Results 41 to 50 of about 48,617 (303)
, 2015 The reaction of 3(5)-amino-5(3)-hydrazinopyrazole, a bifunctional compound, with 3-oxo-3-phenylpropanenitrile and two of its p-substituted derivatives affords 2,5-diaryl-7-aminopyrazolo[1,5-a]pyrimidines.
Claramunt, R.M. +15 more
core +1 more source
Synthesis of pyrimidines using nano-NiZr4 (PO4)6 as a retrievable and robust heterogeneous catalyst [PDF]
Nanochemistry Research, 2020 Nano-NiZr4 (PO4)6 has been used as an effective and retrievable heterogeneous catalyst for the synthesis of pyrimidines through the reaction of benzaldehydes, guanidinehydrochloride and malononitrile under reflux conditions in ethanol.
Hossein Shahbazi-Alavi +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Efficient synthesis and preliminary biological evaluations of trifluoromethylated imidazo[1,2- a ]pyrimidines and benzimidazo[1,2- a ]pyrimidines [PDF]
, 2019 International audienceFluoromethylated imidazo[1,2-a]pyrimidines and benzimidazo[1,2-a]pyrimidines were synthesized through Michael addition/intramolecular cyclization reaction by condensation of 2-amino imidazole derivatives with ethyl 4,4,4 ...
Akssira, Mohamed +5 more
core +1 more source
MoleculesCancer is a leading cause of death globally, claiming millions of lives each year. Despite the availability of numerous anticancer drugs, the need for new treatment options remains essential. Many current therapies come with significant toxicity, lead to
Simona Iacob (Ciobotaru) +9 more
doaj +1 more source
Computational Estimation of the Acidities of Pyrimidines and Related Compounds
Molecules, 2022 Pyrimidines are key components in the genetic code of living organisms and the pyrimidine scaffold is also found in many bioactive and medicinal compounds. The acidities of these compounds, as represented by their pKas, are of special interest since they
Rachael A. Holt, Paul G. Seybold
doaj +1 more source
FEBS Open Bio, EarlyView.The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong +3 more
wiley +1 more source
Heterocyclic steroids: Efficient routes for annulation of pentacyclic steroidal pyrimidines [PDF]
, 2020 Steroids are components of cell membranes, signaling molecules and are a type of secondary metabolites as a result of their high impact of biological significance.
Abdel-Latif, Doaa +4 more
core +1 more source
Design and Synthesis of New Pyrimidine-Quinolone Hybrids as Novel hLDHA Inhibitors
Pharmaceuticals, 2022 A battery of novel pyrimidine-quinolone hybrids was designed by docking scaffold replacement as lactate dehydrogenase A (hLDHA) inhibitors. Structures with different linkers between the pyrimidine and quinolone scaffolds (10-21 and 24–31) were studied in
Iván Díaz +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta +7 more
wiley +1 more source