Results 261 to 270 of about 58,002 (312)
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DRUG-PYRIDOXAL PHOSPHATE INTERACTIONS
Drug Metabolism and Drug Interactions, 1982In this review it has been pointed out that vitamin B6 and its vitamers can be involved in many interactions with a number of drugs, as well as with the actions of various endocrines and neurotransmitters. Nutritional deficiencies, especially of vitamins and proteins, can affect the manner in which drugs undergo biotransformation, and thereby may also ...
M, Ebadi, C F, Gessert, A, Al-Sayegh
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Fluorometric assay of pyridoxal and pyridoxal 5′-phosphate
Analytical Biochemistry, 1979Abstract A new and very sensitive fluorometric method for the determination of pyridoxal and pyridoxal 5′-phosphate is reported. The specificity is based on the reductive amination of pyridoxal and its 5′-phosphate with methyl anthranilate and sodium cyanoborohydride at pH 4,5 to 5,0.
M S, Chauhan, K, Dakshinamurti
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Pyridoxal phosphate: Biosynthesis and catabolism
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2011Vitamin B(6) is an essential cofactor that participates in a large number of biochemical reactions. Pyridoxal phosphate is biosynthesized de novo by two different pathways (the DXP dependent pathway and the R5P pathway) and can also be salvaged from the environment.
Mukherjee, Tathagata +4 more
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Inhibition of gaba binding by pyridoxal and pyridoxal phosphate
International Journal of Biochemistry, 1980Abstract 1. 1. GABA exerts its neuroinhibitory effects by binding to a specific receptor on the post-synaptic membrane. 2. 2. Since both GABA and vitamin B 6 have been implicated in convulsion, the effects of B 6 vitamers on Na-independent binding of GABA was investigated by incubating synaptic membrane suspensions for 5 min at 4°C in 1 ml ...
M, Ebadi, B, Klangkalya, J D, Deupree
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The interactions between biogenic amines and pyridoxal, pyridoxal phosphate, and pyridoxal kinase
Archives of Biochemistry and Biophysics, 1972Abstract The effect of biogenic amines on pyridoxal kinase activity has been investigated in vitro . Experiments with a purified beef brain pyridoxal kinase indicate that 3,4-dihydroxyphenylalanine (dopa), dopamine, norepinephrine, and serotonin inhibit the reaction, while tyrosine, tryptophan, and 5-hydroxytryptophan (5-HTP) have no effect. However,
J T, Neary +3 more
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Pyridoxal-5′-phosphate and pyridoxal biokinetics in aging Wistar rats
Experimental Gerontology, 1991Biokinetic parameters of plasma pyridoxal-5'-phosphate (PLP) and pyridoxal (PL) disposition were studied in male Wistar rats aged 8 and 27 months kept from weaning on a purified diet containing 250 g casein and 6 mg pyridoxine.HCl per kg. Baseline plasma PLP concentration was lower in the older animals (514 +/- 56 nmol/L for young and 317 +/- 124 nmol ...
Bode, W., Berg, H. van den
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Interaction between Pyridoxal Kinase and Pyridoxal-5-phosphate-Dependent Enzymes
Journal of Biochemistry, 2003The interactions of two pyridoxal-5-phosphate (PLP)-dependent enzymes, alanine aminotransferase (ALT) and glutamate decarboxylase (GAD), with pyridoxal kinase (PK) were studied by fluorescence polarization as well as surface plasmon resonance techniques. The results demonstrated that PK can specifically bind to ALT and GAD.
Pik-Yuen, Cheung +7 more
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Spectrophotometric determination of pyridoxal-5-phosphate
Analytica Chimica Acta, 1959Abstract A simple and specific spectrophotometric procedure for the estimation of pyridoxal-5-phosphate is described, based on the complete disappearance of the absorption maximum at 385 mμ following the incubation with potassium cyanide.
V, SCARDI, V, BONAVITA
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Polarographische bestimmung des pyridoxals und pyridoxal-5-phosphats
Journal of Electroanalytical Chemistry (1959), 1960The estimation of pyridoxal together with pyridoxal-5-phosphate has been carried out by two polarographic methods. The first method is based upon the varying heights of the pyridoxal waves between ph 2 and 9. Since the height of the wave of the pyridoxal-5-phosphate practically does not alter with the ph, the decrease in the wave height of the mixture ...
Osvald Manoušek, Petr Zuman
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Pyridoxal phosphate inhibition of platelet function
American Journal of Physiology-Heart and Circulatory Physiology, 1980The effect of pyridoxal phosphate (PLP) on human platelet function in vitro was studied. PLP inhibited adenosine diphosphate (ADP)-induced shape change, aggregation, and the potentiation by ADP of arachidonic acid-induced aggregation. This inhibition could easily be reversed by increasing concentrations of ADP or by removing PLP.
E, Kornecki, H, Feinberg
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