Results 1 to 10 of about 22,936 (245)

Crystal structures of human pyridoxal kinase in complex with the neurotoxins, ginkgotoxin and theophylline: insights into pyridoxal kinase inhibition. [PDF]

PLoS ONE, 2012
Several drugs and natural compounds are known to be highly neurotoxic, triggering epileptic convulsions or seizures, and causing headaches, agitations, as well as other neuronal symptoms.
Amit K Gandhi, Jigar V Desai, Mohini S Ghatge, Martino L di Salvo, Stefano Di Biase, Richmond Danso-Danquah, Faik N Musayev, Roberto Contestabile, Verne Schirch, Martin K Safo   +9 more
doaj   +10 more sources

Pyridoxal 5'-phosphate is a slow tight binding inhibitor of E. coli pyridoxal kinase. [PDF]

PLoS ONE, 2012
Pyridoxal 5'-phosphate (PLP) is a cofactor for dozens of B(6) requiring enzymes. PLP reacts with apo-B(6) enzymes by forming an aldimine linkage with the ε-amino group of an active site lysine residue, thus yielding the catalytically active holo-B(6 ...
Mohini S Ghatge, Roberto Contestabile, Martino L di Salvo, Jigar V Desai, Amit K Gandhi, Christina M Camara, Rita Florio, Isabel N González, Alessia Parroni, Verne Schirch, Martin K Safo   +10 more
doaj   +9 more sources

Natural product P57 induces hypothermia through targeting pyridoxal kinase [PDF]

Nature Communications, 2023
Induction of hypothermia during hibernation/torpor enables certain mammals to survive under extreme environmental conditions. However, pharmacological induction of hypothermia in most mammals remains a huge challenge.
Ruina Wang, Lei Xiao, Jianbo Pan, Guangsen Bao, Yunmei Zhu, Di Zhu, Jun Wang, Chengfeng Pei, Qinfeng Ma, Xian Fu, Ziruoyu Wang, Mengdi Zhu, Guoxiang Wang, Ling Gong, Qiuping Tong, Min Jiang, Junchi Hu, Miao He, Yun Wang, Tiejun Li, Chunmin Liang, Wei Li, Chunmei Xia, Zengxia Li, Dengke K. Ma, Minjia Tan, Jun Yan Liu, Wei Jiang, Cheng Luo, Biao Yu, Yongjun Dang   +30 more
doaj   +6 more sources

The expression of four pyridoxal kinase (PDXK) human variants in Drosophila impacts on genome integrity [PDF]

Scientific Reports, 2019
In eukaryotes, pyridoxal kinase (PDXK) acts in vitamin B6 salvage pathway to produce pyridoxal 5′-phosphate (PLP), the active form of the vitamin, which is implicated in numerous crucial metabolic reactions.
Elisa Mascolo, Anna Barile, Lorenzo Stufera Mecarelli, Noemi Amoroso, Chiara Merigliano, Arianna Massimi, Isabella Saggio, Torben Hansen, Angela Tramonti, Martino Luigi Di Salvo, Fabrizio Barbetti, Roberto Contestabile, Fiammetta Vernì   +12 more
doaj   +4 more sources

Inhibiting Pyridoxal Kinase of Entamoeba histolytica Is Lethal for This Pathogen [PDF]

Frontiers in Cellular and Infection Microbiology, 2021
Pyridoxal 5’-phosphate (PLP) functions as a cofactor for hundreds of different enzymes that are crucial to the survival of microorganisms. PLP-dependent enzymes have been extensively characterized and proposed as drug targets in Entamoeba histolytica ...
Suneeta Devi, Priya Tomar, Khaja Faisal Tarique, Khaja Faisal Tarique, Samudrala Gourinath   +4 more
doaj   +2 more sources

Pyridoxal kinase and poly(ADP-ribose) affect the immune microenvironment of locally advanced cancers [PDF]

OncoImmunology, 2021
Malignant cells adapt to the hostile tumor microenvironment by escaping from, or actively suppressing, anticancer immune responses. In the past, we reported that reduced synthesis of active vitamin B6 (due to downregulation of pyridoxal kinase) or ...
Adrien Joseph, Juncheng Pan, Judith Michels, Guido Kroemer, Maria Castedo   +4 more
doaj   +2 more sources

Recombinant expression, purification and characterization of Bombyx mori (Lepidoptera: Bombycidae) pyridoxal kinase [PDF]

European Journal of Entomology, 2011
Pyridoxal kinase (PLK; EC 2.7.1.35) is a key enzyme in the metabolism of vitamin B6 (VB6) in Bombyx mori. A fusion expressional vector pET-22b-BPLK-His was constructed using a sub-cloning technique, the recombinant B.
Shuo-Hao HUANG, Wang MA, Ping-Ping ZHANG, Jian-Yun ZHANG, Yan-Feng XIE, Long-Quan HUANG   +5 more
doaj   +2 more sources

Roscovitine Targets, Protein Kinases and Pyridoxal Kinase [PDF]

Journal of Biological Chemistry, 2005
(R)-Roscovitine (CYC202) is often referred to as a "selective inhibitor of cyclin-dependent kinases." Besides its use as a biological tool in cell cycle, neuronal functions, and apoptosis studies, it is currently evaluated as a potential drug to treat cancers, neurodegenerative diseases, viral infections, and glomerulonephritis.
Stéphane Bach, Marie Knockaert, Jens Reinhardt, Olivier Lozach, Sophie Schmitt, Blandine Baratte, Marcel Koken, Stephen P. Coburn, Lin Tang, Tao Jiang, Dongcai Liang, Hervé Galons, Jean‐François Dierick, Lorenzo A. Pinna, Flavio Meggio, Frank Totzke, Christoph Schächtele, Andrea S. Lerman, Amancio Carnero, Yongqin Wan, Nathanael S. Gray, Laurent Meijer   +21 more
openalex   +7 more sources

VALUATION OF THE ANTI-LEISHMANIAL POTENTIAL OF SOME PROMINENT LEAD COMPOUNDS AGAINST PYRIDOXAL KINASE IN COMPLEX WITH ADENOSINE DIPHOSPHATE AND PYRIDOXINE: A COMPARATIVE STUDY [PDF]

Acta Scientifica Malaysia
More than twelve million individuals globally suffer from leishmaniasis, and an additional billion people are at risk in leishmaniasis prevalent areas. This work was motivated by the need to create drugs with high efficacies against leishmaniasis and to ...
Fabian Audu Ugbe, Abdullahi Muhammad Ayuba, Emmanuel Israel Edache, Anne Jibrin, Oluwagbemiga Tayo Amusan   +4 more
doaj   +2 more sources

Pyridoxal kinase inhibition by artemisinins down-regulates inhibitory neurotransmission. [PDF]

Proc Natl Acad Sci U S A, 2020
ABSTRACTThe anti-malarial artemisinins have also been implicated in the regulation of various other cellular pathways. Despite their widespread application, the cellular specificities and molecular mechanisms of target recognition by artemisinins remain poorly characterized.
Kasaragod VB, Pacios-Michelena A, Schaefer N, Zheng F, Bader N, Alzheimer C, Villmann C, Schindelin H.   +7 more
europepmc   +4 more sources