Results 21 to 30 of about 69 (69)

Pyridoxal 5′-Phosphate Is a Slow Tight Binding Inhibitor of E. coli Pyridoxal Kinase

PLoS ONE, 2012
Pyridoxal 5'-phosphate (PLP) is a cofactor for dozens of B(6) requiring enzymes. PLP reacts with apo-B(6) enzymes by forming an aldimine linkage with the ε-amino group of an active site lysine residue, thus yielding the catalytically active holo-B(6) enzyme.
Isabel N. González, Verne Schirch, Amit Gandhi, Roberto Contestabile, Alessia Parroni, Martin K. Safo, Jigar V. Desai, Martino L. di Salvo, Rita Florio, Christina M. Camara, Mohini S. Ghatge   +10 more
openaire   +7 more sources

Protometabolic functions of pyridoxal: A link between early amino acid synthesis and enzyme evolution

The FEBS Journal, EarlyView.
Schlikker et al. characterized the conversion of pyridoxal to pyridoxamine under conditions mimicking the ones likely existing at the origin of metabolism. These conditions triggered nitrogen incorporation into amino acids in solution before the origins of enzymes.
Mariarita Bertoldi, Gianluca Molla
wiley   +1 more source

Regorafenib‐Induced Hand‐Foot Skin Reaction in an Adolescent

Pediatric Dermatology, EarlyView.
ABSTRACT Regorafenib is a multikinase inhibitor commonly used in the management of hepatocellular carcinoma, gastrointestinal stromal tumors (GIST), and colorectal cancer. It is also used off‐label for progressive or metastatic osteosarcoma, which is the most common primary bone malignancy in children and adolescents.
Kiera Murphy, Bansri Patel, Shantelle Griffith, Thomas N. Helm   +3 more
wiley   +1 more source

The Essentiality of Amino Acids in Healthiness and Disease State: Type II Diabetes as a Case Study

Food Science &Nutrition, Volume 13, Issue 6, June 2025.
This review investigates the functions of amino acids in normal physiological states, their potential as a diagnostic biomarker, the probable risk of deficiency, and the therapeutic ability for managing and preventing type 2 diabetes mellitus. ABSTRACT A healthy life depends on the availability and the synthesis of amino acids as they are building ...
Samuel Idowu Fayomi, Ochuko Lucky Erukainure, Nontokozo Zimbili Msomi   +2 more
wiley   +1 more source

Human Pyridoxal Kinase [PDF]

Journal of Biological Chemistry, 1997
Peptide fragments of a porcine benzodiazepine-binding protein were used to isolate the cDNA of a related human protein. The cDNA encodes a polypeptide of 312 amino acid residues that is homologous to a bacterial pyridoxal kinase. Transient expression of the cDNA in human embryonic kidney cells confirmed that it encodes human pyridoxal kinase.
Anthony J. Turner, Ewen F. Kirkness, Michael C. Hanna   +2 more
openaire   +3 more sources

Neural Metabolic Networks: Key Elements of Healthy Brain Function

Journal of Neurochemistry, Volume 169, Issue 6, June 2025.
This review originated from the Fourth International Society for Neurochemistry (ISN) and Journal of Neurochemistry (JNC) Flagship School (2022). Here, we describe how the specific bioenergetic profiles and metabolic exchanges between brain cells enable and gate synaptic function and behavior. Then, based on this analysis, we discuss the potential role
Nimrod Madrer, Nirma D. Perera, Nonthué A. Uccelli, Alice Abbondanza, Jens V. Andersen, Emma Veronica Carsana, Matthew D. Demmings, Regina F. Fernandez, Matheus Garcia de Fragas, Ismail Gbadamosi, Divita Kulshrestha, Ricardo A. S. Lima‐Filho, Oana C. Marian, Kia H. Markussen, Andrew J. McGovern, Elliott S. Neal, Sukanya Sarkar, Eva Šimončičová, Jazmín Soto‐Verdugo, Sozerko Yandiev, Ignacio Fernández‐Moncada   +20 more
wiley   +1 more source

Characterization of Two Kinases Involved in Thiamine Pyrophosphate and Pyridoxal Phosphate Biosynthesis in Bacillus subtilis : 4-Amino-5-Hydroxymethyl-2-Methylpyrimidine Kinase and Pyridoxal Kinase [PDF]

Journal of Bacteriology, 2004
ABSTRACT Two Bacillus subtilis genes encoding two proteins (currently annotated ThiD and YjbV) were overexpressed and characterized. YjbV has 4-amino-5-hydroxymethyl-2-methylpyrimidine and 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate kinase activity and should be reannotated ThiD, and
Joo-Heon Park, Cynthia Kinsland, Kristin E. Burns, Tadhg P. Begley   +3 more
openaire   +3 more sources

Plant genetic transformation: achievements, current status and future prospects

Plant Biotechnology Journal, Volume 23, Issue 6, Page 2034-2058, June 2025.
Summary Regeneration represents a fundamental biological process wherein an organism's tissues or organs repair and replace themselves following damage or environmental stress. In plant systems, injured tree branches can regenerate adventitious buds and develop new crowns through propagation techniques like cuttings and canopy pruning, while transgenic
Peilin Wang, Huan Si, Chenhui Li, Zhongping Xu, Huiming Guo, Shuangxia Jin, Hongmei Cheng   +6 more
wiley   +1 more source

Mother knows worst? Fungal infection enhances corn flavonoid of wogonin to inhibit Conogethes punctiferalis larval growth

Plant Biotechnology Journal, Volume 23, Issue 6, Page 2254-2265, June 2025.
Schematic representation of Trichoderma asperellum infection affects the flavonoid content in corn and influences the gut microbiota and juvenile hormone pathway of Conogethes punctiferalis larvae leading to growth inhibition. Summary Pathogen infection in host plants can alter the attraction and adaptability of herbivorous insects.
Qian Li, Jiayu Li, Kaining Wu, Yue Tong, Aihuan Zhang, Yanli Du   +5 more
wiley   +1 more source

In Vitro Psilocybin Synthesis by Co‐Immobilized Enzymes

Chemistry – A European Journal, Volume 31, Issue 29, May 22, 2025.
The drug candidate and psychedelic mushroom product psilocybin was produced by multienzyme‐charged beads in a biocatalytic cell‐free approach. Using immobilized fungal indolethylamine biosynthetic and additional bacterial enzymes, these beads turned over 4‐hydroxy‐l‐tryptophan to psilocybin.
Tim Schäfer, Alexander Sherwood, Thomas Kirkland, Thomas Krüger, Jakob Worbs, Olaf Kniemeyer, Markus Gressler, Dirk Hoffmeister   +7 more
wiley   +1 more source