Results 51 to 60 of about 888,200 (233)

PLPP/CIN-mediated NF2 S10 dephosphorylation distinctly regulates kainate-induced seizure susceptibility and neuronal death through PAK1-NF-κB-COX-2-PTGES2 signaling pathway

Journal of Neuroinflammation, 2023
Background Pyridoxal-5′-phosphate phosphatase/chronophin (PLPP/CIN) selectively dephosphorylates serine (S) 10 site on neurofibromin 2 (NF2, also known as merlin (moesin-ezrin-radixin-like protein) or schwannomin).
Ji-Eun Kim, Duk-Shin Lee, Tae-Hyun Kim, Hana Park, Min-Ju Kim, Tae-Cheon Kang   +5 more
doaj   +1 more source

Metabolic modeling predicts unique drug targets in Borrelia burgdorferi

mSystems, 2023
The Lyme disease bacterium Borrelia burgdorferi is extremely host dependent, with a small genome and correspondingly limited metabolism. As such, it is an excellent candidate for the development of targeted, narrow-spectrum antimicrobials.
Peter J. Gwynne, Kee-Lee K. Stocks, Elysse S. Karozichian, Aarya Pandit, Linden T. Hu   +4 more
doaj   +1 more source

Effect of cyclosporine on hepatic cytosolic estrogen and androgen receptor levels before and after partial hepatectomy [PDF]

, 1990
Estrogen and androgen receptors within the liver have been reported to modulate the hepatic regenerative response to partial hepatectomy. Moreover, cyclosporine has several untoward effects that might occur as a consequence of alterations in sex hormone ...
A Francavilla, A Francavilla, A. Francavilla, AK Roy, AM Hoyumpa, B Fisher, BA Stoll, CW Bardin, D Kahn, D. H. Van Thiel, D. Kahn, DH Thiel Van, F Kern Jr, G Klatskin, GC Chamness, GM Higgins, H. Lai, I Kam, J. S. Gavaler, JA Gustafsson, JA McGowan, JK Baum, L. Makowka, LE Porter, LJ Bennion, M Salizzori, OH Lowry, P. K. Eagon, PK Eagon, PK Eagon, RY Calne, SB Cardon, T. E. Starzl, TE Starzl   +33 more
core   +1 more source

Reversible unfolding of pyridoxal kinase.

Journal of Biological Chemistry, 1993
The unfolding of brain pyridoxal kinase by guanidinium HCl has been investigated at equilibrium. The overall process was reversible as judged from the complete recovery of catalytic activity after removal of guanidinium HCl. Unfolding of pyridoxal kinase was monitored by circular dichroism and fluorescence spectroscopy.
T, Pineda, J E, Churchich
openaire   +2 more sources

Effects of the CDK-inhibitor CYC202 on p38 MAPK, ERK1/2 and c-Myc activities in papillomavirus type 16 E6- and E7-transformed human keratinocytes [PDF]

, 2007
In the present study, we have investigated the effect of the chemical CDK-inhibitor CYC202 on E6 and E7-transformed keratinocytes, in which the function of the cellular cell cycle inhibitor p21Cip1 is abrogated by the viral genes.
Atanasova, Ganka, Isaeva, Antonia R., Mitev, Vanyo I., Poumay, Yves, Zhelev, Nikolai   +4 more
core   +2 more sources

Cyclosporine augments hepatic regenerative response in rats [PDF]

, 1990
A number of mechanisms participate in the hepatic injury that occurs during and following liver transplantation. A normal allograft regenerative response is probably essential for a successful transplant outcome. In this study, the effect of cyclosporine,
Dindzans, V, Eagon, PK, Kahn, D, Lai, H, Makowka, L, Starzl, TE, Van Thiel, DH   +6 more
core   +1 more source

Metabolic features of cancer cells impact immunosurveillance

Journal for ImmunoTherapy of Cancer, 2021
Background Tumors rewire their metabolism to achieve robust anabolism and resistance against therapeutic interventions like cisplatin treatment. For example, a prolonged exposure to cisplatin causes downregulation of pyridoxal kinase (PDXK), the enzyme ...
Christophe Klein, Diane Damotte, Alexandra Leary, Adrien Joseph, Sebastien Gouy, Marco Alifano, Marie-Caroline Dieu-Nosjean, Guido Kroemer, Eric Deutsch, Antoine Lafarge, Philippe Morice, Julien Adam, Patricia Pautier, Cyrus Chargari, Isabelle Cremer, Catherine Genestie, Pan Juncheng, Michele Mondini, Nizar Labaied, Mauro Loi, Valentina Astesana, Florine Obrist, Norma Bloy, Gautier Stoll, Nicolas Signolle, Maria Castedo   +25 more
doaj   +1 more source

Virtual Screening of Leishmanial Pyridoxal Kinase Enzyme Inhibitors by Repurposed Anti-Trypanosomal Libraries Reveals Two Core Scaffolds

, 2020
Leishmania is an intracellular protozoal infection, and it is classified as a neglected disease by the World Health Organization (WHO). Annually more than 2 million newly diagnosed cases were treated with highly toxic drugs.
Sanad Alfadhel
semanticscholar   +1 more source

An Evolutionary Marker of the Ribokinase Superfamily Is Responsible for Zinc-Mediated Regulation of Human Pyridoxal Kinase

Catalysts, 2020
The ribokinase superfamily catalyzes the phosphorylation of a vast diversity of substrates, and its members are characterized by the conservation of a common structural fold along with highly conserved sequence motifs responsible for phosphoryl transfer (
C. Ramírez-Sarmiento, Felipe Engelberger, V. Guixé   +2 more
semanticscholar   +1 more source

Chronophin regulates active vitamin B6 levels and transcriptomic features of glioblastoma cell lines cultured under non-adherent, serum-free conditions [PDF]

, 2018
Background: The phosphatase chronophin (CIN/PDXP) has been shown to be an important regulator of glioma cell migration and invasion. It has two known substrates: p-Ser3-cofilin, the phosphorylated form of the actin binding protein cofilin, and pyridoxal ...
Floßbach, Lucia, Herold-Mende, Christel, Hoja, Sabine, Hutterer, Maria, Lorenz, Julia, Monoranu, Camelia, Riemenschneider, Markus J., Rothhammer-Hampl, Tanja, Sabo, Anja, Schulze, Markus   +9 more
core   +3 more sources