Results 121 to 130 of about 48,430 (295)
Versatile Palladium‐Catalyzed C‐H Arylation of Fluoroarenes with 2‐Chloropyridine Derivatives
Chemistry – A European Journal, EarlyView.Direct C─H arylation of fluoroarenes with 2‐chloropyridines is enabled by a simple Pd/SPhos system in isopropyl acetate. The method uses inexpensive reactants and shows broad scope and high yields. DFT computations explain reactivity and selectivity.
Federico Belnome +6 more
wiley +1 more source
Catabolism of Pyrimidines in Yeast
, 2014 Pyrimidines are important precursors for nucleic acids, and constantly synthesized and degraded in the cell to maintain a balanced supply. Many microoganisms can also extract the nitrogens from the pyrimidine ring, and use them as a nitrogen source when “
Rasmussen, Anna
core
, 2019 To evade the possible toxicity associated with the formation of quinone-imine metabolite in amodiaquine (AQ), the para-hydroxyl group was replaced with a −F atom, and the resulting 4′-fluoro-amodiaquine (FAQ) was hybridized with substituted pyrimidines ...
Babu L. Tekwani +15 more
core +1 more source
Chemistry – A European Journal, EarlyView.5‐Substituted 2‐(naphthalen‐2‐yl)‐4H‐chromen‐4‐ones are reported as a novel class of highly potent and selective triplex DNA ligands. These ligands induce triplex formation at submicromolar concentrations and inhibit enzymatic activity via ligand‐mediated triplex formation.
Nghia Tran +4 more
wiley +1 more source
Chemistry – A European Journal, EarlyView.ABSTRACT Fluorouracil‐platinum(IV) prodrugs represent a novel class of multimechanistic chemotherapeutics with enhanced anticancer potential. The prodrugs PtIVP‐5FUMeOBut and PtIV56‐5FUMeOBut were actualized by derivatising the clinical drug 5‐fluorouracil (5FU) and coordinating it to platinum(IV) complexes, leveraging the established cytotoxicity of ...
Maria George Elias +9 more
wiley +1 more source
Pyrido [4, 3 - d] Pyrimidines [PDF]
The methods available for the synthesis of tetrahydro-, octahydro- and fully aromatic pyrido[4, 3-d]pyrimidines are reviewed. Three new routes for the syntheses of pyridol 4, 3-d]pyrimidines are described.
Ismail, Abbasali Gulamhusein
core
Design, Synthesis and Binding Studies of Trisubstitutedpyrazolo[3,4-d]pyrimidines
, 2006 Pyrazolo[3,4-d]pyrimidines were known as adenosine antagonists at the rat A1 and A2A adenosine receptors based on our previous studies. In this study, 245 pyrazolo[3,4-d]pyrimidines derivatives with various benzyl substitutents at N-1 and various ...
Do, Khoa Quang
core +1 more source
Chemistry – A European Journal, EarlyView.A readily accessible, air‐ and moisture‐stable palladium precatalyst, [Pd(1‐MeNAP)(tBuBrettPhos)]OTf, enables the direct N‐arylation of NH‐sulfoximines with (hetero)aryl chlorides under exceptionally mild conditions ideal for late‐stage diversification of drug‐like scaffolds.
Sourav Manna +5 more
wiley +1 more source
Chemistry – A European Journal, EarlyView.Using kanamycin A as a model target, we developed click‐capture SELEX to identify nucleobase‐modified aptamers capable of binding small molecules in solution. This approach enables flexible incorporation of nucleobase modifications via CuAAC, allowing the chemical properties of the aptamer to be tailored to the target molecule.
Philipp Menke +5 more
wiley +1 more source
, 2016 Methods have been devised to generate 1H-1,3-diaza-1,3-butadienes bearing a leaving group at position-4 in latent, masked, and unprotected forms. A hallmark of these azadienes is that they undergo thermal [4π + 2π] cycloaddition reactions with electron ...
Francisco X. Talamás (3036813) +5 more
core +1 more source