Results 81 to 90 of about 1,692 (191)

Genetic deficiency of carnitine/organic cation transporter 2 (slc22a5) is associated with altered tissue distribution of its substrate pyrilamine in mice

Carnitine/organic cation transporter 2 (OCTN2) recognizes various cationic compounds as substrates in vitro, but information on its pharmacokinetic role in vivo is quite limited.
Kato, Sayaka, Kato, Yukio, Nakamura, Tadakatsu, Tsuji, Akira, Sugiura, Tomoko, Kubo, Yoshiyuki, Deguchi, Yoshiharu   +6 more
core  

Elucidating the roles of TM7SF3 and LHFPL6 in the putative H +/OC antiporter function in the human brain capillary endothelial cell line, hCMEC/D3.

INTRODUCTION: The putative proton/organic cation (H +/OC) antiporter has been shown to mediate transport of CNS drug compounds like oxycodone and pyrilamine across the blood-brain barrier (BBB).
Schmid, Benjamin, Kristensen, Mie, Kurosawa, Toshiki, Tabata, Hidetsugu, Brodin, Birger, Saaby, Lasse, Terasaki, Tetsuya, Svane, Nana, Kubo, Yoshiyuki, Deguchi, Yoshiharu   +9 more
core   +1 more source

Histamine H1-receptor-mediated keratan sulfate production in rabbit chondrocytes: involvement of protein kinase C

, 1991
We investigated the characteristics of the histamine H1-receptor in cultured rabbit chondrocytes. Scatchard analysis of [3H]pyrilamine, an H1-antagonist, binding to the chondrocytes revealed a single class of binding sites with KD and Bmax values of 90 +/
T. Kuno, K. Fukuda, F. Matsumura, S. Tanaka, H. Yamasaki, H. Motoyoshi, Y. Nagata   +6 more
core   +1 more source

Effect of histamine H1 and H2 receptor antagonists on histamine-induced macrophage LOX-1 mRNA expression.

, 2014
Monocyte-derived macrophages were incubated in the presence of 10 µM histamine and the indicated concentrations of the histamine H1 and H2 receptor antagonists (pyrilamine and ranitidine, respectively) for 4 h and analyzed for LOX-1 mRNA expression.
Petri T. Kovanen (188189), Mervi Alanne-Kinnunen (633861), Katariina Öörni (221897), Jani Lappalainen (245191)   +3 more
core   +1 more source

Characterization of histamine receptors mediating contraction and relaxation of the ovarian follicle wall

, 1987
Histamine is known to be present in ovarian tissue and may play a role in the ovulation process. The effect of histamine on the follicular smooth musculature was investigated using strips from the protruding part of mature bovine follicles, mounted in ...
Owman, Ch, Kannisto, P., Schmidt, G., Walles, B.   +3 more
core   +1 more source

Vasopeptidase-activated latent ligands of the histamine receptor-1

, 2013
Whether peptidases present in vascular cells can activate prodrugs active on vascular cells has been tested with 2 potential latent ligands of the histamine H1 receptor (H1R). First, a peptide consisting of the antihistamine cetirizine (CTZ) condensed at
Marceau, François, Charest-Morin??, Xavier, Gera, Lajos, Roy, Caroline   +3 more
core   +1 more source

EFFECTS OF H1- AND H2- RECEPTOR ANTAGONISTS ON THE HISTAMINE- AND HISTAMINE AGONISTS- INDUCED RESPONSE IN THE ISOLATED GUINEA PIG INTESTINE DURING ONTOGENY

, 1990
THE PURPOSE OF THE PRESENT INVESTIGATION WAS TO STUDY THE EFFECTS OF H1- AND H2- ANTAGONISTS ON THE CONTRACTIONS INDUCED BY HISTAMINE AS WELL AS BY HISTAMINE AGONISTS IN INTESTINAL SMOOTH MUSCLE OF GUINEA PIG DURING DEVELOPMENT.
Koutsoviti-Papadopoulou, Maria, Κουτσοβίτη-Παπαδοπούλου, Μαρία   +1 more
core   +1 more source

Proteomics-Based Transporter Identification by the PICK Method: Involvement of TM7SF3 and LHFPL6 in Proton-Coupled Organic Cation Antiport at the Blood-Brain Barrier. [PDF]

Pharmaceutics, 2022
Kurosawa T, Tega Y, Uchida Y, Higuchi K, Tabata H, Sumiyoshi T, Kubo Y, Terasaki T, Deguchi Y.   +8 more
europepmc   +1 more source

Neurotransmitters of sleep and wakefulness in flatworms. [PDF]

Sleep, 2022
Omond SET, Hale MW, Lesku JA.
europepmc   +1 more source

Simultaneous activation of CXC chemokine receptor 4 and histamine receptor H1 enhances calcium signaling and cancer cell migration. [PDF]

Sci Rep, 2023
Park C, Lee JW, Kim K, Seen DS, Jeong JY, Huh WK.   +5 more
europepmc   +1 more source