Results 81 to 90 of about 11,360 (191)

Efficient synthesis and preliminary biological evaluations of trifluoromethylated imidazo[1,2- a ]pyrimidines and benzimidazo[1,2- a ]pyrimidines

, 2019
International audienceFluoromethylated imidazo[1,2-a]pyrimidines and benzimidazo[1,2-a]pyrimidines were synthesized through Michael addition/intramolecular cyclization reaction by condensation of 2-amino imidazole derivatives with ethyl 4,4,4 ...
Akssira, Mohamed, Jismy, Badr, Guillaumet, Gérald, Knez, Damijan, Gobec, Stanislav, Abarbri, Mohamed   +5 more
core   +1 more source

Proteomic Profiling of Nodal T‐Follicular Helper Cell Lymphoma Reveals Distinct Biological Signatures and Improves Prognostic Stratification Beyond the IPI

American Journal of Hematology, EarlyView.
ABSTRACT Nodal T‐follicular helper cell lymphoma (nTFHL), most commonly of angioimmunoblastic type, exhibits heterogeneous clinical outcomes that are not fully explained by current clinical and biological variables. While genetic alterations have been extensively investigated, its proteomic landscape remains largely unexplored.
David Beauvais, Yanis Zirem, Tristan Cardon, Soulaimane Aboulouard, Romain Dubois, Isabelle Fournier, Franck Morschhauser, Michel Salzet, Ibrahim Yakoub‐Agha, Marie Duhamel   +9 more
wiley   +1 more source

Modification of Purine and Pyrimidine Nucleosides by Direct C-H Bond Activation

Molecules, 2015
Transition metal-catalyzed modifications of the activated heterocyclic bases of nucleosides as well as DNA or RNA fragments employing traditional cross-coupling methods have been well-established in nucleic acid chemistry.
Yong Liang, Stanislaw F. Wnuk
doaj   +1 more source

Pyrimidines- and purines-rich sequences of miRNAs.

, 2016
The table shows the content of the pyrimidines or purines nucleotides according to the sequence of miRNAs. The total contents of purines or pyrimidines of the miRNAs presented in the table is above 90%.
Jan Barciszewski (55070), Dariusz Wawrzyniak (2587537), Agnieszka Belter (665923), Monika Piwecka (665925), Miroslawa Z. Barciszewska (2587531), Katarzyna Rolle (95323), Jaroslaw Jeleniewicz (2587534)   +6 more
core   +1 more source

Über die Bindungsstelle hinausgedacht: Ein sich selbsteinkapselnder Kinase‐Inhibitor modelliert seine Bindetasche und erzielt so Selektivität

Angewandte Chemie, EarlyView.
Um außergewöhnlich wirksame Wirkstoffe zu entwickeln, ist es erforderlich, über die Bindungsstelle hinaus zu denken. Diese Arbeit zeigt, dass die auf den ersten Blick kontraintuitive Adressierung einer konservierten Region der Kinase zu einer hochselektiven Bindung führen kann.
Nico J. Seidler, Monica R. MacDonald, Athina A. Moschopoulou, Sahba Cunningham, Tess M. Weber, Nader N. Nasief, Lorenz Mayer, Frederik W. Hacker, Ekaterina Hermann, Mareike B. Möllers, Yuliia Skliarenko, Tahereh Damghani, Abid N. Manzar, Kaly S. Lin, Ramona Rudalska, Marcia I. Goettert, Lars Zender, Daniel Dauch, Michael Forster, Stefan A. Laufer, David E. Heppner   +20 more
wiley   +1 more source

Synthesis of Bicyclic Pyrrolo[2,3-d]Pyrimidines, and Tricyclic Indeno[2,1-d]/[1,2-d]Pyrimidines as Receptor Tyrosine Kinase (RTK) Inhibitors and Antimitotic Agents [PDF]

, 2010
The dissertation will give an introduction, background and our research progress in the areas of receptor tyrosine kinases inhibitors and antimitosis inhibitors. The design and syntheses of bicyclic pyrrolo[2,3-d]pyrimidines, and tricyclic indeno[2,1-d]-
Zhao, Ying
core  

Solid-phase synthesis of tetrasubstituted pyrrolo[2,3-d]pyrimidines

, 2018
A facile solid phase synthesis of 2,4,6,7-tetrasubstituted pyrrolo[2,3-d]pyrimidines is described. The synthesis involves a highly efficient five-step route starting from resin-bound dimeric peptoids.
Lim, HS, Lee, JH
core   +1 more source

Synthesis of New 1,2,3-Triazole Derivatives of Uracil and Thymine with Potential Inhibitory Activity against Acidic Corrosion of Steels

Molecules, 2013
Ten 1,4-disubstituted 1,2,3-triazoles were synthesized from one of 1-(azido-methyl)benzene, 1-(azidomethyl)-4-fluorobenzene, 1-(azidomethyl)-4-chlorobenzene, 1-(azidomethyl)-4-bromobenzene or 1-(azidomethyl)-4-iodobenzene, generated in situ from sodium ...
Mario A. Romero-Romo, Manuel E. Palomar-Pardavé, Nidia Maldonado-Carmona, Araceli Espinoza-Vázquez, Deyanira Angeles-Beltrán, Rodrigo González-Olvera, Guillermo E. Negrón-Silva, Rosa Santillan   +7 more
doaj   +1 more source

PHOTOELECTRON STUDIES OF THE VALENCE ELECTRONIC STRUCTURE OF BIOLOGICAL PYRIMIDINES.

, 1977
PHOTOELECTRON STUDIES OF THE VALENCE ELECTRONIC STRUCTURE OF BIOLOGICAL ...
ALEXANDER. PADVA (7983530)
core   +3 more sources

PHOTOELECTRON STUDIES AND ELECTRONIC INFLUENCES OF BIOLOGICAL PURINES AND PYRIMIDINES.

, 1980
PHOTOELECTRON STUDIES AND ELECTRONIC INFLUENCES OF BIOLOGICAL PURINES AND ...
JUNG-HUI. LIN (7979771)
core   +3 more sources