Results 101 to 110 of about 48,430 (295)

Syntheses and reactions of thieno [2,3-d] pyrimidines [PDF]

Thieno [2,3-d] pyrimidines have, so far, been synthesised mainly from thiophen derivatives. The work described in this thesis is largely concerned with a search for general methods of synthesising substituted thieno [2,3-d] pyrimidines from ...
Shahhet, MS
core  

A Ruthenium‐(Ph‐BPE) Catalyst for Asymmetric Alkynylation of Fluoral: Enantioselection From 1 of 12 Fluxional Stereogenic‐at‐Ruthenium Complexes

Angewandte Chemie International Edition, EarlyView.
The first enantioselective alkynylations of aqueous fluoral are described. These processes are catalyzed by an iodide‐bound ruthenium‐(Ph‐BPE)‐catalyst; an octahedral metal complex that can exist as 12 diastereomeric‐at‐metal isomers. Calculations reveal that 2 of 12 stereoisomeric complexes account for 99.9% of the Boltzmann population and that ...
Weijia Shen, Sebastian Höthker, Colin E. Hayter, Nicholas K. Bowers, Andrea Pellegrini, Stefan Grimme, Michael J. Krische   +6 more
wiley   +1 more source

Modular synthesis of the pyrimidine core of the manzacidins by divergent Tsuji–Trost coupling

Beilstein Journal of Organic Chemistry, 2016
The design, development and application of an efficient procedure for the concise synthesis of the 1,3-syn- and anti-tetrahydropyrimidine cores of manzacidins are reported.
Sebastian Bretzke, Stephan Scheeff, Felicitas Vollmeyer, Friederike Eberhagen, Frank Rominger, Dirk Menche   +5 more
doaj   +1 more source

Inosine‐Triphosphate‐Pyrophosphatase Activity as a Potential Predictor of Methotrexate Remission in Juvenile Idiopathic Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Methotrexate (MTX) is the first‐line therapy for juvenile idiopathic arthritis (JIA), but up to 40% of patients do not respond to it. Low inosine triphosphate pyrophosphatase (ITPA) activity has been associated with reduced clinical remission. We investigated the role and underlying mechanisms of ITPA in vitro. Methods ITPA enzymatic activity
Sofia Sindici Forgiarini, Marianna Lucafò, Debora Curci, Davide Selvestrel, Valentina Moressa, Sofia Pagarin, Barbara Bellich, Martina Franzin, Alberto Tommasini, Mara L. Becker, Laura B. Ramsey, Susan D. Thompson, Carl D. Langefeld, Federica Corba, Edoardo Marrani, Gabriele Simonini, Gabriele Stocco, Giuliana Decorti, Andrea Taddio, Serena Pastore   +19 more
wiley   +1 more source

Tissue‐Specific and Spatially Dependent Metabolic Signatures Perturbed by Injury in Male and Female Mice

Arthritis &Rheumatology, EarlyView.
Objective Osteoarthritis, the leading cause of disability worldwide, disproportionately affects women, yet sex remains an overlooked determinant. This disparity stems from sex‐specific differences in injury susceptibility—a major risk factor for disease.
Hope D. Welhaven, Avery H. Welfley, Priyanka P. Brahmachary, Mark Greenwood, Donald F. Smith, Brian Bothner, Ronald K. June   +6 more
wiley   +1 more source

A Modular Nucleoside Kinase Cascade for the Synthesis of Ribonucleoside Triphosphates

Biotechnology and Bioengineering, EarlyView.
Damm et al. report standardized enzymatic cascades for production of all canonical nucleoside triphosphates from the corresponding nucleosides, using kinase‐catalyzed phosphorylation from acetyl phosphate. Reactions afforded ∼ 100 mM product in near‐quantitative conversion.
Oliver T. Damm, Martin Pfeiffer, Johannes Zöhrer, Bernd Nidetzky   +3 more
wiley   +1 more source

Synthesis of some 2,4-diamino-pyrrolo-pyrimidines

, 1978
Some new 2, 4-diamino-pyrrolo-pyrimidines have been synthesized.
Merchant, J. R., Dike, Suneel Y.
core   +1 more source

Exploration of structure–activity relationship of 2,4‐diaminopyrimidine derivatives as hematopoietic progenitor kinase 1 inhibitors

Bulletin of the Korean Chemical Society, EarlyView.
Targeting HPK1 is a promising strategy to restore T‐cell anti‐tumor immunity. We report the design and synthesis of novel 2,4‐diaminopyrimidine derivatives, focusing on systematic structure–activity relationship (SAR) analysis These findings identify key structural features for potent HPK1 inhibition, facilitating the discovery of next‐generation ...
Heechan Shin, Mi‐Ran Byun, Joon Seok Choi, Sujin Lee   +3 more
wiley   +1 more source

Pyrrolo[2,3-d]pyrimidines : design, synthesis, functionalisation

, 2015
Les pyrrolo[2,3-d]pyrimidines, également connues sous le nom de 7-déazapurines, sont une classe importante d’hétérocycliques aromatiques, de par leurs potentiels biologiques (antitumoral, antiinflammatoire, antibactérien, etc.).
Prieur, Vanessa
core  

Solid-phase synthesis of tetrasubstituted pyrrolo[2,3-d]pyrimidines

, 2018
A facile solid phase synthesis of 2,4,6,7-tetrasubstituted pyrrolo[2,3-d]pyrimidines is described. The synthesis involves a highly efficient five-step route starting from resin-bound dimeric peptoids.
Lim, HS, Lee, JH
core   +1 more source