Results 11 to 20 of about 11,360 (191)

Selective Covalent Targeting of Mutated EGFR(T790M) with Chlorofluoroacetamide-Pyrimidines

, 2020
Covalent modification of disease-associated proteins with small molecules is a powerful approach for achieving an increased and sustained pharmacological effect.
Naoya Matsunaga (8697018), Tomohiro Shibata (336448), Mami Sato (1810039), Naoya Shindo (8697003), Keiko Kuwata (1921681), Ryo Inamori (8697012), Satoru Koyanagi (8697021), Mayumi Ono (150799), Kosuke Watari (314824), Akio Ojida (1414159), Hirokazu Fuchida (8697000), Keitaro Hosokawa (8697015), Keisuke Tokunaga (8697006), Guo Xiao-Lin (8697009), Shigehiro Ohdo (8697024)   +14 more
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Unusual nucleophilic addition of Grignard reagents in the synthesis of 4-amino-pyrimidines [PDF]

, 2018
Pyrimidines have always received considerable attention because of their importance in synthesis and elucidation of biochemical roles, in particular that of vitamin B1.
David L. Hughes (628280), Ward, Leanne, Stephenson, G. Richard, Tinson, Ryan A. J., Ryan A. J. Tinson (5620037), Hughes, David L., Leanne Ward (4383349), G. Richard Stephenson (1930399)   +7 more
core   +1 more source

Influence of 5-hydroxymethyluracil on the dynamics of angiogenic growth factors in the perioperative period of surgical myocardial revascularization: results of a randomized trial

Российский кардиологический журнал, 2023
Aim. To evaluate the effect of 5-hydroxymethyluracil on the dynamics of angiogenic growth factors in the perioperative period of surgical myocardial revascularization.Material and methods.
B. A. Oleynik, V. V. Plechev, V. A. Evdakov, R. I. Izhbuldin, N. Sh. Zagidullin   +4 more
doaj   +1 more source

SYNTHESIS OF 5-SUBSTITUTED PYRIMIDINES.

, 1963
SYNTHESIS OF 5-SUBSTITUTED ...
TARAKAD VENKATESWAR. RAJKUMAR (7989017)
core   +4 more sources

Medicinal attributes of pyrazolo[1,5-a]pyrimidine based scaffold derivatives targeting kinases as anticancer agents

Future Journal of Pharmaceutical Sciences, 2016
Pyrazolo pyrimidines are fused heterocyclic ring systems which known as bioisosteres of adenine, that are necessary for every aspect of cell life. Pyrazolo[1,5-a]pyrimidines derivatives have been explored for their inhibitory activity towards a variety ...
Nasser S.M. Ismail, Ghada M.E. Ali, Diaa A. Ibrahim, Amira M. Elmetwali   +3 more
doaj   +1 more source

Synthesis of pyrimidines by Fe3O4@SiO2-L-proline nanoparticles

Main Group Metal Chemistry, 2020
Fe3O4@SiO2-L-proline nanoparticles have been used as an effective catalyst for the preparation of pyrimidines by three-component reactions of 1,3-dimethylbarbituric acid, aromatic aldehydes and 4-methyl aniline or 4-methoxy aniline under reflux condition
Safaei-Ghomi Javad, Samadi Zahra
doaj   +1 more source

Design, Synthesis, Pharmacodynamic and In Silico Pharmacokinetic Evaluation of Some Novel Biginelli-Derived Pyrimidines and Fused Pyrimidines as Calcium Channel Blockers

Molecules, 2022
Some new pyrimidine derivatives comprising arylsulfonylhydrazino, ethoxycarbonylhydrazino, thiocarbamoylhydrazino and substituted hydrazone and thiosemicarbazide functionalities were prepared from Biginelli-derived pyrimidine precursors.
Ahmed M. Farghaly, Ola H. Rizk, Inas Darwish, Manal Hamza, Mezna Saleh Altowyan, Assem Barakat, Mohamed Teleb   +6 more
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Structure based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1 [PDF]

, 2014
The treatment of Human African Trypanosomiasis remains a major unmet health need in sub-Saharan Africa. Approaches involving new molecular targets are important and pteridine reductase 1 (PTR1), an enzyme that reduces dihydrobiopterin in Trypanosoma spp.
Kirsten Stewart, Michael P. Barrett, Pui Ee Wong, William N. Hunter, Barrack, Keri L., Hunter, William N., Huggan, Judith, Colin L. Gibson, Judith K. Huggan, Barrett, Michael P., Federica Giordani, Suckling, Colin J., Colin J. Suckling, Khalaf, Abedawn I., Huggan, Judith K., Wong, Pui Ee, Khalaf, Abedawn I, Barrack, Keri L, Stewart, Kirsten, Keri L. Barrack, Suckling, Colin J, Hunter, Wililam N., Gibson, Colin L., Giordani, Federica, Gibson, Colin L, Abedawn I. Khalaf, Hunter, William N   +26 more
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Ruthenium(II)-Catalyzed Positional Selective C–H Oxygenation of N‑Aryl-2-pyrimidines

, 2018
Efficient Ru-catalyzed regioselective C–H oxygenation of N-aryl-2-pyrimidines is described with aryl carboxylic acids in the presence of AgSbF6 as an additive and Ag2CO3 as an oxidant.
Tharmalingam Punniyamurthy (1490761), Sourav Pradhan (3814492), Tanumay Sarkar (5277467)   +2 more
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Palladium-Catalyzed Intramolecular Cross-Dehydrogenative Coupling: Synthesis of Fused Imidazo[1,2‑a]pyrimidines and Pyrazolo[1,5‑a]pyrimidines [PDF]

, 2017
A palladium-catalyzed intramolecular dehydrogenative coupling reaction was developed for the synthesis of fused imidazo[1,2-a]pyrimidines and pyrazolo[1,5-a]- pyrimidines.
Wang, Jeh-Jeh, Keykavous Parang, Jaya Kishore Vandavasi, Siva K. Reddy Kotla, Rakesh K. Tiwari, Kotla, Siva K. Reddy, Vandavasi, Jaya Kishore, Parang, Keykavous, Jeh-Jeng Wang, Tiwari, Rakesh   +9 more
core   +1 more source