Results 91 to 100 of about 2,887,246 (174)

Current knowledge for pyridoxine-dependent epilepsy: a 2016 update

Expert Review of Endocrinology & Metabolism, 2016
Pyridoxine-dependent epilepsy (PDE) is a rare genetic condition characterized by intractable and recurrent neonatal seizures that are uniquely alleviated by high doses of pyridoxine (vitamin B6). This recessive disease is caused by mutations in ALDH7A1, a gene encoding Antiquitin, an enzyme central to lysine degradation.
Pena, Izebella Agostinho, Mackenzie, Alex, van Karnebeek, Clara D. M.   +2 more
openaire   +2 more sources

Effect of Nutritional Factors on Mental Health Problems in Autism Spectrum Disorder: A Narrative Synthesis of Current Evidence

Brain and Behavior, Volume 16, Issue 7, July 2026.
This narrative synthesis of 21 studies evaluates nutritional interventions for psychiatric comorbidities in ASD. Vitamin D3, omega‐3 fatty acids, and probiotics show preliminary benefits for anxiety and irritability, whereas GFCF diet results remain inconclusive.
Nalan Hakime Nogay, Gulin Ozturk Ozkan
wiley   +1 more source

Suicidal behavior and antiepileptic drugs in epilepsy: analysis of the emerging evidence [PDF]

, 2011
Marco Mula1, Dale C Hesdorffer21Department of Clinical and Experimental Medicine, Amedeo Avogadro University and Division of Neurology, University Hospital Maggiore della Carità, Novara, Italy; 2Gertrude H Sergievsky Center and Department of ...
Mula M, Mula, M, Hesdorffer DC, Hesdorffer, DC   +3 more
core   +1 more source

Pyridoxine-dependent epilepsy: an under-recognised cause of intractable seizures

, 2012
Pyridoxine-dependent epilepsy (PDE) is a rare autosomal recessive disorder causing intractable seizures in neonates and infants. PDE patients are typically resistant to anti-epileptic treatment but respond to the administration of pyridoxine.
Yeghiazaryan NS, Brigati G, Falsaperla R, Capovilla G, Zara F, Striano P   +5 more
core   +1 more source

Do We Need to Monitor B‐Vitamins and Homocysteine During Initiation of Foslevodopa/Foscarbidopa Therapy?

Movement Disorders, Volume 41, Issue 9, Page 2535-2537, September 2026.
Aida Shaghaghi‐Zadeh, Matthias Höllerhage, Florian Wegner, Lan Ye, Ishana Schneidereit, Tobias Hegelmaier, Rebecca Jacob, Christoph Schrader, Martin Klietz   +8 more
wiley   +1 more source

Refractory Seizures in a Neonate with a Rare Coexistence of Variants in Both ALDH7A1 and RHOBTB2 Genes

Indian Pediatrics Case Reports
Background: Pyridoxine-dependent epilepsy due to ALDH7A1 gene mutation is a known, but rare autosomal recessive disorder, presenting with early-onset, refractory seizures.
Kavya Rajanna, Mohit Ajmera, Swati Mehta, J. Suraj Kumar   +3 more
doaj   +1 more source

Is Vitamin B6 a Precision Therapy for Neonatal Seizures?

Neurology International
Background: Neonatal seizures are critical neurological events with long-term implications for brain development. Standard antiseizure medications, such as phenobarbital, often yield suboptimal seizure control and may be associated with neurotoxicity ...
Raffaele Falsaperla, Vincenzo Sortino, Bruna Scalia, Marco Andrea Nicola Saporito   +3 more
doaj   +1 more source

Report of the 2003 National Conference on Public Health and Epilepsy [PDF]

I. Executive Summary -- II. Introduction -- III. Living Well with Epilepsy II Conference -- -- IV. Review and Recommendations -- -- Workgroup A: Early Recognition, Diagnosis and Treatment -- -- Workgroup B: Epidemiology and Surveillance -- -- Workgroup C:
National Conference on Public Health and Epilepsy (2003 : Baltimore, MD)
core  

Triple therapy with pyridoxine, arginine supplementation and dietary lysine restriction in pyridoxine-dependent epilepsy: Neurodevelopmental outcome

, 2015
Pyridoxine-dependent epilepsy (PDE) is an epileptic encephalopathy characterized by response to pharmacologic doses of pyridoxine. PDE is caused by deficiency of alpha-aminoadipic semialdehyde dehydrogenase resulting in impaired lysine degradation and ...
Burns, Casey, van Hove, Johan L. K., Gallagher, Renata C., Coughlin, Curtis R., Shuen, Andrew Y., Gaughan, Sommer, van Karnebeek, Clara D. M., Jaggumantri, Sravan, Jack, Rhona M., Mirsky, David M., Al-Hertani, Walla   +10 more
core   +1 more source

Epidemiology of pyridoxine dependent seizures in the Netherlands.

, 2005
Item does not contain fulltextBACKGROUND: Pyridoxine dependent epilepsy is a rare cause of seizures in childhood. The diagnosis is made on clinical criteria, that in many cases are never met.
Been, J.V., Andriessen, Peter, Been, Jasper V, Bok, L A, Andriessen, P., Renier, W.O., Bok, L.A., Renier, WO   +7 more
core   +1 more source