Results 31 to 40 of about 48,430 (295)

Preparation and Characterization of Derivatives of Pyrimidines in two ways Clascical and Microwave [PDF]

مجلة جامعة الانبار للعلوم الصرفة, 2017
This study includes synthesis and characterization of new pyrimidine derivatives (R or Ar-2,3,4,6,7,8-hexahydroquinazolin-5(1H)-one), via of the reaction from cyclohexane-1,3-dione with aldehyde derivatives and guanidinehydrochlorid.
Waleed AL-Hiti, Samea J.Khammase, Bushra T.Mahdi   +2 more
doaj   +1 more source

The Dynamic Influence of Olorofim (F901318) on the Cell Morphology and Organization of Living Cells of Aspergillus fumigatus

Journal of Fungi, 2020
The first characterized antifungal in the orotomide class is olorofim. It targets the de novo pyrimidine biosynthesis pathway by inhibiting dihydroorotate dehydrogenase (DHODH).
Saskia du Pré, Mike Birch, Derek Law, Nicola Beckmann, Graham E. M. Sibley, Michael J. Bromley, Nick D. Read, Jason D. Oliver   +7 more
doaj   +1 more source

Triethylamine-Promoted Oxidative Cyclodimerization of 2H-Azirine-2-carboxylates to Pyrimidine-4,6-dicarboxylates: Experimental and DFT Study

Molecules, 2023
An unprecedented oxidative cyclodimerization reaction of 2H-azirine-2-carboxylates to pyrimidine-4,6-dicarboxylates under heating with triethylamine in air is described. In this reaction, one azirine molecule undergoes formal cleavage across the C-C bond
Timofei N. Zakharov, Pavel A. Sakharov, Mikhail S. Novikov, Alexander F. Khlebnikov, Nikolai V. Rostovskii   +4 more
doaj   +1 more source

C–C (alkynylation) vs C–O (ether) bond formation under Pd/C–Cu catalysis: synthesis and pharmacological evaluation of 4-alkynylthieno[2,3-d]pyrimidines

Beilstein Journal of Organic Chemistry, 2011
The Pd/C–CuI–PPh3 catalytic system facilitated C–C bond formation between 4-chlorothieno[2,3-d]pyrimidines and terminal alkynes in methanol with high selectivity without generating any significant side products arising from C–O bond formation between the
Dhilli Rao Gorja, K. Shiva Kumar, K. Mukkanti, Manojit Pal   +3 more
doaj   +1 more source

In Silico Screening of the Library of Pyrimidine Derivatives as Thymidylate Synthase Inhibitors for Anticancer Activity

E-Journal of Chemistry, 2009
We here report the virtual screening of several series of pyrimidine derivatives for in silico Thymidylate Synthase (TS) inhibition to arrive at possible potential inhibitors of TS with acceptable pharmacokinetic or ADME (Absorption, Distribution ...
A. G. Nerkar, S. A. Ghone, A. K. Thaker
doaj   +1 more source

Comparative assessment of stability of fungicides triazolopyrimidine, triazole, pyrimidine and morpholine in the soil and prediction of groundwater pollution with them.

Medičnì Perspektivi, 2016
The purpose of our study was prediction of ground water contamination with fungicides of different chemical classes in soil-climatic conditions of Ukraine and other European countries and hygienic assessment of their harmful effects on human health.
S. V. Bіlous, S. T. Omel'chuk, O. P. Vavrіnevich, A. M. Antonenko   +3 more
doaj   +1 more source

Synthesis, characterisation and biological activities of N-phenyl-ethan-1-one-2,4-dimethyl-1,3-butadiene-1,4-thiazin derivatives

Tikrit Journal of Pure Science, 2023
A facile synthesis of some new 1, 2- thiazine derivatives by the Claisen-Schmidt reaction-induced aldolic condensation of enolizable aromatic ketones with substituted benzaldehydes, and then they were treated with urea and thiourea to obtain the ...
Nabaz Abdulmajeed Mohammad Salih
doaj   +1 more source

Parallel Synthesis of 2-Substituted 6-(5-Oxo-1-phenylpyrrolidin-3-yl)pyrimidine-5-carboxamides

Molecules, 2012
A library of 24 6-(5-oxo-1-phenylpyrrolidin-3-yl)pyrimidine-5-carboxamides <strong>10</strong>{<em>1</em>,<em>2</em>; <em>1–12</em>} was prepared by a parallel solution-phase approach.
Branko Stanovnik, Uroš Grošelj, Jurij Svete, Georg Dahmann, Drago Kočar, Jernej Baškovč, Bojana Črček   +6 more
doaj   +1 more source

Influence of 5-hydroxymethyluracil on the dynamics of angiogenic growth factors in the perioperative period of surgical myocardial revascularization: results of a randomized trial

Российский кардиологический журнал, 2023
Aim. To evaluate the effect of 5-hydroxymethyluracil on the dynamics of angiogenic growth factors in the perioperative period of surgical myocardial revascularization.Material and methods.
B. A. Oleynik, V. V. Plechev, V. A. Evdakov, R. I. Izhbuldin, N. Sh. Zagidullin   +4 more
doaj   +1 more source

Deoxyribonucleotide Triphosphate Metabolism in Cancer and Metabolic Disease

Frontiers in Endocrinology, 2018
The maintenance of a healthy deoxyribonucleotide triphosphate (dNTP) pool is critical for the proper replication and repair of both nuclear and mitochondrial DNA.
Raquel Buj, Katherine M. Aird
doaj   +1 more source