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Vitamin B-6-Induced Neuropathy: Exploring the Mechanisms of Pyridoxine Toxicity
Vitamin B-6 in the form of pyridoxine (PN) is commonly used by the general population. The use of PN-containing supplements has gained lots of attention over the past years as they have been related to the development of peripheral neuropathy.
Misha F Vrolijk
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Oxidative stress is a major pathogenic mechanism in Parkinson’s disease (PD). As an important cellular antioxidant, glutathione (GSH) balances the production and incorporation of free radicals to protect neurons from oxidative damage.
Ming Xiao, Gang Hu
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Pyridoxine and Schizophrenia [PDF]
Luigi Bucci
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Hypersensitivity to Vitamins, 2021
All forms except pyridoxic acid[2] and pyritinol can be interconverted. Absorbed pyridoxamine is converted to PMP by pyridoxal kinase, which is further converted to PLP by pyridoxamine-phosphate transaminase or pyridoxine 5′-phosphate oxidase which also ...
Gianfranco Calogiuri
semanticscholar +1 more source
All forms except pyridoxic acid[2] and pyritinol can be interconverted. Absorbed pyridoxamine is converted to PMP by pyridoxal kinase, which is further converted to PLP by pyridoxamine-phosphate transaminase or pyridoxine 5′-phosphate oxidase which also ...
Gianfranco Calogiuri
semanticscholar +1 more source
Pyridoxine-Dependent Epilepsy in Zebrafish Caused by Aldh7a1 Deficiency
Pyridoxine-dependent epilepsy (PDE) is a severe neonatal seizure disorder and is here modeled in aldh7a1 -/- zebrafish. Mutant larvae display spontaneous..
Devon L Johnstone +2 more
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Pyridoxine 5′-phosphate oxidase (PNPO) is an enzyme that converts pyridoxine 5′-phosphate into pyridoxal 5′-phosphate (PLP), an active form of vitamin B6 implicated in several types of cancer.
Daibing Zhou, Jinguo Zhang, Tiankui Qiao
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Medical Journal of Australia, 1987
A case of sensory neuropathy in a young woman due to long-term ingestion of pyridoxine, with subsequent recovery, is described. Pyridoxine neuropathy may occur after the long-term ingestion of doses as low as 200 mg a day. Because of its widespread use in the community, both the general public and the medical community need to be aware of this recently
J A, Waterston, B S, Gilligan
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A case of sensory neuropathy in a young woman due to long-term ingestion of pyridoxine, with subsequent recovery, is described. Pyridoxine neuropathy may occur after the long-term ingestion of doses as low as 200 mg a day. Because of its widespread use in the community, both the general public and the medical community need to be aware of this recently
J A, Waterston, B S, Gilligan
openaire +2 more sources

