Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5'-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives. [PDF]
Purinergic Signal, 2021 Scaletti E +4 more
europepmc +1 more source
Sequence-specific Solution Structures of the Four Isosequential Pairs of Single-stranded DNAs and RNAs [PDF]
, 2008 The role of the sequence-context in the self-organization of four single-stranded (ss) isosequential pairs of DNAs (1 – 4) and RNAs (5 – 8), [d/r-(5'C^1^A^2^X^3^G^4^Y^5^A^6^C^7^): X^3^ = A or C, Y^5^ = A or C; sequence variations: 2^2^
Jyoti Chattopadhyaya +2 more
core +1 more source
Non-canonical role of UCKL1 on ferroptosis defence in colorectal cancerResearch in context
EBioMedicine, 2023 Summary: Background: Pyrimidine nucleotides fuel the growth of colorectal cancer (CRC), making their associated proteins potential targets for cancer intervention.
Weili Wu +10 more
doaj
Skeletal Muscle Memory: An Update From the Antidoping Perspective
Drug Testing and Analysis, EarlyView.ABSTRACT This narrative review explores the concept of muscle memory, focusing on the physiological and biochemical mechanisms underlying information retention in skeletal muscle tissue as it relates to antidoping. The discussion encompasses the role of satellite cells (SCs) in myonuclei recruitment, resulting in increased myonuclear density and ...
Claire Traversa
wiley +1 more source
Structure-activity relationships of pyrimidine nucleotides containing a 5'-α,β-methylene diphosphonate at the P2Y6 receptor. [PDF]
Bioorg Med Chem Lett, 2021 Oliva P +8 more
europepmc +1 more source
The reactions of mercurated pyrimidine nucleotides with thiols and with hydrogen sulfide
Nucleic Acids Research, 1978 In the presence of thiols, 5-mercuripyrimidine nucleotides are quantitatively converted to 5-thiomercuri derivatives, but these compounds are unstable and decompose at a rate dependent on the nature of the thiol. The decomposition involves three different reactions and proceeds via a symmetrical mercury derivative of the nucleotide.
Van Broeckhoven, Christine +1 more
openaire +5 more sources
A Comparative Experimental and Theoretical Study on Doubly Differential Electron-Impact Ionization Cross Sections of Pyrimidine [PDF]
To provide a comprehensive data set for track structure-based simulations of radiation damage in DNA, doubly differential electron-impact ionization cross sections of pyrimidine, a building block of the nucleobases cytosine and thymine, were measured for primary electron energies between 30 eV and 1 keV as a function of emission angle and secondary ...
arxiv +1 more source
Metabolic changes during cardiac regeneration in the axolotl
Developmental Dynamics, EarlyView.Abstract Background The axolotl is a prominent model organism of heart regeneration due to its ability to anatomically and functionally repair the heart after an injury that mimics human myocardial infarction. In humans, such an injury leads to permanent scarring. Cardiac regeneration has been linked to metabolism and the oxygenation state, but so far,
Anita Dittrich +10 more
wiley +1 more source
Role of a "Magic" Methyl: 2'-Deoxy-2'-α-F-2'-β-C-methyl Pyrimidine Nucleotides Modulate RNA Interference Activity through Synergy with 5'-Phosphate Mimics and Mitigation of Off-Target Effects. [PDF]
J Am Chem Soc, 2022 Guenther DC +14 more
europepmc +1 more source
Liapunov exponent distributions and maps for multiple parameter logistic equation. Application to DNA and RNA sequences [PDF]
arXivThe multiple parameter logistic equation has previously been utilized to determine the global stability of ternary codes, based on the arrangement of different symbols within the code. This approach has been extended to DNA and RNA sequences, proposing a specific application in the context of reading and translation processes involved in DNA ...
arxiv