Results 11 to 20 of about 48,617 (303)

Selective Covalent Targeting of Mutated EGFR(T790M) with Chlorofluoroacetamide-Pyrimidines [PDF]

, 2020
Covalent modification of disease-associated proteins with small molecules is a powerful approach for achieving an increased and sustained pharmacological effect.
Naoya Matsunaga (8697018), Tomohiro Shibata (336448), Mami Sato (1810039), Naoya Shindo (8697003), Keiko Kuwata (1921681), Ryo Inamori (8697012), Satoru Koyanagi (8697021), Mayumi Ono (150799), Kosuke Watari (314824), Akio Ojida (1414159), Hirokazu Fuchida (8697000), Keitaro Hosokawa (8697015), Keisuke Tokunaga (8697006), Guo Xiao-Lin (8697009), Shigehiro Ohdo (8697024)   +14 more
core   +9 more sources

Ruthenium(II)-Catalyzed Positional Selective C–H Oxygenation of N‑Aryl-2-pyrimidines [PDF]

, 2018
Efficient Ru-catalyzed regioselective C–H oxygenation of N-aryl-2-pyrimidines is described with aryl carboxylic acids in the presence of AgSbF6 as an additive and Ag2CO3 as an oxidant.
Tharmalingam Punniyamurthy (1490761), Sourav Pradhan (3814492), Tanumay Sarkar (5277467)   +2 more
core   +3 more sources

Unusual nucleophilic addition of Grignard reagents in the synthesis of 4-amino-pyrimidines [PDF]

, 2018
Pyrimidines have always received considerable attention because of their importance in synthesis and elucidation of biochemical roles, in particular that of vitamin B1.
David L. Hughes (628280), Ward, Leanne, Stephenson, G. Richard, Tinson, Ryan A. J., Ryan A. J. Tinson (5620037), Hughes, David L., Leanne Ward (4383349), G. Richard Stephenson (1930399)   +7 more
core   +1 more source

Structure based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1 [PDF]

, 2014
The treatment of Human African Trypanosomiasis remains a major unmet health need in sub-Saharan Africa. Approaches involving new molecular targets are important and pteridine reductase 1 (PTR1), an enzyme that reduces dihydrobiopterin in Trypanosoma spp.
Kirsten Stewart, Michael P. Barrett, Pui Ee Wong, William N. Hunter, Barrack, Keri L., Hunter, William N., Huggan, Judith, Colin L. Gibson, Judith K. Huggan, Barrett, Michael P., Federica Giordani, Suckling, Colin J., Colin J. Suckling, Khalaf, Abedawn I., Huggan, Judith K., Wong, Pui Ee, Khalaf, Abedawn I, Barrack, Keri L, Stewart, Kirsten, Keri L. Barrack, Suckling, Colin J, Hunter, Wililam N., Gibson, Colin L., Giordani, Federica, Gibson, Colin L, Abedawn I. Khalaf, Hunter, William N   +26 more
core   +1 more source

Influence of 5-hydroxymethyluracil on the dynamics of angiogenic growth factors in the perioperative period of surgical myocardial revascularization: results of a randomized trial

Российский кардиологический журнал, 2023
Aim. To evaluate the effect of 5-hydroxymethyluracil on the dynamics of angiogenic growth factors in the perioperative period of surgical myocardial revascularization.Material and methods.
B. A. Oleynik, V. V. Plechev, V. A. Evdakov, R. I. Izhbuldin, N. Sh. Zagidullin   +4 more
doaj   +1 more source

Medicinal attributes of pyrazolo[1,5-a]pyrimidine based scaffold derivatives targeting kinases as anticancer agents

Future Journal of Pharmaceutical Sciences, 2016
Pyrazolo pyrimidines are fused heterocyclic ring systems which known as bioisosteres of adenine, that are necessary for every aspect of cell life. Pyrazolo[1,5-a]pyrimidines derivatives have been explored for their inhibitory activity towards a variety ...
Nasser S.M. Ismail, Ghada M.E. Ali, Diaa A. Ibrahim, Amira M. Elmetwali   +3 more
doaj   +1 more source

Synthesis of pyrimidines by Fe3O4@SiO2-L-proline nanoparticles

Main Group Metal Chemistry, 2020
Fe3O4@SiO2-L-proline nanoparticles have been used as an effective catalyst for the preparation of pyrimidines by three-component reactions of 1,3-dimethylbarbituric acid, aromatic aldehydes and 4-methyl aniline or 4-methoxy aniline under reflux condition
Safaei-Ghomi Javad, Samadi Zahra
doaj   +1 more source

Design, Synthesis, Pharmacodynamic and In Silico Pharmacokinetic Evaluation of Some Novel Biginelli-Derived Pyrimidines and Fused Pyrimidines as Calcium Channel Blockers

Molecules, 2022
Some new pyrimidine derivatives comprising arylsulfonylhydrazino, ethoxycarbonylhydrazino, thiocarbamoylhydrazino and substituted hydrazone and thiosemicarbazide functionalities were prepared from Biginelli-derived pyrimidine precursors.
Ahmed M. Farghaly, Ola H. Rizk, Inas Darwish, Manal Hamza, Mezna Saleh Altowyan, Assem Barakat, Mohamed Teleb   +6 more
doaj   +1 more source

Development of Piperazine- and Oxazine-Linked Pyrimidines as p65 Subunit Binders of NF–κB in Human Breast Cancer Cells

Biomedicines, 2023
Nuclear factor kappa B (NF–κB) is a potential therapeutic target in breast cancer. In the current study, a new class of oxazine– and piperazine–linked pyrimidines was developed as inhibitors of NF–κB, overcoming the complexity of the oxazine structure ...
Akshay Ravish, Bhanuprakash C. Narasimhachar, Zhang Xi, Divakar Vishwanath, Arunkumar Mohan, Santosh L. Gaonkar, Paduvalahippe Gowdegowda Chandrashekara, Kwang Seok Ahn, Vijay Pandey, Peter E. Lobie, Basappa Basappa   +10 more
doaj   +1 more source

Preparation and Diagnosis of Pyrimidines Derivatives by Conventional And Microwave Ways. [PDF]

مجلة جامعة الانبار للعلوم الصرفة, 2017
This work includes synthesis and characterization of new derivatives of pyrimidine (R. or Ar. -1, 2, 3, 4-tetrahydropyrimidin-5-yl) ethan-1-one), via the reaction of acetyl acetone with different aldehydes and guanidine hydrochloride.
Waleed F. AL-Hiti, Samea J. Khammase, Bushra T. Mahdi   +2 more
doaj   +1 more source