Results 1 to 10 of about 19,913 (244)

Effects of Pyridoxine Deficiency on Hippocampal Function and Its Possible Association with V-Type Proton ATPase Subunit B2 and Heat Shock Cognate Protein 70 [PDF]

Cells, 2020
Pyridoxine, one of the vitamin B6 vitamers, plays a crucial role in amino acid metabolism and synthesis of monoamines as a cofactor. In the present study, we observed the effects of pyridoxine deficiency on novel object recognition memory.
Hyo Young Jung, Woosuk Kim, Kyu Ri Hahn, Hyun Jung Kwon, Sung Min Nam, Jin Young Chung, Yeo Sung Yoon, Dae Won Kim, Dae Young Yoo, In Koo Hwang   +9 more
doaj   +4 more sources

Pyridoxine deficiency modulates benzene inhalation-induced hematotoxicity associated with hepatic CYP2E1 activity in B6C3F1 mice [PDF]

Toxicology Reports, 2021
Pyridoxine is a co-factor in many enzymatic reactions and impacts of deficiency have been observed in affected populations. A possible modifying effect of pyridoxine deficiency on benzene toxicity was assessed in male B6C3F1 mice fed either a pyridoxine ...
Chanthana Tangjarukij, Daam Settachan, Judith T. Zelikoff, Panida Navasumrit, Mathuros Ruchirawat   +4 more
doaj   +2 more sources

Biochemical data from the characterization of a new pathogenic mutation of human pyridoxine-5'-phosphate oxidase (PNPO) [PDF]

Data in Brief, 2017
PNPO deficiency is responsible of severe neonatal encephalopathy, responsive to pyridoxal-5′-phosphate (PLP) or pyridoxine. Recent studies widened the phenotype of this condition and detected new genetic variants on PNPO gene, whose pathogenetic role ...
Martino L. di Salvo, Mario Mastrangelo, Isabel Nogués, Manuela Tolve, Alessandro Paiardini, Carla Carducci, Davide Mei, Martino Montomoli, Angela Tramonti, Renzo Guerrini, Roberto Contestabile, Vincenzo Leuzzi   +11 more
doaj   +4 more sources

Moderate pyridoxal phosphate deficiency enhances neuronal excitability and promotes calcium dysregulation [PDF]

Frontiers in Neuroscience
ObjectivePyridoxal 5′-phosphate (PLP), the active form of pyridoxine (vitamin B6), is essential for converting glutamate into the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). Severe consequences of PLP deficiency due to genetic defects are
Valerie Girgis, Ashlyn Tharington, Jadyn Trivett, Sylvia Fitting, Rick B. Meeker, Clio Rubinos   +5 more
doaj   +2 more sources

Adjunctive Multicomponent Crystals of Two Anti-Tubercular Drugs with Pyridoxine [PDF]

Pharmaceutics
Background/Objectives: Cocrystallisation is a well-established path for altering the physicochemical properties and bioavailability of active pharmaceutical ingredients (APIs). A common side effect of anti-tubercular medicines is the depletion of group B
Tsebang A. Matlapeng, Theodor E. Geswindt, Roderick B. Walker, Vincent J. Smith   +3 more
doaj   +2 more sources

Liver Transplantation in PNPO Deficiency: Management Challenges and Biological Lessons [PDF]

JIMD Reports
Pyridox(am)ine 5′ Phosphate Oxidase deficiency (PNPO) presents with refractory epilepsy responsive to treatment with pyridoxal 5′ phosphate (PLP) or pyridoxine.
Richard Webster, Bindu Parayil Sankaran, Sushil Bandodkar, Michael Stormon, Gordon Thomas, Albert Shun, David Geoffrey Bowen, Timothy Fielder, Peter Barclay, Youssef Khalil, Philippa Mills, Peter Clayton, Kaustuv Bhattacharya   +12 more
doaj   +2 more sources

Impact of vitamin B6 deficiency on the severity of diabetic peripheral neuropathy – A cross sectional study

Saudi Pharmaceutical Journal, 2023
Background: Diabetic Peripheral Neuropathy is one of the most important and significantly prevalent microvascular complications of Diabetes Mellitus. Pyridoxine is a key nutrient for protecting nerve health. The objective of this research is to study the
Moteb Khobrani, Geetha Kandasamy, Rajalakshimi Vasudevan, AbdulAziz Alhossan, Ranadheer Chowdary Puvvada, Praveen Devanandan, Rajeshri Dhurke, Manusri Naredla   +7 more
doaj   +1 more source

A Rare Presentation Characterized by Epileptic Spasms in ALDH7A1, Pyridox(am)ine-5′-Phosphate Oxidase, and PLPBP Deficiency

Frontiers in Genetics, 2022
Objective: To analyze the clinical feature, treatment, and prognosis of epileptic spasms (ES) in vitamin B6–dependent epilepsy, including patients with pyridoxine-dependent epilepsy (PDE) caused by ALDH7A1 mutation, pyridox(am)ine-5′-phosphate oxidase ...
Xianru Jiao, Pan Gong, Yue Niu, Yuehua Zhang, Zhixian Yang   +4 more
doaj   +1 more source

ACUTE IZONIAZID POISONING WITH PRESENTATION OF A CLINICAL CASE [PDF]

Journal of IMAB, 2022
Rimicid or isonide a group of medications which belong to anti-tuberculosis medicaments. The active substance isoniazid is used to treat pulmonary and extrapulmonary forms of tuberculosis, as well as prophylaxis in case of contact with infected ...
Evgenia Barzashka, Vasil Atanasov, Teodora Valova, Olimpiada Atmazhova   +3 more
doaj   +1 more source

Pyridoxine-Dependent Epilepsy and Antiquitin Deficiency Resulting in Neonatal-Onset Refractory Seizures

Brain Sciences, 2021
Pyridoxine-dependent epilepsy (PDE) is an autosomal recessive neurometabolic disorder due to a deficiency of α-aminoadipic semialdehyde dehydrogenase (mutation in ALDH7A1 gene), more commonly known as antiquitin (ATQ).
Konrad Kaminiów, Magdalena Pająk, Renata Pająk, Justyna Paprocka   +3 more
doaj   +1 more source