Results 141 to 150 of about 6,810 (200)
Dorsal ischaemic myelopathy in a dog: A case of unilateral, focal predominantly sensory loss
Abstract A 3‐year‐3‐month‐old, neutered, male Great Dane was presented with peracute left hindlimb monoparesis. Although voluntary movement was present, the dog was effectively non‐ambulatory due to its size. Proprioception, nociception and spinal reflexes were absent in the left hindlimb, localising the lesion to a left L4–S1 myelopathy.
Alexandra Ayoub +3 more
wiley +1 more source
Pitfalls in diagnosing and long‐term management of ceroid lipofuscinosis NCL4A in a mixed‐breed dog
Abstract An 8‐year‐old, spayed, female, mixed‐breed dog was presented with a 9‐month history of occasionally stumbling on walks, having difficulty navigating stairs and jumping into the car. A prior computed tomography scan of the head revealed mild leptomeningeal enhancement and suggested meningoencephalitis.
Ingeborg Hein +3 more
wiley +1 more source
In this exploratory case–control study, plasma PLP (vitamin B6), homocysteine and ACTH concentrations did not differ between patients with burning mouth syndrome (BMS) and controls, and none discriminated patients individually. Within patients, however, psychological distress mapped onto a homocysteine–ACTH relationship from which PLP appeared ...
Ashley Lebel +3 more
wiley +1 more source
Novel Amino Acid Changes Increase Phosphoenolpyruvate Carboxylase Output in planta
ABSTRACT Characterization of previously reported Arabidopsis mutants with increased aluminum (Al) resistance (alr) resulting from greater release of Al‐chelating malate identified three unique amino acid substitutions that each impacts PHOSPHOENOLPYRUVATE CARBOXYLASE 1, a key anaplerotic carbon fixation enzyme.
Jinrui Sheng +7 more
wiley +1 more source
Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley +1 more source
One Hundred Years of Sulfido Ligand in the Molybdenum Cofactor: New Perspectives
The terminal sulfido ligand in mononuclear molybdoenzymes has been appreciated for almost 125 years, with the characterization of Schardinger's enzyme in cow's milk, now known to be xanthine oxidase, that was isolated in 1902 in Vienna, Austria. The ligand is found in molybdoenzymes identified across all kingdoms of life.
Silke Leimkühler +2 more
wiley +1 more source
Pyridoxine-responsive PH1: Treatment
Owing to the rarity of PH, the efficacy of pyridoxine therapy has only been tested in very small series of patients. From two recent reports including 18 patients, 50% of patients would be unresponsive to pyridoxine whereas oxaluria would be normalized ...
Toussaint, Charles
core
Pyridoxine in clinical toxicology: a review.
Pyridoxine (vitamin B6) is a co-factor in many enzymatic pathways involved in amino acid metabolism: the main biologically active form is pyridoxal 5-phosphate. Pyridoxine has been used as an antidote in acute intoxications, including isoniazid overdose,
Gris, Mireille +2 more
core
The EEG Response to Pyridoxine-IV Neither Identifies nor Excludes Pyridoxine-Dependent Epilepsy
Contains fulltext : 89020.pdf (Publisher’s version ) (Open Access)PURPOSE: Pyridoxine-dependent epilepsy (PDE) is characterized by therapy-resistant seizures (TRS) responding to intravenous (IV) pyridoxine.
Natasha Maurits +2 more
exaly +2 more sources

