Results 21 to 30 of about 888,200 (233)
European Journal of Biochemistry, 1986 Pyridoxal kinase has been purified 9000‐fold from sheep brain. The purification procedure involves ammonium sulphate fractionation, DEAE‐cellulose chromatography, affinity chromatography and Sephadex G‐100 gel filtration. The final chromatography step yields a homogeneous preparation of high specific activity with a pI of 5.
J A, Kerry, M, Rohde, F, Kwok
openaire +2 more sources
Roscovitine Targets, Protein Kinases and Pyridoxal Kinase [PDF]
Journal of Biological Chemistry, 2005 (R)-Roscovitine (CYC202) is often referred to as a "selective inhibitor of cyclin-dependent kinases." Besides its use as a biological tool in cell cycle, neuronal functions, and apoptosis studies, it is currently evaluated as a potential drug to treat cancers, neurodegenerative diseases, viral infections, and glomerulonephritis.
Bach, S. +21 more
openaire +5 more sources
Applied Biological Chemistry, 2022 Background Circular RNA pyridoxal kinase (circPDXK; hsa_circ_0061893) is newly identified to be aberrantly expressed in ovarian cancer (OVCA); however, its functional role in OVCA cells remains to be expounded.
Lijuan Hou +3 more
semanticscholar +1 more source
Multiple mutations in heterogeneous miltefosine-resistant Leishmania major population as determined by whole genome sequencing. [PDF]
PLoS Neglected Tropical Diseases, 2012 Miltefosine (MF) is the first oral compound used in the chemotherapy against leishmaniasis. Since the mechanism of action of this drug and the targets of MF in Leishmania are unclear, we generated in a step-by-step manner Leishmania major promastigote ...
Adriano C Coelho +5 more
doaj +1 more source
The intestine plays a substantial role in human vitamin B6 metabolism: a Caco-2 cell model. [PDF]
PLoS ONE, 2013 BACKGROUND: Vitamin B6 is present in various forms (vitamers) in the diet that need to be metabolized to pyridoxal phosphate (PLP), the active cofactor form of vitamin B6.
Monique Albersen +8 more
doaj +1 more source
Pharmaceutics, 2023 Tumor metastasis is a major concern in cancer therapy. In this context, focal adhesion kinase (FAK) gene overexpression, which mediates cancer cell migration and invasion, has been reported in several human tumors and is considered a potential ...
Tilahun Ayane Debele +3 more
doaj +1 more source
Protective role of vitamin B6 (PLP) against DNA damage in Drosophila models of type 2 diabetes [PDF]
, 2018 Growing evidence shows that improper intake of vitamin B6 increases cancer risk and several studies indicate that diabetic patients have a higher risk of developing tumors.
MF Fenech +69 more
core +2 more sources
A screen for suppressors of gross chromosomal rearrangements identifies a conserved role for PLP in preventing DNA lesions. [PDF]
PLoS Genetics, 2007 Genome instability is a hallmark of cancer cells. One class of genome aberrations prevalent in tumor cells is termed gross chromosomal rearrangements (GCRs).
Pamela Kanellis +9 more
doaj +1 more source
Toward eradication of B-vitamin deficiencies : considerations for crop biofortification [PDF]
, 2018 'Hidden hunger' involves insufficient intake of micronutrients and is estimated to affect over two billion people on a global scale. Malnutrition of vitamins and minerals is known to cause an alarming number of casualties, even in the developed world ...
Strobbe, Simon +1 more
core +3 more sources
Poisoning pyridoxal 5-phosphate-dependent enzymes: a new strategy to target the malaria parasite Plasmodium falciparum. [PDF]
PLoS ONE, 2009 The human malaria parasite Plasmodium falciparum is able to synthesize de novo pyridoxal 5-phosphate (PLP), a crucial cofactor, during erythrocytic schizogony.
Ingrid B Müller +6 more
doaj +1 more source