,014,531 (338)

Injectable Peptide‐Based Functional Amyloid Hydrogels as Tunable Depots for Sustained Drug Delivery

Advanced Science, EarlyView.
An injectable and tunable peptide‐based functional amyloid hydrogel provides sustained insulin release while preserving insulin stability and bioactivity. The hydrogel enables prolonged glycemic regulation in vivo, exhibits excellent biocompatibility, and shows no detectable IAPP and α‐Syn heterologous cross‐seeding, highlighting its potential as a ...
Ranjit Shaw, Niyamat M. A. Chimthanawala, Shouvik Manna, Sadhana Sathaye, Samir K. Maji   +4 more
wiley   +1 more source

Condensation of Carboxylic Acids with Non-Nucleophilic N‑Heterocycles and Anilides Using Boc₂O

, 2016
A novel condensation reaction of carboxylic acids with various non-nucleophilic N-heterocycles and anilides was developed. The reaction proceeds in the presence of di-tert-butyl dicarbonate (Boc2O), catalytic 4-(dimethylamino)­pyridine (DMAP), and 2,6 ...
Hirofumi Ueda (1748680), Hidetoshi Tokuyama (1748674), Atsushi Umehara (1814875)   +2 more
core   +1 more source

Dichloridobis(3-{[(pyridin-2-yl)methylidene]amino}benzoic acid-κ2N,N′)cobalt(II) methanol monosolvate monohydrate

IUCrData
The orthorhombic (space group Pna21) unit cell of the title compound, [CoCl2(C13H10N2O2)2]·CH3OH·H2O, contains eight complex molecules, four A and four B, along with sixteen solvent molecules of crystallization.
Olga Yu. Vassilyeva, Vladimir N. Kokozay, Brian W. Skelton   +2 more
doaj   +1 more source

Ligand-enabled ruthenium-catalyzed meta-C−H alkylation of (hetero)aromatic carboxylic acids

Nature Communications
Carboxylates are ideal directing groups because they are widely available, readily cleavable and excellent linchpins for diverse follow-up reactions.
Xianglin Luo, Peichao Hou, Jiayi Shen, Yifeng Kuang, Fengchao Sun, Huanfeng Jiang, Lukas J. Gooßen, Liangbin Huang   +7 more
doaj   +1 more source

Supramolecular synthon hierarchy in sulfonamide cocrystals with syn-amides and N-oxides

IUCrJ, 2019
Sulfonamide drugs are well known antibacterial and antimicrobial molecules for pharmaceutical development. Building a library of suitable supramolecular synthons for the sulfonamide functional group and understanding their crystal structures with partner
Geetha Bolla, Ashwini Nangia
doaj   +1 more source

Doebner-type pyrazolopyridine carboxylic acids in an Ugi four-component reaction

Beilstein Journal of Organic Chemistry, 2019
Substituted 1H-pyrazolo[3,4-b]pyridine-4- and 1H-pyrazolo[3,4-b]pyridine-6-carboxamides have been synthetized through a Doebner–Ugi multicomponent reaction sequence in a convergent and versatile manner using diversity generation strategies: combination ...
Maryna V. Murlykina, Oleksandr V. Kolomiets, Maryna M. Kornet, Yana I. Sakhno, Sergey M. Desenko, Victoriya V. Dyakonenko, Svetlana V. Shishkina, Oleksandr A. Brazhko, Vladimir I. Musatov, Alexander V. Tsygankov, Erik V. Van der Eycken, Valentyn A. Chebanov   +11 more
doaj   +1 more source

Salts and Co-Crystalline Assemblies of Tetra(4-Pyridyl)Ethylene with Di-Carboxylic Acids

Crystals, 2018
Tetraarylethylene derivatives are emerging as an increasingly important family of supramolecular building blocks in both solution phase and the solid state. The utility of tetraarylethylenes stems from appealing structural features (rigidity and symmetry)
Moustafa T. Gabr, F. Christopher Pigge
doaj   +1 more source

Influence of pyridyl nitrogen’s position and hydrogen bonding interactions on antibacterial activities investigated by in vitro and in silico

Scientific Reports
Pyridine derivatives are multifunctional materials with various biological activities viz., antibacterial, antiviral, anticancer, antihistamine, etc. and are also the building blocks in supramolecular chemistry.
Suma Ramachandra Gopady, Thripthi Nagesh Shenoy, Abdul Ajees Abdul Salam, Srikrishna Herga Damodar Kedlaya, Shashanka Puranika Kota, Anusha Prabhu, Yegneswaran Prakash Peralam, Srinivasulu Maddasani   +7 more
doaj   +1 more source

Hydrogen-bond induced surface core-level shift in pyridine carboxylic acids

, 2001
Intermolecular hydrogen bonding in thick films of pyridine carboxylic acids (isonicotinic; picolinic and bi-isonicotinic acid) evaporated onto rutile TiO2(1 1 0) has been investigated with X-ray photoelectron spectroscopy and X-ray absorption ...
Schnadt, J, Hillesheimer, H, Patthey, L, Bruhwiler, PA, Nordlund, D, Luo, Yi, Nagasono, M, Krempasky, J, Martensson, N, O'Shea, JN,   +9 more
core  

Synthesis of amides from carboxylic acids and urea in the presence of pyridine under microwave irradiation

, 2005
A very simple and efficient procedure for the synthesis of primary amides from carboxylic acids and urea in presence of pyridine under microwave irradiation is described.
Pasha, M.A., Jayashankara, V.P.
core