Results 31 to 40 of about 52,181 (281)

Preparation and Diagnosis of Pyrimidines Derivatives by Conventional And Microwave Ways. [PDF]

مجلة جامعة الانبار للعلوم الصرفة, 2017
This work includes synthesis and characterization of new derivatives of pyrimidine (R. or Ar. -1, 2, 3, 4-tetrahydropyrimidin-5-yl) ethan-1-one), via the reaction of acetyl acetone with different aldehydes and guanidine hydrochloride.
Waleed F. AL-Hiti, Samea J. Khammase, Bushra T. Mahdi   +2 more
doaj   +1 more source

Synthesis of Pyrimidines and Condensed Pyrimidines [PDF]

Bulletin of the Chemical Society of Japan, 1973
Abstract A new one-step synthesis of pyrimidines and condensed pyrimidines by heating carboxamides or cyclic lactams with formamide in the presence of POCl3 in a sealed tube is described.
openaire   +1 more source

Pyrido [4, 3 - d] Pyrimidines [PDF]

The methods available for the synthesis of tetrahydro-, octahydro- and fully aromatic pyrido[4, 3-d]pyrimidines are reviewed. Three new routes for the syntheses of pyridol 4, 3-d]pyrimidines are described.
Ismail, Abbasali Gulamhusein
core   +8 more sources

The Dynamic Influence of Olorofim (F901318) on the Cell Morphology and Organization of Living Cells of Aspergillus fumigatus

Journal of Fungi, 2020
The first characterized antifungal in the orotomide class is olorofim. It targets the de novo pyrimidine biosynthesis pathway by inhibiting dihydroorotate dehydrogenase (DHODH).
Saskia du Pré, Mike Birch, Derek Law, Nicola Beckmann, Graham E. M. Sibley, Michael J. Bromley, Nick D. Read, Jason D. Oliver   +7 more
doaj   +1 more source

Novel Aminopyrimidine-2,4-diones, 2-Thiopyrimidine-4-ones, and 6-Arylpteridines as Dual-Target Inhibitors of BRD4/PLK1: Design, Synthesis, Cytotoxicity, and Computational Studies

Pharmaceuticals, 2023
Structural-based drug design and solvent-free synthesis were combined to obtain three novel series of 5-arylethylidene-aminopyrimidine-2,4-diones (4, 5a–c, 6a,b), 5-arylethylidene-amino-2-thiopyrimidine-4-ones (7,8), and 6-arylpteridines (9,10) as dual ...
Samar El-Kalyoubi, Samiha A. El-Sebaey, Sherin M. Elfeky, Hanan A. AL-Ghulikah, Mona S. El-Zoghbi   +4 more
doaj   +1 more source

C–C (alkynylation) vs C–O (ether) bond formation under Pd/C–Cu catalysis: synthesis and pharmacological evaluation of 4-alkynylthieno[2,3-d]pyrimidines

Beilstein Journal of Organic Chemistry, 2011
The Pd/C–CuI–PPh3 catalytic system facilitated C–C bond formation between 4-chlorothieno[2,3-d]pyrimidines and terminal alkynes in methanol with high selectivity without generating any significant side products arising from C–O bond formation between the
Dhilli Rao Gorja, K. Shiva Kumar, K. Mukkanti, Manojit Pal   +3 more
doaj   +1 more source

In Silico Screening of the Library of Pyrimidine Derivatives as Thymidylate Synthase Inhibitors for Anticancer Activity

E-Journal of Chemistry, 2009
We here report the virtual screening of several series of pyrimidine derivatives for in silico Thymidylate Synthase (TS) inhibition to arrive at possible potential inhibitors of TS with acceptable pharmacokinetic or ADME (Absorption, Distribution ...
A. G. Nerkar, S. A. Ghone, A. K. Thaker
doaj   +1 more source

Comparative assessment of stability of fungicides triazolopyrimidine, triazole, pyrimidine and morpholine in the soil and prediction of groundwater pollution with them.

Medičnì Perspektivi, 2016
The purpose of our study was prediction of ground water contamination with fungicides of different chemical classes in soil-climatic conditions of Ukraine and other European countries and hygienic assessment of their harmful effects on human health.
S. V. Bіlous, S. T. Omel'chuk, O. P. Vavrіnevich, A. M. Antonenko   +3 more
doaj   +1 more source

Design and Synthesis of New 4-(3,4,5-Trimethoxyphenyl)Thiazole–Pyrimidine Derivatives as Potential Antiproliferative Agents

Medicina, 2023
A new series of 3,4,5-trimethoxyphenyl thiazole pyrimidines has been synthesized and biologically evaluated for its in vitro anticancer activity. Compounds 4a, 4b, and 4h with substituted piperazine showed the best antiproliferative activity.
Ashraf K. El-Damasy, Heewon Jin, Mohamed A. Sabry, Hyun Ji Kim, Mohammed M. Alanazi, Seon Hee Seo, Eun-Kyoung Bang, Gyochang Keum   +7 more
doaj   +1 more source

Anti-Mycobacterial Activity of Flavonoid and Pyrimidine Compounds

Molecules, 2022
We evaluated the anti-mycobacterial effect of a flavonoid 5,7-dihydroxy-2-(4-hydroxyphenyl) 4H-chromen-4-one (1) and two pyrimidines, 4-hydroxy-2-dimethylamino-5-nitroso-6-aminopyrimidine (2) and 2-chloro-5-n-nonylpyrimidine (3) in vitro against ...
Saurabh Garg, Rakesh Kumar, Dennis Kunimoto, Gina R. Rayat   +3 more
doaj   +1 more source