Potential Vitamin B6 Depletion During Carbidopa/Levodopa Therapy in Parkinson's Disease: A Scoping Review of Direct Evidence. [PDF]
Sielaff P +13 more
europepmc +1 more source
ABSTRACT Background and Aims Doxorubicin‐cyclophosphamide (AC) chemotherapy induces hepatotoxicity through oxidative stress and inflammatory pathway activation, but prospective African data are lacking and conventional liver tests may miss subclinical injury.
Tamrat Nida, Abdisa Tufa Bedada
wiley +1 more source
Metabolic feature profiling and metabolic vulnerability in acute lymphoblastic leukemia
For the first time, our study develops a novel metabolic classification and subtyping program, metabolic reprogramming‐based classifier for acute lymphoblastic leukemia, using internal PDT‐ALL‐2016 and external cohorts, which dissects metabolic profiling, clinical outcome, and therapeutic vulnerability for precision metabolic intervention in ALL ...
Xiaojie Liang +13 more
wiley +1 more source
Cobalamin-Related Remethylation Disorders: Pregnancy Outcomes and Prenatal Treatment-New Cases and a Literature Study. [PDF]
Stepien KM +22 more
europepmc +1 more source
Alcohol metabolism induces structural instability of iron‐sulfur clusters through ROS‐mediated oxidative damage and direct covalent modification of acetaldehyde. The iron‐sulfur cluster deficiency drives metabolic reprogramming by inactivating aconitase, accumulating succinate, and impairing tRNA thiolation, thereby promoting hepatic steatosis ...
Li Xu +6 more
wiley +1 more source
A diagnostic pitfall in iron-refractory microcytic hypochromic anemia with acquired ring sideroblasts initially treated as iron deficiency anemia-a case report. [PDF]
Liu X +5 more
europepmc +1 more source
Suppression of BDNF‐TrkB signaling has shown a protective trend on hepatic oxidative stress by reducing sucrose‐induced lipid peroxidation. BDNF–TrkB signaling pathway plays a peripheral role in regulating mitochondrial enzyme capacity and redox balance in the liver.
Akın Bodur +4 more
wiley +1 more source
Primary hyperoxaluria type 1-current practice in the siRNA era: an ERA Genes & Kidney Working Group survey. [PDF]
Bartram MP +16 more
europepmc +1 more source
Nuclear‐Spin Hyperpolarization of Biomolecules by Optically Enhanced NMR at Ultra‐High Field
This study shows that the sensitivity of liquid‐state NMR spectroscopy can be dramatically increased, with enhancement factors up to 160‐fold on a 1.1 GHz ultra‐high‐field NMR spectrometer. This advance exploits low‐concentration photochemically induced dynamic nuclear polarization (LC‐photo‐CIDNP) and it enables facile atomic‐resolution detection of ...
Ji Ho Jeong +2 more
wiley +1 more source
Thoracic Aortic Dissection in a Patient With Classical Homocystinuria: Implications for Aortic Surveillance. [PDF]
Chard M, Zhang JS, Turner L.
europepmc +1 more source

