Results 281 to 290 of about 212,860 (340)

Radical and ionic meta-C–H functionalization of pyridines, quinolines, and isoquinolines

Science, 2022
Carbon-hydrogen (C−H) functionalization of pyridines is a powerful tool for the rapid construction and derivatization of many agrochemicals, pharmaceuticals, and materials.
Hui Cao, Q. Cheng, A. Studer
semanticscholar   +1 more source

Borane-Catalyzed C3-Alkylation of Pyridines with Imines, Aldehydes, or Ketones as Electrophiles.

Journal of the American Chemical Society, 2022
Achieving C3-selective pyridine functionalization is a longstanding challenge in organic chemistry. The existing methods, including electrophilic aromatic substitution and C-H activation, often require harsh reaction conditions and excess pyridine and ...
Zhong Liu, Jiayao He, Ming Zhang, Zhuangzhuang Shi, Hang-Jun Tang, Xin-Yue Zhou, Jun Tian, Xiao‐Chen Wang   +7 more
semanticscholar   +1 more source

C3-Selective Trifluoromethylthiolation and Difluoromethylthiolation of Pyridines and Pyridine Drugs via Dihydropyridine Intermediates.

Journal of the American Chemical Society, 2022
Herein, we report a method for unprecedented C3-selective C-H tri- and difluoromethylthiolation of pyridines. The method relies on borane-catalyzed pyridine hydroboration for generation of nucleophilic dihydropyridines; these intermediates react with ...
Xin-Yue Zhou, Ming Zhang, Zhong Liu, Jiayao He, Xiao‐Chen Wang   +4 more
semanticscholar   +1 more source

Enantioselective C2-H Alkylation of Pyridines with 1,3-Dienes via Ni-Al Bimetallic Catalysis.

Journal of the American Chemical Society, 2022
A chiral phosphine oxide-ligated Ni-Al bimetallic catalyst was used to realize an enantioselective C2-H alkylation of pyridines without the need of a C2-block.
Jiangting Li, Deng Pan, Hao Wang, Tao Zhang, Yi Li, Genping Huang, Mengchun Ye   +6 more
semanticscholar   +1 more source

C3-Cyanation of Pyridines: Constraints on Electrophiles and Determinants of Regioselectivity.

Angewandte Chemie, 2022
Methods for C-H cyanation of pyridines are rare. Here, we report a method for C3-selective cyanation of pyridines by a tandem process with the reaction of an in situ generated dihydropyridine with a cyano electrophile as the key step.
Ming Zhang, Qingyang Zhou, Heng Luo, Zi-Lu Tang, Xiufang Xu, Xiao‐Chen Wang   +5 more
semanticscholar   +1 more source

Visible-Light-Enabled Trifluoromethylative Pyridylation of Alkenes from Pyridines and Triflic Anhydride.

Angewandte Chemie, 2020
A general strategy for visible-light-enabled site-selective trifluoromethylative pyridylation of unactivated alkenes has been developed using pyridines and triflic anhydride (Tf 2 O).
Kangjae Lee, Seojin Lee, Namhoon Kim, Seonyul Kim, Sungwoo Hong   +4 more
semanticscholar   +1 more source

Recent Developments in Transition-Metal-Free Functionalization and Derivatization Reactions of Pyridines

Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry, 2020
Pyridine is an important structural motif that is prevalent in natural products, drugs, and materials. Methods that functionalize and derivatize pyridines have gained significant attention. Recently, a large number of transition-metal-free reactions have
Fei Zhou, Lei Jiao
semanticscholar   +1 more source

Regio- and Enantioselective C-H Cyclization of Pyridines with Alkenes Enabled by a Nickel/N-Heterocyclic Carbene Catalysis.

Journal of the American Chemical Society, 2019
Annulated pyridines are ubiquitous scaffolds in many bioactive molecules. A highly regio- and enantioselective Ni(0)-catalyzed endo-selective C-H cyclization of pyridines with alkenes has been developed.
Wu-Bin Zhang, Xin-Tuo Yang, Junning Ma, Z. Su, Shi‐Liang Shi   +4 more
semanticscholar   +1 more source

SESQUITERPENE PYRIDINE ALKALOIDS

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
openaire   +2 more sources

Redox-Divergent Synthesis of Fluoroalkylated Pyridines and 2-Pyridones through Cu-Catalyzed N-O Cleavage of Oxime Acetates.

Angewandte Chemie, 2018
Cu-catalyzed redox-divergent [3+3] coupling of oxime esters with β-CF3 enones and acrylates is described. This redox-neutral coupling with enones and acrylates affords trifluoromethylated pyridines and pyridones, respectively. Under reductive conditions,
Dachang Bai, Xueli Wang, G. Zheng, Xingwei Li   +3 more
semanticscholar   +1 more source