Results 121 to 130 of about 36,481 (241)
Integrating Kinetics into Synthetic Studies via Adaptable Concentration‐Dependent Yield Analysis
Advanced Science, EarlyView.A method to derive kinetic parameters from synthetic studies was developed and named concentration‐dependent yield analysis (CYAN). Using numerical Euler integration for kinetic regression, CYAN was proven adaptable to chemical and operational considerations and revealed unexpected template effects of a transition metal that mediated competitive ...
Xinyi Xiao +4 more
wiley +1 more source
Advanced Science, EarlyView.A glutathione and ultrasound dual‐responsive cerasome achieves sequential co‐delivery of gemcitabine and BMS1166 in tumors. Chemotherapy priming followed by on‐demand PD‐L1 blockade synergistically amplifies anti‐tumor immunity, inhibiting primary tumor growth, distant metastasis and inducing durable immune memory.
Suhui Sun +9 more
wiley +1 more source
, 2019 An efficient copper-catalyzed cascade alkynylation/cyclization/isomerization reaction of aurone-derived azadienes with terminal alkynes has been developed, giving a series of 1,2-dihydrobenzofuro[3,2-b]pyridines with excellent yields.
Bo Wu (16141) +3 more
core +2 more sources
Advanced Science, EarlyView.Permanent oxidative dipole (POD) engineering overcomes the electronic uniformity of quinoline‐linked COFs. By enhancing the dipole moment to 2.08 D and lowering exciton binding energy to 20.3 meV, it constructs a robust built‐in electric field and spatially decoupled redox centers. This bypasses inherent kinetic bottlenecks, achieving a 4569 µmol g−1 h−
Yong‐Quan Wu +2 more
wiley +1 more source
Oxidative Dearomatization of Pyridines
Dearomatization of pyridines is a well-established synthetic approach to access piperidines. Although remarkably powerful, existing dearomatization processes have been limited to the hydrogenation or addition of carbon-based nucleophiles to activated ...
David Sarlah (1617298) +5 more
core +1 more source
Preparation of didehydropyridines from (trimethylsilyl)pyridines
, 2010 Halogen-substituted (trimethylsilyl)pyridines 2, 3, 5 - 7 and trifluoromethylsulfonyloxy-substituted (trimethylsilyl)pyridines 9b, 11b are obtained from 2- and 3-halopyridines 1, 4 or hydroxypyridines 8, 10, and 12.
Effenberger, Franz, Daub, Wolfgang
core +1 more source
Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications
Advanced Science, EarlyView.Smart bioinks empower 4D‐bioprinted constructs to dynamically adapt and remodel in response to stimuli, effectively biomimicking native tissues. Artificial Intelligence (AI) and Machine Learning (ML) play a guiding role in their rational design by optimizing relevant properties.
Shangsi Chen +11 more
wiley +1 more source
Advanced Science, EarlyView.In this review, the classification and development history of the volatile solid and solvent additives are comprehensively summarized, the underlying mechanisms of morphology optimization are discussed, and a summary of volatile additive‐induced improvements in interfacial layer performance is provided.
Jianqiang Qin +7 more
wiley +1 more source
Functionalization of Pyridines at Remote Synthetic Landscapes via Undirected Metalation and Capture [PDF]
The undirected functionalization of pyridines at positions remote to the N-atom remains an outstanding problem in organic synthesis. The inherent challenges associated with overriding the strong directing influence of the embedded N-atom within pyridine ...
Seokmin, Kang +4 more
core +2 more sources
cis‐Carboxylate Enhancement of Mn(III)‐OH Hydrogen Atom Abstraction through PCET Thermodynamics
Advanced Science, EarlyView.ABSTRACT Manganese(III)‐hydroxo intermediates are proposed as key hydrogen atom abstraction (HAA) species in manganese‐dependent enzymes, yet how first‐sphere carboxylate ligands control their proton‐coupled electron transfer (PCET) thermodynamics remains poorly understood.
Yuri Lee +4 more
wiley +1 more source