Results 21 to 30 of about 48,430 (295)
Structure based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1 [PDF]
, 2014 The treatment of Human African Trypanosomiasis remains a major unmet health need in sub-Saharan Africa. Approaches involving new molecular targets are important and pteridine reductase 1 (PTR1), an enzyme that reduces dihydrobiopterin in Trypanosoma spp.
Kirsten Stewart +26 more
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Synthesis of pyrimidines using nano-NiZr4 (PO4)6 as a retrievable and robust heterogeneous catalyst [PDF]
Nanochemistry Research, 2020 Nano-NiZr4 (PO4)6 has been used as an effective and retrievable heterogeneous catalyst for the synthesis of pyrimidines through the reaction of benzaldehydes, guanidinehydrochloride and malononitrile under reflux conditions in ethanol.
Hossein Shahbazi-Alavi +1 more
doaj +1 more source
Future Journal of Pharmaceutical Sciences, 2016 Pyrazolo pyrimidines are fused heterocyclic ring systems which known as bioisosteres of adenine, that are necessary for every aspect of cell life. Pyrazolo[1,5-a]pyrimidines derivatives have been explored for their inhibitory activity towards a variety ...
Nasser S.M. Ismail +3 more
doaj +1 more source
Synthesis of pyrimidines by Fe3O4@SiO2-L-proline nanoparticles
Main Group Metal Chemistry, 2020 Fe3O4@SiO2-L-proline nanoparticles have been used as an effective catalyst for the preparation of pyrimidines by three-component reactions of 1,3-dimethylbarbituric acid, aromatic aldehydes and 4-methyl aniline or 4-methoxy aniline under reflux condition
Safaei-Ghomi Javad, Samadi Zahra
doaj +1 more source
Computational Estimation of the Acidities of Pyrimidines and Related Compounds
Molecules, 2022 Pyrimidines are key components in the genetic code of living organisms and the pyrimidine scaffold is also found in many bioactive and medicinal compounds. The acidities of these compounds, as represented by their pKas, are of special interest since they
Rachael A. Holt, Paul G. Seybold
doaj +1 more source
Synthesis of Pyrimidines and Condensed Pyrimidines [PDF]
Bulletin of the Chemical Society of Japan, 1973 Abstract A new one-step synthesis of pyrimidines and condensed pyrimidines by heating carboxamides or cyclic lactams with formamide in the presence of POCl3 in a sealed tube is described.
openaire +1 more source
Ruthenium(II)-Catalyzed Positional Selective C–H Oxygenation of N‑Aryl-2-pyrimidines
, 2018 Efficient Ru-catalyzed regioselective C–H oxygenation of N-aryl-2-pyrimidines is described with aryl carboxylic acids in the presence of AgSbF6 as an additive and Ag2CO3 as an oxidant.
Tharmalingam Punniyamurthy (1490761) +2 more
core +2 more sources
Design and Synthesis of New Pyrimidine-Quinolone Hybrids as Novel hLDHA Inhibitors
Pharmaceuticals, 2022 A battery of novel pyrimidine-quinolone hybrids was designed by docking scaffold replacement as lactate dehydrogenase A (hLDHA) inhibitors. Structures with different linkers between the pyrimidine and quinolone scaffolds (10-21 and 24–31) were studied in
Iván Díaz +3 more
doaj +1 more source
Sonosynthesis of Pyrimidines as Antimicrobial Agents Using Nano-Fe3O4–L-cysteine [PDF]
Nanochemistry Research, 2022 Nano-Fe3O4–L-cysteine as a superior catalyst was applied for the synthesis of pyrimidine-trions by three-component reactions of N,N-dimethylbarbituric acid, benzaldehydes and para-methyl aniline or para-methoxy aniline under ultrasonic irradiation in ...
Hossein Shahbazi-Alavi +1 more
doaj +1 more source
Molecules, 2023 The present work describes the design and development of seventeen pyrimidine-clubbed benzimidazole derivatives as potential dihydrofolate reductase (DHFR) inhibitors.
M. Akiful Haque +11 more
doaj +1 more source