Results 101 to 110 of about 33,290 (259)

Pyridoxine Dependent Seizures-Report Of A Case And Brief Review Of Literature

Annals of Indian Academy of Neurology, 2002
Pyridoxine-dependent seizure is a rare autosornal recessive disorder that usually presents as neonatal intractable seizures. This syndrome is due to an inborn abnormality of the enzyme glutamic acid decarboxylase, which results in reduced pyridoxine ...
Rajesh R, Girija AS
doaj  

Comparison of propofol, diazepam, and pyridoxine for isoniazid-induced seizures in Swiss albino mice

Toxicology Communications
Introduction Acute isoniazid toxicity causes refractory seizures due to pyridoxine deficiency-mediated gamma-aminobutyric acid depletion. While pyridoxine is the established antidote, its limited availability in emergency settings necessitates ...
Prinay Sohal, Kanchan Gupta, Sandeep Kaushal, Michael E. Mullins   +3 more
doaj   +1 more source

Prebiotic aqueous reactions catalyzed by native nickel without hydrogen

The FEBS Journal, EarlyView.
Serpentinizing (H2‐producing) hydrothermal vents are candidate environments for metabolic origin. They generate highly reducing conditions that convert CO2 to formate and methane in abiotic reactions resembling reactions of the acetyl‐CoA pathway of CO2 fixation. They also contain natural catalysts. Native nickel (Ni0), like Fe0, Co0, and their alloys,
Carolina Garcia Garcia, Max Brabender, William F. Martin   +2 more
wiley   +1 more source

Red cell aspartate aminotransferase saturation with oral pyridoxine intake

São Paulo Medical Journal
CONTEXT AND OBJECTIVE: The coenzyme of aspartate aminotransferase is pyridoxal phosphate, generated from fresh vegetables containing pyridoxine. Vitamin B6-responsive sideroblastic anemia, myelofibrosis and Peyronie’s syndrome respond to high pyridoxine ...
Marilena Oshiro, Kimiyo Nonoyama, Raimundo Antônio Gomes Oliveira, Orlando Cesar de Oliveira Barretto   +3 more
doaj   +1 more source

Phenotypic characterization of Arabidopsis thaliana mutants that alleviate root growth defects in a vitamin B6 biosynthesis mutant

The FEBS Journal, EarlyView.
Vitamin B6 is a critical molecule for plant metabolism and development. Rsr4‐1, a loss‐of‐function mutant in a vitamin B6 biosynthesis gene, has a distinct short root phenotype. Here we describe five novel suppressor mutants with an rsr4‐1 background that have normalized root growth and distinct phenotypic and molecular characteristics, representing a ...
Marcelina Parra, Paige Henning, Clayton Bailes, Sanja Roje, Hanjo Hellmann   +4 more
wiley   +1 more source

A Scoping Review of 5-HT₃ Antagonist Antiemetic Medication Safety in the Management of Nausea and Vomiting of Pregnancy. [PDF]

Pharmacoepidemiol Drug Saf
ABSTRACT Purpose The prescribing of 5‐hydroxytryptamine 3 receptor and type 3 serotonin receptor (5‐HT3) antagonists, particularly ondansetron, for nausea and vomiting in pregnancy (NVP) has increased globally. However, evidence on the safety of these medications in pregnancy remains unclear.
Morgan S, Quintrell E, Russell DJ, Rhaman A, Gebremedhin A, Wyrwoll CS, Kelty E.   +6 more
europepmc   +2 more sources

Metabolic mRNA insufficiency of single cells: Implications for drug targeting and resistance

The FEBS Journal, EarlyView.
Because none of the single‐cell mRNA profiles of growing cell populations encoded any pathway towards cell growth, we used cluster‐averaged transcriptomes to estimate protein‐constrained Vmax's and identify (combinations of) subpopulation‐specific targets to overcome drug resistance. (Graphical Abstract was created in BioRender. Liu, Y. (2026). https://
Yanhua Liu, Hans V. Westerhoff
wiley   +1 more source

Pyridoxine-dependent seizures and microcephaly

, 2004
Pyridoxine dependency is a rare autosomal-recessive disorder causing intractable seizures in neonates and infants. This case report describes an infant with pyridoxine-dependent seizures with microcephaly and discusses a probable pathogenetic mechanism ...
Tan, HY, Fatih Kardaş, Karakelleoglu, C, Buyukavci, M, H.üseyin Tan, Kardas, F, Mustafa Büyükavcı, Cahit Karakelleoğlu   +7 more
core   +1 more source

Vitamin B6: too much, too little, too late? An analysis of sales trends in Australia from 2023 to 2025

Internal Medicine Journal, EarlyView.
Abstract Background Peripheral neuropathy associated with vitamin B6 (pyridoxine) is dose and duration dependent. High‐dose vitamin B6 products associated with adverse neurological effects are available in Australia, prompting recent regulatory action to reschedule products containing ≥50 mg pyridoxine to schedule 3 (pharmacist only).
Wai‐Jo Jocelin Chan, Jennifer Hunter, Vivian Yeukman Lee, Rose Cairns, Slade Mathews, Joanna E. Harnett   +5 more
wiley   +1 more source

Natural variation in the promoter of OsPDX1.2 enhances vitamin B6 accumulation and cold tolerance in rice

Journal of Integrative Plant Biology, EarlyView.
Allelic variation in the promoter of the pyridoxal phosphate synthase OsPDX1.2 caused variation in the ACE‐box cis‐elements, resulting in differing OsPDX1.2 expression due to differences in binding affinity between the OsbZIP18 transcriptipn factor and the ACE‐box, contributing to variation in vitamin B6 levels and cold tolerance among rice varieties ...
Bi Wang, Qiu Yi Wang, Wen Jie Shi, Rong Hui Li, Xu Dong Zhang, Li Ping Wang, Shi Jia Xia, Kai Xi Chen, Jun Jie Zhou, Yang Yang Sun, Jing He, Alisdair R. Fernie, Ying Chun Han, Jun Zhou Li, Yu Heng Shi, Xian Qing Liu, Yuan Yuan Zhang, Jie Luo, Cheng Jin   +18 more
wiley   +1 more source