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Antimycobacterial Activity of Quaternary Pyridinium Salts and Pyridinium N-oxides - Review
Current Pharmaceutical Design, 2012The treatment of tuberculosis and other mycobacterioses is still a major world health problem and new antimycobacterial compounds unrelated to approved drugs are in demand. Quaternary ammonium salts have revealed many usable properties especially as antimicrobials; they are widely used as disinfection and antiseptic agents.
Martin, Krátký, Jarmila, Vinšová
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Hexahydrobenzothiazolo[3,2-a]pyridinium salts
Chemistry of Heterocyclic Compounds, 1988Salts of hexahydrobenzothiazolo[3,2-a]pyridine are obtained by exchange reactions. Anions are placed in the order [(NC)2CCHC(CN)2]- > ClO4−>I3−>Br− according to the ability to displace each other. X-ray structural and spectroscopic studies establish the cis-attachment of the thiazolidine and cyclohexane rings in the hexahydrobenzothiazolo [3,2-a ...
A. M. Shestopalov +6 more
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Recyclization of polysubstituted pyridinium salts
Tetrahedron, 1995Abstract 3,5-Diacetyl- and 3,5-dicyano-1,2,6-trimethylpvridinium perchlorates are converted by recyclization into N,5-dimethylanilines and 2-methylaminopyridines, respectively.
Galina P. Shkil +3 more
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Dimerization of pyridinium salts by cyanide
Journal of the Chemical Society D: Chemical Communications, 19701,1′-Dihydro-4,4′-bipyridyls (II) are formed from certain pyridinium or 2-methylpyridinium salts and sodium cyanide.
Lawrence J. Winters +2 more
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N-(?-ferrocenylalkyl) pyridinium salts
Bulletin of the Academy of Sciences, USSR Division of Chemical Science, 19661. N- (α-Ferrocenylalkyl)pyridinium p-toluenesulfonates are formed when ferrocenylcarbinols are reacted with p-toluenesulfonyl chloride in pyridine. 2. The N-(α-ferrocenylalkyl)pyridinium salts are good ferrocenylalkylating agents.
A. N. Nesmeyanov +2 more
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Imidazo [1,2‐a] pyridinium salts
Journal of Heterocyclic Chemistry, 1965Abstract2‐Alkylamino‐ or arylaminopyridines react directly with α‐bromoketones to afford 1‐alkyl‐ or 1‐arylimidazo[1,2‐a]pyridinium salts with substituents at position 2. Use of chloroacetaldoxime as the quaternizing agent yields (after hydrolysis) the imidazo‐[1,2‐a]pyridinium ion with no substituent at position 2.
C. K. Bradsher +2 more
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Pyridinium Salts as Organophosphate Antagonists
2015By a standard screening in vivo, a series of pyridinium salts were tested for their protective activity against organophosphate poisoning. In order to obtain information about the protective mechanisms, several biochemical properties of these compounds were investigated in vitro, viz., their influence upon the enzymes cholineacetyltransferase and ...
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Thiazolo [3,2‐a] pyridinium salts
Journal of Heterocyclic Chemistry, 1966AbstractThe sulfides formed by the reaction of α‐halo ketones or α‐halo acetals with 2‐mercaptopyridine may be cyclized in good yield to form thiazolo[3, 2‐a]pyridinium salts. The presence of chloro or nitro substituents on the pyridine ring does not interfere with the synthesis.
C. K. Bradsher, D. F. Lohr
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The reaction of N-nitrosamines with pyridinium salts
Talanta, 1988N-Nitrosamines react readily with pyridinium salts containing an activated methylene group to give hydrazones. This reaction may serve as the basis for the routine determination of N-nitrosamines.
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Catalytic hydrogenation of pyridinium salts
Chemistry of Heterocyclic Compounds, 1994Catalytic hydrogenation of polysubstituted pyridinium salts leads to piperidines and their condensed analogs The spatial properties and conformational properties of the saturated azaheterocycles have been determined by13C NMR spectorscopy. It was shown that hydrogenation of the pyridinium salts occurs stereoselectively to form cis isomers in most cases.
P. V. Reshetov +2 more
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