Results 91 to 100 of about 11,360 (191)

Heterocyclic steroids: Efficient routes for annulation of pentacyclic steroidal pyrimidines

, 2020
Steroids are components of cell membranes, signaling molecules and are a type of secondary metabolites as a result of their high impact of biological significance.
Abdel-Latif, Doaa, Monier, M., El-Mekabaty, Ahmed, Elattar, Khaled M., Mert, Baak Dogru   +4 more
core   +1 more source

Basophilic Stippling Unmasks Pyrimidine 5′‐Nucleotidase Deficiency in a G6PD‐Deficient Patient

American Journal of Hematology, EarlyView.
Victor Bobée, Stéphane Moutereau, Maïssa Souissi, Pierre Lebreton, Loïc Garcon   +4 more
wiley   +1 more source

SYNTHESIS OF 4,4'-BIS-PYRIMIDINES AND SOME RELATED BIS-FUSED PYRIMIDINES [PDF]

, 1995
2,2'-Disubstitutedamino-4-4'-bis-pyrimidines (3a-m) have been prepared by linking 2,4-dichloro-6-methyl-5-nitropyrimidine (1) with several diamines and subsequent reaction with suitable amines.

core  

Thinking Outside the Binding Site: A Self‐Encapsulating Kinase Inhibitor Remodels Its Pocket to Achieve Selectivity

Angewandte Chemie International Edition, EarlyView.
To make exceptionally effective drugs, thinking “outside the binding site” is required. This work reveals that counterintuitive targeting of a kinase‐conserved region can lead to highly selective binding. Inhibitor discovery coupled to x‐ray crystallography shows that a network of noncanonical interactions and long‐range effects of distant unique amino
Nico J. Seidler, Monica R. MacDonald, Athina A. Moschopoulou, Sahba Cunningham, Tess M. Weber, Nader N. Nasief, Lorenz Mayer, Frederik W. Hacker, Ekaterina Hermann, Mareike B. Möllers, Yuliia Skliarenko, Tahereh Damghani, Abid N. Manzar, Kaly S. Lin, Ramona Rudalska, Marcia I. Goettert, Lars Zender, Daniel Dauch, Michael Forster, Stefan A. Laufer, David E. Heppner   +20 more
wiley   +1 more source

Substrate identification of putative NCS1 and NCS2 nucleobase transporters in Pseudomonas aeruginosa

mBio
Pseudomonas aeruginosa is an opportunistic pathogen that can salvage nucleobases from the environment to conserve nutrients that would otherwise be spent on de novo nucleotide biosynthesis.
Corey Kennelly, Arthur Prindle
doaj   +1 more source

Syntheses and reactions of thieno [2,3-d] pyrimidines [PDF]

Thieno [2,3-d] pyrimidines have, so far, been synthesised mainly from thiophen derivatives. The work described in this thesis is largely concerned with a search for general methods of synthesising substituted thieno [2,3-d] pyrimidines from ...
Shahhet, MS
core   +1 more source

Purine and pyrimidine synthesis differently affect the strength of the inoculum effect for aminoglycoside and β-lactam antibiotics

Microbiology Spectrum
The inoculum effect has been observed for nearly all antibiotics and bacterial species. However, explanations accounting for its occurrence and strength are lacking.
Daniella M. Hernandez, Melissa Marzouk, Madeline Cole, Marla C. Fortoul, Saipranavi Reddy Kethireddy, Rehan Contractor, Habibul Islam, Trent Moulder, Ariane R. Kalifa, Estefania Marin Meneses, Maximiliano Barbosa Mendoza, Ruth Thomas, Saad Masud, Sheena Pubien, Patricia Milanes, Gabriela Diaz-Tang, Allison J. Lopatkin, Robert P. Smith   +17 more
doaj   +1 more source

Preparation of 4,5-Disubstituted Pyrimidines:  Ring Substitution of 5-Mesyloxymethylpyrimidines

, 2016
Preparation of 4,5-Disubstituted Pyrimidines:  Ring Substitution of 5 ...
Anu Mahadevan (2655325), Mario D. Gonzalez (3010740), John McKew (2319478), Howard Sard (2655322)   +3 more
core   +1 more source

Synthesis of pyrido[1,2-[alpha symbol] ]pyrimidine scaffolds and their DNA-binding studies

, 2014
Access to thesis permanently restricted to Ball State community only.Access to abstract permanently restricted to Ball State community only.Thesis (M.S.)Department of ChemistryIntroduction to pyrido[1,2- [alpha symbol] ]pyrimidines and their synthesis ...
Habarakada Liyanage, Thakshila Udayakanthi Liyanage
core  

Induction and Enhancement of Bacteriocin Production (Review)

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Conventionally, bacteriocins are produced by microorganisms on complex substrates, released as semi‐purified preparations or crude fermentates. These bacteriocin‐containing products often exhibit unsatisfactory purity, low active‐substance content, and high production costs, limiting their commercialization and use. This review aims to analyze
Oksana Knysh, Artur Martynov
wiley   +1 more source