Results 101 to 110 of about 3,547 (200)

Treatment of pediatric epilepsy

Pediatric Investigation, Volume 10, Issue 1, Page 86-100, February 2026.
Anti‐seizure medications are the first‐line treatment for the vast majority of children with epilepsy, with the advantages of non‐invasive wide adaptability. Surgery is the main treatment for drug‐resistant epilepsy and lesion‐related epilepsy, which can cure some cases of epilepsy in children. A ketogenic diet is often an add‐on therapy.
Junxiao Li, Tinghong Liu, Chang Liu, Jie Deng, Shijie Wu, Suhui Kuang, Xiaotong Li, Zhirong Wei, Shuli Liang   +8 more
wiley   +1 more source

Note clinique sur le traitement pharmacologique de l’autisme [PDF]

, 1998
Cet article fait le point sur la pharmacologie de l'autisme et en survole rapidement l'utilité, F historique et les nouveautés. L'« autisme » ne fait référence à aucune pathophysiologie présentement connue. Et aucun médicament ou classe de médicaments ne
Thivierge, Jacques
core   +1 more source

Pyridoxine dependent epilepsy: a suggestive electroclinical pattern [PDF]

Archives of Disease in Childhood - Fetal and Neonatal Edition, 2000
Editor—There are several problems with describing the electroclinical pattern in pyridoxine dependent seizures.1 One is defining the electrical features. Until now all published reports (including four of the five cases of Nabbout and colleagues) have described the electroencephalogram (EEG) in neonates who have received other anticonvulsants ...
openaire   +1 more source

Refractory Seizures in a Neonate with a Rare Coexistence of Variants in Both ALDH7A1 and RHOBTB2 Genes

Indian Pediatrics Case Reports
Background: Pyridoxine-dependent epilepsy due to ALDH7A1 gene mutation is a known, but rare autosomal recessive disorder, presenting with early-onset, refractory seizures.
Kavya Rajanna, Mohit Ajmera, Swati Mehta, J. Suraj Kumar   +3 more
doaj   +1 more source

Is Vitamin B6 a Precision Therapy for Neonatal Seizures?

Neurology International
Background: Neonatal seizures are critical neurological events with long-term implications for brain development. Standard antiseizure medications, such as phenobarbital, often yield suboptimal seizure control and may be associated with neurotoxicity ...
Raffaele Falsaperla, Vincenzo Sortino, Bruna Scalia, Marco Andrea Nicola Saporito   +3 more
doaj   +1 more source

Metabolische Epilepsien mit spezifischen Therapieoptionen: Diagnostischer Leitfaden [PDF]

, 2018
Zusammenfassung: Bei therapieresistenten Anfällen müssen, unabhängig vom jeweiligen Lebensalter, angeborene Stoffwechselerkrankungen erwogen werden.
Plecko, B.
core  

Genetic basis of hyperlysinemia [PDF]

, 2013
Background: Hyperlysinemia is an autosomal recessive inborn error of L-lysine degradation. To date only one causal mutation in the AASS gene encoding aminoadipic semialdehyde synthase has been reported.
Augoustides-Savvopoulou, P. (Persa), Baumgartner, M.R. (Matthias), Coşkun, T. (Turgay), Denis, S. (Simone), Duran, M. (Marinus), Houten, S.M. (Sander M.), Häberle, J. (Johannes), Klerk, J.B.C. (Johannes) de, Knegt, A.C. (Alida), Poll-The, B.T., Ruiter, J.P.N. (Jos), Sass, J.O. (Jörn Oliver), Te Brinke, H. (Heleen), Wanders, R.J.A. (Ronald), Zschocke, J. (Johannes)   +14 more
core   +1 more source

Current knowledge for pyridoxine-dependent epilepsy: a 2016 update

Expert Review of Endocrinology & Metabolism, 2016
Pyridoxine-dependent epilepsy (PDE) is a rare genetic condition characterized by intractable and recurrent neonatal seizures that are uniquely alleviated by high doses of pyridoxine (vitamin B6). This recessive disease is caused by mutations in ALDH7A1, a gene encoding Antiquitin, an enzyme central to lysine degradation.
Pena, Izebella Agostinho, Mackenzie, Alex, van Karnebeek, Clara D. M.   +2 more
openaire   +2 more sources

Treatment alternatives for Attention-Deficit/Hyperactivity Disorder (ADHD) [PDF]

, 1999
Objective: To review alternate treatments (Tx) of Attention-Deficit/Hyperactivity Disorder (ADHD)—those other than psychoactive medication and behavioral/psychosocial Tx—for the November, 1998 National Institute of Health (NIH) Consensus Development ...
Arnold, L. Eugene
core   +1 more source

Characterization of Two Distinct Structural Classes of Selective Aldehyde Dehydrogenase 1A1 Inhibitors. [PDF]

, 2015
Aldehyde dehydrogenases (ALDH) catalyze the irreversible oxidation of aldehydes to their corresponding carboxylic acid. Alterations in ALDH1A1 activity are associated with such diverse diseases as cancer, Parkinson?s disease, obesity, and cataracts ...
Hurley, Thomas D., Morgan, Cynthia A.
core   +1 more source