Catabolism of Pyrimidines in Yeast [PDF]
, 2014 Pyrimidines are important precursors for nucleic acids, and constantly synthesized and degraded in the cell to maintain a balanced supply. Many microoganisms can also extract the nitrogens from the pyrimidine ring, and use them as a nitrogen source when “
Rasmussen, Anna
core
Hybridization of Fluoro-amodiaquine (FAQ) with Pyrimidines: Synthesis and Antimalarial Efficacy of FAQ–Pyrimidines [PDF]
, 2019 To evade the possible toxicity associated with the formation of quinone-imine metabolite in amodiaquine (AQ), the para-hydroxyl group was replaced with a −F atom, and the resulting 4′-fluoro-amodiaquine (FAQ) was hybridized with substituted pyrimidines ...
Babu L. Tekwani +15 more
core +1 more source
Photochemisch erzeugte Oxetane als Schlüssel zur endergonen Cyclopropansynthese
Angewandte Chemie, EarlyView.Eine neuartige Oxetan‐zu‐Cyclopropan‐Umlagerung eröffnet einen atomökonomischen Zugang zu dicht funktionalisierten Cyclopropanen aus Furanen und photochemisch aktivierten Aldehyden. Die erhaltenen Strukturen erschließen komplexe bioaktive Motive und fungieren als vielseitige Plattform für die asymmetrische Cyclopropansynthese.
Tim Köglmeier +2 more
wiley +1 more source
Molecules, 2013 Ten 1,4-disubstituted 1,2,3-triazoles were synthesized from one of 1-(azido-methyl)benzene, 1-(azidomethyl)-4-fluorobenzene, 1-(azidomethyl)-4-chlorobenzene, 1-(azidomethyl)-4-bromobenzene or 1-(azidomethyl)-4-iodobenzene, generated in situ from sodium ...
Mario A. Romero-Romo +7 more
doaj +1 more source
Design, Synthesis and Binding Studies of Trisubstitutedpyrazolo[3,4-d]pyrimidines [PDF]
, 2006 Pyrazolo[3,4-d]pyrimidines were known as adenosine antagonists at the rat A1 and A2A adenosine receptors based on our previous studies. In this study, 245 pyrazolo[3,4-d]pyrimidines derivatives with various benzyl substitutents at N-1 and various ...
Do, Khoa Quang
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Syntheses and reactions of thieno [2,3-d] pyrimidines [PDF]
Thieno [2,3-d] pyrimidines have, so far, been synthesised mainly from thiophen derivatives. The work described in this thesis is largely concerned with a search for general methods of synthesising substituted thieno [2,3-d] pyrimidines from ...
Shahhet, MS
core
1,3-Diaza-1,3-butadienes. Synthesis and Conversion into Pyrimidines by [4π + 2π] Cycloaddition with Electron Deficient Acetylenes. Synthetic Utility of 2-(Trichloromethyl)pyrimidines1 [PDF]
, 2016 Methods have been devised to generate 1H-1,3-diaza-1,3-butadienes bearing a leaving group at position-4 in latent, masked, and unprotected forms. A hallmark of these azadienes is that they undergo thermal [4π + 2π] cycloaddition reactions with electron ...
Francisco X. Talamás (3036813) +5 more
core +1 more source
Photogenerated Oxetanes as a Gateway to Uphill Cyclopropanation
Angewandte Chemie International Edition, EarlyView.An atom‐economical route to densely functionalized cyclopropanes from furans and photochemically activated aldehydes is enabled by a unique oxetane‐to‐cyclopropane rearrangement. These cyclopropanes can be used to access complex bioactive scaffolds and serve as a platform for asymmetric cyclopropane synthesis.
Tim Köglmeier +2 more
wiley +1 more source
Synthesis of Bicyclic Pyrrolo[2,3-d]Pyrimidines, and Tricyclic Indeno[2,1-d]/[1,2-d]Pyrimidines as Receptor Tyrosine Kinase (RTK) Inhibitors and Antimitotic Agents [PDF]
, 2010 The dissertation will give an introduction, background and our research progress in the areas of receptor tyrosine kinases inhibitors and antimitosis inhibitors. The design and syntheses of bicyclic pyrrolo[2,3-d]pyrimidines, and tricyclic indeno[2,1-d]-
Zhao, Ying
core +1 more source
Substrate identification of putative NCS1 and NCS2 nucleobase transporters in Pseudomonas aeruginosa
mBioPseudomonas aeruginosa is an opportunistic pathogen that can salvage nucleobases from the environment to conserve nutrients that would otherwise be spent on de novo nucleotide biosynthesis.
Corey Kennelly, Arthur Prindle
doaj +1 more source