Results 81 to 90 of about 6,810 (200)

Pyridoxine-dependent and other pyridoxine-responsive epilepsies—insights into phenotype overlapping and the long-term outcome in a cohort of 21 children

Frontiers in Neurology
AimEvaluation of etiology, phenotype, and long-term outcome, and defining the predictors of outcome in children with pyridoxine-responsive seizures.MethodsThe study included all children with pyridoxine-responsive seizures treated in our hospital from ...
Ružica Kravljanac, Biljana Vučetić Tadić, Vladimir Oparnica   +2 more
doaj   +1 more source

A pH‐Responsive fluorescence lifetime probe reveals GOT1 phase separation in cellular anti‐senescence

Smart Molecules, EarlyView.
Acidic pH triggers GOT1 phase separation via IDR1, recruiting ME1 to form ROS‐scavenging condensates that combat senescence, revealed by a FLIM‐based pH probe. Abstract Cellular senescence involves progressive acidification, but how cells sense and adapt to this pH shift remains unclear.
Ziyue Chen, Jiaqi Li, Yan Bao, Mengmeng Wang, Haoyan Chen, Mingjiong Zhang, Lina Ding, Shuangshuang Wu, Baoxing Shen   +8 more
wiley   +1 more source

Moderate pyridoxal phosphate deficiency enhances neuronal excitability and promotes calcium dysregulation

Frontiers in Neuroscience
ObjectivePyridoxal 5′-phosphate (PLP), the active form of pyridoxine (vitamin B6), is essential for converting glutamate into the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). Severe consequences of PLP deficiency due to genetic defects are
Valerie Girgis, Ashlyn Tharington, Jadyn Trivett, Sylvia Fitting, Rick B. Meeker, Clio Rubinos   +5 more
doaj   +1 more source

GLYCOSURIA IN PHLORIZINIZED RATS DEPLETED OF PYRIDOXINE

, 1948
Glucose excretion and dextrose: nitrogen ratios were measured following phlorizination in young fasting rats depleted of pyridoxine and in their pair-fed controls.
R. Gingras, Edouard Pagé
core   +1 more source

Modular Synthesis of α‐Quaternary Pyrrolines by Pyridoxal‐Catalyzed Sequential Reactions With Precise Chirality Relay

Transformative Chemistry, EarlyView.
Direct asymmetric α‐C conjugate addition of aminoacetonitrile enabled by carbonyl/iminium double activation, together with subsequent electrophilic functionalization, offers a one‐pot, two‐step modular strategy for synthesizing chiral α‐quaternary pyrrolines with precise chirality relay and high structural diversity.
Xingdie Yang, Pengwei Ji, Liang Liu, Tongyin Chen, Siqi Liu, Wen‐Wen Chen, Baoguo Zhao   +6 more
wiley   +1 more source

Homocystinuria: Reduced folate levels during pyridoxine treatment

, 1973
Homocystinuria: reduced folate levels during pyridoxine treatment. Nine patients with homocystinuria due to cystathionine synthase deficiency were treated with pyridoxine: 6 responded biochemically and 5 of these showed marked clinical improvement.
Brian Turner, Bridget Wilcken
core  

Differential Sperm DNA Methylation Profiles in Healthy Men With High Versus Low Adherence to the Mediterranean Diet in the Led‐Fertyl Study

Andrology, EarlyView.
ABSTRACT Background Diet is known to play an essential role not only in sperm quality but also in offspring health, likely mediated through the sperm epigenome. Moreover, one of the main components of the Mediterranean diet (MedDiet) (i.e., nuts) have shown to impact sperm DNA methylation patterns.
Rashmi Agarwal, Nancy Babio, Estefanía Davila‐Cordova, María Fernández de la Puente, Cristina Valle‐Hita, Carles Arribas, Manel Esteller, Aleix Noguera‐Castells, Raquel Pluvinet, Jordi Salas‐Salvadó, Albert Salas‐Huetos   +10 more
wiley   +1 more source

MORPHOFUNCTIONAL CHARACTERISTICS OF FIBROBLASTS (MCCOY CELL LINE) CULTURED WITH MAGNESIUM PREPARATIONS

Рациональная фармакотерапия в кардиологии, 2015
Aim. To study the effect of magnesium orotate, magnesium/pyridoxine combination and magnesium sulfate on fibroblast morphofunctional characteristics in cell culture of fibroblasts (McCoy line).Material and methods.
L. V. Didenko, T. G. Borovaya, E. A. Kost, E. A. Ulubieva, A. V. Timofeeva, A. G. Avtandilov   +5 more
doaj   +1 more source

Effect of dyes on the photodecomposition of pyridoxine and pyridoxamine

, 1981
Erythrosine, eosine Y, rose bengal, mercurochrome, methylene blue, azure A and azure B accelerated the photodecomposition of pyridoxine and pyridoxamine at pH 5–9, but fluorescein and acid red did not. The photodecomposition of pyridoxine in the presence
EMIKO MORITA, ASAMI FUJIWARA, NOBUYASU MIZUNO   +2 more
core   +1 more source

Dystrophia Smolandiensis is characterized by a novel NQO1 variant and a distinct phenotype from COL17A1‐associated epithelial recurrent erosion dystrophy

Acta Ophthalmologica, EarlyView.
Abstract Purpose To determine the molecular cause of the two epithelial recurrent erosion dystrophies, Dystrophia Smolandiensis and Dystrophia Helsinglandica, and to identify phenotypic differences between the two conditions. Methods DNA samples and clinical data from structured interview records were obtained from the Swedish families in which ...
Karl De Geer, Kristina Lagerstedt‐Robinson, Daniel Nilsson, Cilla Söderhäll, Björn Hammar, Erik Björck   +5 more
wiley   +1 more source