Results 61 to 70 of about 48,430 (295)

Novel Nanomolar Allosteric Modulators of AMPA Receptor of Bis(pyrimidine) Series: Synthesis, Biotesting and SAR Analysis

Molecules, 2022
Positive allosteric modulators (PAMs) of AMPA receptors represent attractive candidates for the development of drugs for the treatment of cognitive and neurodegenerative disorders.
Kseniya N. Sedenkova, Denis V. Zverev, Anna A. Nazarova, Mstislav I. Lavrov, Eugene V. Radchenko, Yuri K. Grishin, Alexey V. Gabrel’yan, Vladimir L. Zamoyski, Vladimir V. Grigoriev, Elena B. Averina, Vladimir A. Palyulin   +10 more
doaj   +1 more source

Discovery of a Potent Fluorescence Polarization Probe for Identifying USP1 Allosteric Inhibitors

Advanced Science, EarlyView.
This study presents the first ubiquitin‐specific protease 1 (USP1) allosteric fluoroprobe and fluorescence polarization assay, enabling the differentiation of allosteric and catalytic site inhibitors. Further, a novel class of tetrahydroisoquinoline‐based USP1 inhibitors is designed, with compound 14a (USP1 IC50 = 29.9 nM) showing strong selectivity ...
Jiawei Cheng, Peipei Wang, Pengfei Wang, Jiamin Wang, Baiyang Li, Daqing Fang, Jian He, Xiaobei Hu, Weijuan Kan, Yubo Zhou, Chunpu Li, Jia Li, Hong Liu   +12 more
wiley   +1 more source

Synthesis and Antioxidant Activities of Novel Pyrimidine Acrylamides as Inhibitors of Lipoxygenase: Molecular Modeling and In Silico Physicochemical Studies

Molecules
The pyrimidine ring is present in various biomolecules such as DNA and RNA bases, aminoacids, vitamins, etc. Additionally, many clinically used drugs including methotrexate and risperidone contain the pyrimidine heterocyclic scaffold as well.
Michail Saragatsis, Eleni Pontiki
doaj   +1 more source

Catalytic Synthesis of Luminescent Pyrimidines via Acceptor-less Dehydrogenative Coupling

, 2021
A simple catalytic synthesis of luminescent pyrimidines from benzamidines and alcohols is reported. These one-pot, acceptor-less dehydrogenative coupling reactions are catalyzed by a ruthenium hydrido chloride complex (1), supported by a chelating P^N ...
Herbert, David E, Stotska, Olha, Mondal, Rajarshi, Lozada, Issiah   +3 more
core   +1 more source

Localizable Fluorescent Metal Ion Indicators With Tunable Colors

Advanced Science, EarlyView.
A modular platform enables the generation of fluorescent metal ion indicators with tunable emission colors and precise subcellular localization. Conjugation to self‐labeling proteins yields bright, color‐tunable potassium probes that permit wash‐free live‐cell imaging, revealing dynamic potassium efflux in stimulated neurons.
Ming‐Ming Wang, De‐en Sun, Klara Gries, Kai Johnsson   +3 more
wiley   +1 more source

Pyrimidines- and purines-rich sequences of miRNAs.

, 2016
The table shows the content of the pyrimidines or purines nucleotides according to the sequence of miRNAs. The total contents of purines or pyrimidines of the miRNAs presented in the table is above 90%.
Jan Barciszewski (55070), Dariusz Wawrzyniak (2587537), Agnieszka Belter (665923), Monika Piwecka (665925), Miroslawa Z. Barciszewska (2587531), Katarzyna Rolle (95323), Jaroslaw Jeleniewicz (2587534)   +6 more
core   +1 more source

Light‐Switched Mesenchymal Stem Cells for In Situ Exosome Amplification in Craniofacial Bone Defect Reconstruction

Advanced Science, EarlyView.
Light‐switchable MSCs (MSC‐UCNPs) were constructed by intracellular incorporation of UCNPs. Upon 980 nm irradiation, UCNPs emitted localized ultraviolet light (365 nm), activating the ROS/HEXB/LAMP1 signaling pathway to suppress lysosome–multivesicular body fusion and thereby enhance exosome biogenesis. Embedded within an injectable hydrogel, MSC‐UCNPs
Tingting Wu, Yajing Liu, Shuman Wang, Xiaoming Bai, Luyun Zhang, Yuwei Liu, Zhiwen Fu, Chen Shi   +7 more
wiley   +1 more source

Coordination‐Driven Direct C─H Metalation of N‐Heterocycles With a Superbasic Co(II) Amide Co(TMP)2

Angewandte Chemie, EarlyView.
By enabling regioselectivities that are inaccessible with conventional bases, this study introduces a Co(II) amide platform for the deprotonative C─H metalation of sensitive N‐heterocycles. Subsequent interception of the resulting Co(II) intermediates with external oxidants affords a family of sterically congested, TMP‐substituted heterocycles via C─N ...
Na Jin, Manting Mu, Max García‐Melchor, Eva Hevia   +3 more
wiley   +2 more sources

Palladium-Catalyzed Intramolecular Cross-Dehydrogenative Coupling: Synthesis of Fused Imidazo[1,2‑a]pyrimidines and Pyrazolo[1,5‑a]pyrimidines

, 2017
A palladium-catalyzed intramolecular dehydrogenative coupling reaction was developed for the synthesis of fused imidazo­[1,2-a]­pyrimidines and pyrazolo­[1,5-a]­pyrimidines.
Siva K. Reddy Kotla (2032867), Jeh-Jeng Wang (1633303), Jaya Kishore Vandavasi (1633306), Rakesh K. Tiwari (1337817), Keykavous Parang (281303)   +4 more
core   +2 more sources

Palladium-Catalyzed Intramolecular Cross-Dehydrogenative Coupling: Synthesis of Fused Imidazo[1,2‑a]pyrimidines and Pyrazolo[1,5‑a]pyrimidines

, 2017
A palladium-catalyzed intramolecular dehydrogenative coupling reaction was developed for the synthesis of fused imidazo[1,2-a]pyrimidines and pyrazolo[1,5-a]- pyrimidines.
Wang, Jeh-Jeh, Keykavous Parang, Jaya Kishore Vandavasi, Siva K. Reddy Kotla, Rakesh K. Tiwari, Kotla, Siva K. Reddy, Vandavasi, Jaya Kishore, Parang, Keykavous, Jeh-Jeng Wang, Tiwari, Rakesh   +9 more
core   +1 more source