Results 111 to 120 of about 43,381 (288)

Ein neuer Malariawirkstoff hemmt die Proteinsynthese von Plasmodium falciparum

Angewandte Chemie, Volume 137, Issue 49, December 1, 2025.
Die Verbindung 31 stellt einen vielversprechenden Ansatz für die Entwicklung eines Malariawirkstoffs mit einem starken Wirkungsprofil dar (PfNF54 IC50 ± s.d. = 3,9 ± 0,4 nM). Sie hat einen neuartigen Wirkmechanismus, indem sie an zytosolische Ribosomen‐Untereinheiten bindet und dadurch die Proteinsynthese im Parasiten hemmt.
Patricia Bravo, Eleonora Diamanti, Mostafa M. Hamed, Lorenzo Bizzarri, Natalie Wiedemar, Armin Passecker, Nicolas M. B. Brancucci, Anna Albisetti, Christin Gumpp, Boris Illarionov, Markus Fischer, Matthias Witschel, Tobias Schehl, Hannes Hahne, Pascal Mäser, Matthias Rottmann, Anna K. H. Hirsch   +16 more
wiley   +1 more source

BONCAT-iTRAQ Labelling Reveals Molecular Markers of Adaptive Responses in Toxoplasma gondii to Pyrimethamine Treatment

Pathogens
We employed a BONCAT-iTRAQ labelling approach to investigate newly synthesised proteins (NSPs) in Toxoplasma gondii subjected to varying concentrations of the antifolate drug pyrimethamine.
John G. Mina, Anutthaman Parthasarathy, Exequiel O. Porta, Paul W. Denny, Karunakaran Kalesh   +4 more
doaj   +1 more source

Effect of Propranolol Alone and in Combination with Pyrimethamine on Acute Murine Toxoplasmosis

Jundishapur Journal of Microbiology, 2015
Background: Toxoplasmosis is a public health problem worldwide. This complication principally affects immunodeficient patients and pregnant women.
M. Montazeri, A. Daryani, M. Ebrahimzadeh, E. Ahmadpour, M. Sharif, S. Sarvi   +5 more
semanticscholar   +1 more source

A Novel Antimalarial Agent that Inhibits Protein Synthesis in Plasmodium falciparum

Angewandte Chemie International Edition, Volume 64, Issue 49, December 1, 2025.
Compound 31 represents a promising avenue for the development as an antimalarial agent with a potent activity profile (PfNF54 IC50 ± s.d. = 3.9 ± 0.4 nM). It has a novel mode of action by binding to cytosolic ribosomal subunits, thereby inhibiting protein synthesis in the parasite.
Patricia Bravo, Eleonora Diamanti, Mostafa M. Hamed, Lorenzo Bizzarri, Natalie Wiedemar, Armin Passecker, Nicolas M. B. Brancucci, Anna Albisetti, Christin Gumpp, Boris Illarionov, Markus Fischer, Matthias Witschel, Tobias Schehl, Hannes Hahne, Pascal Mäser, Matthias Rottmann, Anna K. H. Hirsch   +16 more
wiley   +1 more source

Novel use Of Hydroxyurea in an African Region with Malaria (NOHARM): a trial for children with sickle cell anemia [PDF]

, 2017
Hydroxyurea treatment is recommended for children with sickle cell anemia (SCA) living in high-resource malaria-free regions, but its safety and efficacy in malaria-endemic sub-Saharan Africa, where the greatest sickle-cell burden exists, remain unknown.
Hodges, James S., Hume, Heather A., John, Chandy C., Kasirye, Phillip, Lane, Adam, Latham, Teresa S., Ndugwa, Christopher M., Opoka, Robert O., Ware, Russell E.   +8 more
core   +2 more sources

Effect of monthly intermittent preventive treatment with dihydroartemisinin–piperaquine with and without azithromycin versus monthly sulfadoxine–pyrimethamine on adverse pregnancy outcomes in Africa: a double-blind randomised, partly placebo-controlled trial

, 2023
Mwayiwawo Madanitsa, Hellen C. Barsosio, Daniel T. R. Minja, George Mtove, Reginald A. Kavishe, James Dodd, Queen Saidi, Eric D Onyango, Kephas Otieno, Duolao Wang, Per Ashorn, Achille Massougbodji, Crispin Mukerebe, Samwel Gesase, Omari Abdul Msemo, Victor Mwapasa, Kamija S. Phiri, Kenneth Maleta, Nigel Klein, Pascal Magnussen, John Lusingu, Simon Kariuki, Jacklin F Mosha, Michael Alifrangis, Helle Hansson, Christentze Schmiegelow, Julie Gutman, R Matthew Chico, Feiko O. ter Kuile   +28 more
openalex   +1 more source

The Risk of Recrystallization: Changes to the Toxicity and Morphology of Pyrimethamine

Journal of Pharmacy & Pharmaceutical Sciences, 2014
PURPOSE. Pyrimethamine, an anti-malarial agent known to exhibit solid state polymorphism, may be purified by means of recrystallization. Recrystallization may alter the solid state chemistry of pharmaceuticals, which may impact the toxicity and/or ...
Zak Perold, Mino R Caira, Marius Brits
doaj   +1 more source

Supervised versus unsupervised antimalarial treatment with six-dose artemether-lumefantrine: pharmacokinetic and dosage-related findings from a clinical trial in Uganda. [PDF]

, 2006
BACKGROUND: A six-dose antimalarial regimen of artemether-lumefantrine (A/L) may soon become one of the most widely used drug combination in Africa, despite possible constraints with adherence and poor absorption due to inadequate nutrition, and a lack ...
Babigumira, J, Bajunirwe, F, Biraro, S, Checchi, F, Ferradini, L, Fogg, C, Grandesso, F, Guthmann, J P, Kigozi, I, Kiguli, J, Kyomuhendo, J, Piola, P, Ruzagira, E, Taylor, W R J   +13 more
core   +3 more sources

Comparative Assessment of Adverse Effects of Synergistic Combination of Pyrimethamine and Sulfadoxine (Fansidar/Maloxine) in Patients Studied in Abakaliki, Ebonyi State, Nigeria

, 2021
I. M. Ikeh, O.O. Odikamnoro, V. O. Okonkwo, I. O. Nnatuanya   +3 more
openalex   +1 more source

Antiparasitic Effects of Heracleum persicum and Foeniculum vulgare (Fruit) Essential Oils on Experimental Toxoplasmosis (In Vitro and In Vivo)

Journal of Mazandaran University of Medical Sciences, 2021
Background and purpose: There are few treatment options available for treatment of toxoplasmosis and effective drugs have serious toxic effects. In this study, the in vivo and in vitro anti-toxoplasma activities of Heracleum persicum and Foeniculum ...
Mahbobeh Montazeri, Samira Khani, Ahmad Daryani, Shahabeddin Sarvi, Somayeh Shahani, Fatemeh Mirzaee, Somaye Yosefi, Shirzad Gholami   +7 more
doaj