Results 11 to 20 of about 48,430 (295)

Annellation of Triazole and Tetrazole Systems onto Pyrrolo[2,3-d]pyrimidines: Synthesis of Tetrazolo[1,5-c]-pyrrolo[3,2-e]-pyrimidines and Triazolo[1,5-c]pyrrolo-[3,2-e]pyrimidines as Potential Antibacterial Agents

Molecules, 2002
Syntheses of several novel 4-chloropyrrolo[2,3-d]pyrimidines (1), 4-hydrazinopyrrolo[2,3-d]pyrimidines (2) and 3-amino-4-iminopyrrolo[2,3-d]pyrimidines (7) and their use in the synthesis of tetrazolo[1,5-c]pyrrolo[3,2-e]pyrimidines (3) and triazolo[1,5-c]
Chaitanya G Dave, Rina D Shāh
exaly   +4 more sources

Selective Covalent Targeting of Mutated EGFR(T790M) with Chlorofluoroacetamide-Pyrimidines

, 2020
Covalent modification of disease-associated proteins with small molecules is a powerful approach for achieving an increased and sustained pharmacological effect.
Naoya Matsunaga (8697018), Tomohiro Shibata (336448), Mami Sato (1810039), Naoya Shindo (8697003), Keiko Kuwata (1921681), Ryo Inamori (8697012), Satoru Koyanagi (8697021), Mayumi Ono (150799), Kosuke Watari (314824), Akio Ojida (1414159), Hirokazu Fuchida (8697000), Keitaro Hosokawa (8697015), Keisuke Tokunaga (8697006), Guo Xiao-Lin (8697009), Shigehiro Ohdo (8697024)   +14 more
core   +5 more sources

CuO/ZnO@N-GQDs@NH2 nanocomposite as superior catalyst for the synthesis of pyrimidine-triones [PDF]

Nanochemistry Research, 2021
CuO / ZnO@N - GQDs@NH2 nanocomposite (copper (II) oxide / zinc oxide @ Nitrogen-doped graphene quantum dots @ aminated) as superior catalyst has been applied for the synthesis of pyrimidine - trions by three-component reactions of N, N ...
Hossein Shahbazi-Alavi, Seyyed Mohammad Ebrahimi, Javad Safaei-Ghomi   +2 more
doaj   +1 more source

Review on the Synthesis and Therapeutic Potential of Pyrido[2,3-d], [3,2-d], [3,4-d] and [4,3-d]pyrimidine Derivatives

Pharmaceuticals, 2022
The objective of this review is to list the structures composed of a pyridopyrimidine moiety which have shown a therapeutic interest or have already been approved for use as therapeutics.
Joana F. Campos, Thierry Besson, Sabine Berteina-Raboin   +2 more
doaj   +1 more source

SYNTHESIS, REACTIONS AND ANTITUMOR EVALUATION OF SOME POLYCONDENSED THIAZOLOPYRIMIDINE DERIVATIVES [PDF]

Al-Azhar Journal of Pharmaceutical Sciences, 2012
Some novel thiazolo[3,2-a]pyrimidines, pyrimidino[1',2':3,2]thiazolo[4,5-b] pyridines,pyrimidino[1'',2'':3',2']thiazolo[4',5':2,3]pyrido-[2,3-d]pyrimidines, pyrimidino [1',2':3,2]thiazolo[4,5-d]pyrimidines, pyrimidino[1',2':3,2]thiazolo[4,5-d][1,2,4 ...
Nermin El-Seadawy
doaj   +1 more source

Inhibitors of Nucleotide Biosynthesis as Candidates for a Wide Spectrum of Antiviral Chemotherapy

Microorganisms, 2022
Emerging and re-emerging viruses have been a challenge in public health in recent decades. Host-targeted antivirals (HTA) directed at cellular molecules or pathways involved in virus multiplication represent an interesting strategy to combat viruses ...
Claudia Soledad Sepúlveda, Cybele Carina García, Elsa Beatriz Damonte   +2 more
doaj   +1 more source

Amino Derivatives of Diaryl Pyrimidines and Azolopyrimidines as Protective Agents against LPS-Induced Acute Lung Injury

Molecules, 2023
The problem of lung damage originating from excessive inflammation and cytokine release during various types of infections remains relevant and stimulates the search for highly effective and safe drugs.
Alexander Spasov, Irina Ovchinnikova, Olga Fedorova, Yulia Titova, Denis Babkov, Vadim Kosolapov, Alexander Borisov, Elena Sokolova, Vladlen Klochkov, Maria Skripka, Yulia Velikorodnaya, Alexey Smirnov, Gennady Rusinov, Valery Charushin   +13 more
doaj   +1 more source

In Silico Evaluation of a Promising Key Intermediate Thieno [2,3-d] Pyrimidine Derivative with Expected JAK2 Kinase Inhibitory Activity

Molbank, 2022
This work describes the synthesis and the cytotoxic evaluation of thiophene and thienopyrimidine derivatives. The investigated compound was subjected to target prediction that indicated its high affinity to kinases and to Janus kinase 2 (JAK2 ...
Elshaymaa I. Elmongy, Hanan Ali Henidi
doaj   +1 more source

Unusual nucleophilic addition of Grignard reagents in the synthesis of 4-amino-pyrimidines [PDF]

, 2018
Pyrimidines have always received considerable attention because of their importance in synthesis and elucidation of biochemical roles, in particular that of vitamin B1.
David L. Hughes (628280), Ward, Leanne, Stephenson, G. Richard, Tinson, Ryan A. J., Ryan A. J. Tinson (5620037), Hughes, David L., Leanne Ward (4383349), G. Richard Stephenson (1930399)   +7 more
core   +1 more source

Proficient synthesis of bioactive annulated pyrimidine derivatives: A review

Journal of Taibah University for Science, 2017
Syntheses of bioactive annulated pyrimidine derivatives are the most significant tasks in N-heterocyclic chemistry because these compounds have proved to be very attractive and useful for the design of new molecular frameworks of potential drugs with ...
Ajmal R. Bhat, Rajendra S. Dongre, Gowhar A. Naikoo, Israr U. Hassan, Tabassum Ara   +4 more
doaj   +1 more source