Results 101 to 110 of about 6,810 (200)

Pyridoxine Dependent Seizures-Report Of A Case And Brief Review Of Literature

Annals of Indian Academy of Neurology, 2002
Pyridoxine-dependent seizure is a rare autosornal recessive disorder that usually presents as neonatal intractable seizures. This syndrome is due to an inborn abnormality of the enzyme glutamic acid decarboxylase, which results in reduced pyridoxine ...
Rajesh R, Girija AS
doaj  

Biocatalytic synthesis of S‐adenosyl‐l‐methionine analogues for allosteric activation of cystathionine‐β‐synthase

The FEBS Journal, EarlyView.
Cystathionine‐β‐synthase (CBS) helps remove harmful homocysteine and supports the production of protective sulfur‐containing molecules. Using its natural activator, S‐adenosyl‐l‐methionine, as a template, we designed and tested 15 analogues. Three activated and stabilized the enzyme, including the newly identified S‐2‐amino‐adenosyl‐l‐methionine. These
Dalibor Nakládal, Žaneta Zajacová, Rick Oerlemans, Jana Havlikova, Gabriel Zorkócy, Lukáš Kerti, Katarína Sujová, Adrian Lengyel, Zoë van der Gun, Christina Yoseif, Adrianus Cornelis van der Graaf, Guido Krenning, Ján Kyselovič, Vladimír Frecer, Matthew R. Groves, Zdenko Levarski, André Heeres, Rob H. Henning, Leo E. Deelman   +18 more
wiley   +1 more source

Effect of pyridoxine in attenuating pulmonary pyroptosis induced by third-hand smoke exposure: An in silico and in vivo study in male Wistar rats

Journal of Advanced Biotechnology and Experimental Therapeutics
Third-hand smoke (THS) refers to the residual toxic substances that settle on surfaces following the combustion of tobacco. Although concerns about its health implications are increasing, studies exploring its impact on the lungs and potential protective
Astari Pranindya Sari, Reviono Reviono, Agus Dwi Susanto, Dono Indarto   +3 more
doaj   +1 more source

Vitamin B6: too much, too little, too late? An analysis of sales trends in Australia from 2023 to 2025

Internal Medicine Journal, EarlyView.
Abstract Background Peripheral neuropathy associated with vitamin B6 (pyridoxine) is dose and duration dependent. High‐dose vitamin B6 products associated with adverse neurological effects are available in Australia, prompting recent regulatory action to reschedule products containing ≥50 mg pyridoxine to schedule 3 (pharmacist only).
Wai‐Jo Jocelin Chan, Jennifer Hunter, Vivian Yeukman Lee, Rose Cairns, Slade Mathews, Joanna E. Harnett   +5 more
wiley   +1 more source

Long-term outcome in pyridoxine-dependent epilepsy.

, 2012
Item does not contain fulltextAim The long-term outcome of the Dutch pyridoxine-dependent epilepsy cohort and correlations between patient characteristics and follow-up data were retrospectively studied. Method Fourteen patients recruited from a national
Hoeven, J.H. van, Bok, Levinus A., Struys, Eduard, CORNELIS JAKOBS, Halbertsma, Feico J., Houterman, Saskia, Willemsen, Michel A., RON A WEVERS, MICHÈL A WILLEMSEN, SASKIA HOUTERMAN, Vreeswijk, C., Willemsen, M.A.A.P., Sival, Deborah A., LEVINUS A BOK, Houterman, S., FEICO J HALBERTSMA, Vreeswijk, Charlotte, Jakobs, Cornelis, Van der Hoeven, Johan H., Wevers, R.A., EDUARD STRUYS, JOHAN H VAN DER HOEVEN, Halbertsma, F.J., Sival, D.A., van der Hoeven, J.H., DEBORAH A SIVAL, Struys, E., Vreeswijk, C.M.J.M., Jakobs, C., Wevers, Ron A., Willemsen, M.A., CHARLOTTE VREESWIJK, Bok, L.A.   +32 more
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Activity of indicators of the humoral immunity unit of calves for the action of pyridoxine hydrochloride

, 2020
The article presents the data of the effect of different doses of pyridoxine hydrochloride on the activity of humoral immunity in the blood serum of calves of the dairy growing period.
R. Pelenio, V. Semanyuk, О. Jaremko, M. Verkholiuk, null null, R. Peleno   +5 more
core   +1 more source

Natural variation in the promoter of OsPDX1.2 enhances vitamin B6 accumulation and cold tolerance in rice

Journal of Integrative Plant Biology, EarlyView.
Allelic variation in the promoter of the pyridoxal phosphate synthase OsPDX1.2 caused variation in the ACE‐box cis‐elements, resulting in differing OsPDX1.2 expression due to differences in binding affinity between the OsbZIP18 transcriptipn factor and the ACE‐box, contributing to variation in vitamin B6 levels and cold tolerance among rice varieties ...
Bi Wang, Qiu Yi Wang, Wen Jie Shi, Rong Hui Li, Xu Dong Zhang, Li Ping Wang, Shi Jia Xia, Kai Xi Chen, Jun Jie Zhou, Yang Yang Sun, Jing He, Alisdair R. Fernie, Ying Chun Han, Jun Zhou Li, Yu Heng Shi, Xian Qing Liu, Yuan Yuan Zhang, Jie Luo, Cheng Jin   +18 more
wiley   +1 more source

Comparison of propofol, diazepam, and pyridoxine for isoniazid-induced seizures in Swiss albino mice

Toxicology Communications
Introduction Acute isoniazid toxicity causes refractory seizures due to pyridoxine deficiency-mediated gamma-aminobutyric acid depletion. While pyridoxine is the established antidote, its limited availability in emergency settings necessitates ...
Prinay Sohal, Kanchan Gupta, Sandeep Kaushal, Michael E. Mullins   +3 more
doaj   +1 more source

Pyridoxine toxicity: Report of a case

, 1984
Pyridoxine (vitamin B 6) is being widely prescribed for a variety of clinical entities, but there is little information in the literature regarding the safe use of the compound. A case report of megadose therapy resulting in toxicity is presented.
Vasile, A., Kornberg, Bruce, Goldberg, R.   +2 more
core  

Pyridoxine-Dependent Seizures and Intelligence

, 1996
Clinical manifestations, MRI abnormalities, learning disabilities, and effect of pyridoxine dose on intelligence quotients were studied in 6 definite and 3 possible cases of pyridoxine dependent seizures in children, ages 2.5 to 14 years, seen at ...
J Gordon Millichap, Millichap, J. Gordon
core   +1 more source