Results 61 to 70 of about 888,200 (233)

Study on the Pyridoxal Kinase of Mouse Brain

THE JOURNAL OF VITAMINOLOGY, 1969
The properties of the pyridoxal kinase of mouse brain were studied and the following results were obtained.1. It was concluded that toxopyrimidine seemed to be phosphorylated by the same phosphokinase as pyridoxal based on the following reasons: the mutual competitive inhibition, the coincidence of the metal requirements, the denaturation effects of ...
M, Tsubosaka, K, Makino
openaire   +3 more sources

Prognostic Impact of Vitamin B6 Metabolism in Lung Cancer

Cell Reports, 2012
Patients with non-small cell lung cancer (NSCLC) are routinely treated with cytotoxic agents such as cisplatin. Through a genome-wide siRNA-based screen, we identified vitamin B6 metabolism as a central regulator of cisplatin responses in vitro and in ...
Lorenzo Galluzzi, Ilio Vitale, Laura Senovilla, Ken André Olaussen, Guillaume Pinna, Tobias Eisenberg, Aïcha Goubar, Isabelle Martins, Judith Michels, Gueorgui Kratassiouk, Didac Carmona-Gutierrez, Marie Scoazec, Erika Vacchelli, Frederic Schlemmer, Oliver Kepp, Shensi Shen, Maximilien Tailler, Mireia Niso-Santano, Eugenia Morselli, Alfredo Criollo, Sandy Adjemian, Mohamed Jemaà, Kariman Chaba, Claire Pailleret, Mickaël Michaud, Federico Pietrocola, Nicolas Tajeddine, Thibault de La Motte Rouge, Natalia Araujo, Nadya Morozova, Thomas Robert, Hugues Ripoche, Frederic Commo, Benjamin Besse, Pierre Validire, Pierre Fouret, Angélique Robin, Nicolas Dorvault, Philippe Girard, Sébastien Gouy, Patricia Pautier, Nora Jägemann, Ann-Christin Nickel, Sabrina Marsili, Caroline Paccard, Nicolas Servant, Philippe Hupé, Carmen Behrens, Parviz Behnam-Motlagh, Kimitoshi Kohno, Isabelle Cremer, Diane Damotte, Marco Alifano, Øivind Midttun, Per Magne Ueland, Vladimir Lazar, Philippe Dessen, Hans Zischka, Etienne Chatelut, Maria Castedo, Frank Madeo, Emmanuel Barillot, Juergen Thomale, Ignacio Ivan Wistuba, Catherine Sautès-Fridman, Laurence Zitvogel, Jean-Charles Soria, Annick Harel-Bellan, Guido Kroemer   +68 more
doaj   +1 more source

In vitro and in vivo miltefosine susceptibility of a Leishmania amazonensis isolate from a patient with diffuse cutaneous leishmaniasis. [PDF]

PLoS Neglected Tropical Diseases, 2014
Miltefosine was the first oral compound approved for visceral leishmaniasis chemotherapy, and its efficacy against Leishmania donovani has been well documented.
Adriano C Coelho, Cristiana T Trinconi, Carlos H N Costa, Silvia R B Uliana   +3 more
doaj   +1 more source

Affinity labeling of pyridoxal kinase with adenosine polyphosphopyridoxal.

Journal of Biological Chemistry, 1988
Pyridoxal kinase is inactivated by preincubation with the affinity label reagent adenosine tetraphosphate pyridoxal (AP4-PL) at a mixing molar ratio of 5:1 AP4-PL contains structural features of the substrates pyridoxal and ATP. The substrate ATP affords substantial protection against inactivation.
DOMINICI, Paola, G. SCHOLZ, F. KWOK, J. E. CHURCHICH   +3 more
openaire   +3 more sources

Breed and adaptive response modulate bovine peripheral blood cells’ transcriptome [PDF]

