Results 31 to 40 of about 69 (69)
ChemMedChem, Volume 20, Issue 9, May 5, 2025.The review focuses on relationships of oxadiazole derivative structures and their antimycobacterial activity including target structures in mycobacteria, in vitro or in vivo pharmacokinetic parameters, and toxicity. Apart from direct antimycobacterial activity, some 1,2,4‐oxadiazole derivatives can potentiate the antimycobacterial effect of ethionamide
Marta Kučerová‐Chlupáčová
wiley +1 more source
Advanced Science, Volume 12, Issue 18, May 15, 2025.This work summarizes the efficacy and mechanisms of probiotics in CRC treatment, providing a comprehensive overview of various encapsulation methods such as microcapsules, hydrogels, single‐cell nanocoatings, and nanofibers for targeted probiotic delivery to inflammatory sites, with particular emphasis on the potential advantages of emerging single ...
Hao Zhong +5 more
wiley +1 more source
Embracing the future: Neonatal screening for epileptic syndromes
Epilepsia, EarlyView.
Rima Nabbout, Mathieu Kuchenbuch
wiley +1 more source
Role of P2X7R in Retinal Diseases: A Review
Immunity, Inflammation and Disease, Volume 13, Issue 5, May 2025.ABSTRACT Background P2X purinoceptor 7 receptor (P2X7R) is an ATP‐gated ion channel that, upon activation by ATP, triggers the release of inflammatory mediators and induces apoptosis in cells. This channel plays a crucial role in the onset and progression of various diseases.
Chunli Li, Binsheng Wang
wiley +1 more source
Journal of Parenteral and Enteral Nutrition, Volume 49, Issue 4, Page 451-459, May 2025.Abstract Background Intestinal failure (IF) is a life‐limiting condition that includes a variety of intestinal pathologies. Currently, there are few clinical biomarkers that reflect intestinal function or a patient's potential to wean off parenteral nutrition (PN), making it difficult to predict the clinical trajectory.
Niklas Tappauf +3 more
wiley +1 more source
Human Pyridoxal Kinase: Overexpression and Properties of the Recombinant Enzyme
Molecules and Cells, 2000 Pyridoxal kinase catalyses the phosphorylation of the vitamin B6. A human brain pyridoxal kinase cDNA was isolated, and the recombinant enzyme was overexpressed in E. coli as a fusion protein with maltose binding protein (MBP). Pure pyridoxal kinase exhibits a molecular mass of about 40 kDa when examined by SDS-PAGE and FPLC gel filtration.
H S, Lee +3 more
openaire +2 more sources
Arrangement of the substrates at the active site of brain pyridoxal kinase.
Journal of Biological Chemistry, 1991 The distances between enzyme-bound paramagnetic CrATP (a stable, beta, gamma-bidentate complex of Cr3+ and ATP) at the active site of sheep brain pyridoxal kinase and the protons of bound inhibitor 4-dPyr (4-deoxypyridoxine) were determined in the ternary enzyme-CrATP.4-dPyr complex by measuring the paramagnetic effects of Cr3+ on the longitudinal ...
W F Wolkers +3 more
openaire +3 more sources
Inhibition of pyridoxal kinase by the pyridoxal-gamma-aminobutyrate imine. [PDF]
Journal of Biological Chemistry, 1980 D M Abercrombie, D L Martin
openaire +2 more sources
Association of pyridoxal kinase and Parkinson disease
Annals of Neurology, 2010 Krzysztof Czyzewski +17 more
openaire +4 more sources
Binding of a photoaffinity analogue of pyridoxal to pyridoxal kinase [PDF]
European Journal of Biochemistry, 1990 The binding of pyridoxal analogues to the structural domains of pyridoxal kinase was studied by fluorescence spectroscopy and chromatographic techniques. Two fragments of 24 and 16 kDa, arising from limited proteolysis of the native enzyme, were separated by ion‐exchange chromatography and used for binding studies with pyridoxal oxime.
Glen M. Scholz +2 more
openaire +2 more sources