, 2015
Background: Adaptive response includes a variety of physiological modifications to face changes in external or internal conditions and adapt to a new situation.
SA Kinlein, MN Silverman, HA Selye, IJ Elenkov, PD Eckersall, SM Haeryfar, J Kent, JG Conner, A Horadagoda, A Dowling, SP Alsemgeest, P Jawor, M Amadori, C Cray, S Ranabir, S Hing, G Solano-Aguilar, KE McLoughlin, H Shin, R Weikard, A O’Loughlin, V Chai, ER Mardis, Z Wang, S Wickramasinghe, Y Han, M Bionaz, Institut National de la Recherche Agronomique, S Sgorlon, S Sgorlon, A Schroeder, S Sgorlon, GC Elsik, MI Love, Y Benjamini, DW Huang, A Sundrum, A Papadimitriou, JC Buckingham, T Kitajima, GP Chrousos, RS Weinstein, M Doga, Y Tamura, O Schakman, C Tsigos, P Anagnostis, AJ Rose, P Joseph-Bravo, NC Nicolaides, M Kaneisha, MC Hanna, MD Toney, NB Livanova, C Beedham, TK Kundu, J Sahi, E Garattini, H Li, JO Lundberg, M Izumi, P Hänzelmann, BI Labow, T Wen, T Ohto, JE Burke, T Schulz-Utermoehl, KC Patki, N Hanioka, R Harrison, A Ives, SJ Chung, OH Temmink, AB Kuilenburg Van, D Boraschi, K Oshimi, N Burdin, F Biet, Y Mukai, SG Pereira, ML Ponce, K Dib, JM Cook-Mills, J Sottile, KC DeHahn, A Kawakami, S Viriyakosol, I Sabroe, MA Hadders, Y Qiu, S Koyasu, AE Ting, S Christensen, AK Ekman, A Dufner, R Zhou, M Proell, LC Wang, J Dwyer, A Siritantikorn, SA Marchitti, AE Medvedev, Y Chen, N Heisterkamp, DO Morgan, JR Ingelfinger, ME Selsted, EM Kościuczuk, A Janowska-Wieczorek, B Vafadari, W Schrödl   +110 more
core   +1 more source

Biosynthesis of selenocysteine on its tRNA in eukaryotes.

PLoS Biology, 2007
Selenocysteine (Sec) is cotranslationally inserted into protein in response to UGA codons and is the 21st amino acid in the genetic code. However, the means by which Sec is synthesized in eukaryotes is not known.
Xue-Ming Xu, Bradley A Carlson, Heiko Mix, Yan Zhang, Kazima Saira, Richard S Glass, Marla J Berry, Vadim N Gladyshev, Dolph L Hatfield   +8 more
doaj   +1 more source

MicroRNA339 Targeting PDXK Improves Motor Dysfunction and Promotes Neurite Growth in the Remote Cortex Subjected to Spinal Cord Transection

Frontiers in Cell and Developmental Biology, 2020
Spinal cord injury (SCI) is a fatal disease that can cause severe disability. Cortical reorganization subserved the recovery of spontaneous function after SCI, although the potential molecular mechanism in this remote control is largely unknown ...
Liu-Lin Xiong, Liu-Lin Xiong, Liu-Lin Xiong, Yan-Xia Qin, Qiu-Xia Xiao, Yuan Jin, Mohammed Al-Hawwas, Zheng Ma, You-Cui Wang, Visar Belegu, Visar Belegu, Xin-Fu Zhou, Lu-Lu Xue, Ruo-Lan Du, Jia Liu, Xue Bai, Ting-Hua Wang, Ting-Hua Wang, Ting-Hua Wang   +18 more
doaj   +1 more source

Characterization of Two Kinases Involved in Thiamine Pyrophosphate and Pyridoxal Phosphate Biosynthesis in Bacillus subtilis : 4-Amino-5-Hydroxymethyl-2-Methylpyrimidine Kinase and Pyridoxal Kinase [PDF]

Journal of Bacteriology, 2004
ABSTRACT Two Bacillus subtilis genes encoding two proteins (currently annotated ThiD and YjbV) were overexpressed and characterized. YjbV has 4-amino-5-hydroxymethyl-2-methylpyrimidine and 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate kinase activity and should be reannotated ThiD, and
Joo-Heon, Park, Kristin, Burns, Cynthia, Kinsland, Tadhg P, Begley   +3 more
openaire   +2 more sources

Thyroid Hormone-Responsive Genes in Primary Cultures of Rat Hepatic Cells

DNA
Background/Objectives: Thyroid hormones are key regulators in hepatic metabolic pathways. Although they regulate various hepatic genes, only a few are known to be under direct transcriptional regulation through thyroid hormone receptors.
Nariaki Fujimoto, Shigeyuki Kitamura
doaj   +1 more source

ATP- and Adenosine-Mediated Signaling in the Central Nervous System: The Role of Extracellular ATP in Hippocampal Long-Term Potentiation

Journal of Pharmacological Sciences, 2004
Application of 10 μM ATP for 10 min transiently depressed, then slowly augmented, synaptic transmission in CA1 neurons, leading to long-term potentiation (LTP) (ATP-induced LTP).
Satoshi Fujii
doaj   +1 more source