Results 71 to 80 of about 48,430 (295)

Iron-Catalyzed Alkyne-Based Multicomponent Synthesis of Pyrimidines under Air

, 2021
An iron-catalyzed sustainable, economically affordable, and eco-friendly synthetic protocol for the construction of various trisubstituted pyrimidines is described.
Gargi Chakraborty, Susmita Sarkar (332225), Amit Kumar Guin, Rakesh Mondal (5676512), Amit Kumar Guin (9766725), Nanda D. Paul, Rakesh Mondal, Gargi Chakraborty (5676509), Nanda D. Paul (2158771), Susmita Sarkar   +9 more
core   +1 more source

Dipole‐Manipulated Built‐In Electric Field Enables Ultrafast Charge Separation in Perylene Diimide Polymers for Photoelectrochemical Water Splitting

Advanced Science, EarlyView.
Molecular dipole engineering in dendritic perylene diimide polymers through nitrogen‐rich heterocyclic linkers amplifies the built‐in electric field, enabling sub‐picosecond charge separation and efficient multi‐electron accumulation. This structure–dynamics–performance relationship establishes a versatile design strategy for high‐performance organic ...
Ying‐Xin Qiao, Zicong Situ, Yi‐Jing Chen, Shuo‐Xiang Liu, Jing‐Lan Zhang, Xingqing Li, Luo‐Han Xie, Si‐Hang Xie, Qing‐Xiao Tong, Andong Xia, Zhuoran Kuang, Jing‐Xin Jian   +11 more
wiley   +1 more source

Stage‐Specific H3K14 and H3K23 Succinylation Orchestrates Insect Metamorphosis and Oogenesis

Advanced Science, EarlyView.
Stage‐specific succinylation of histone H3 at lysine 14 and 23 differentially controls insect metamorphosis and oogenesis through distinct GPCR‐PKC signaling cascades, revealing an evolutionarily conserved epigenetic mechanism that coordinates key life‐history traits.
Yu‐Pu Jing, Lunjie Li, Libin Yang, Lin‐Jie Zhang, Qiang Yan, Ci Zhang, Zanrong Wen, Guangze Yu, Qian Li, Shutang Zhou   +9 more
wiley   +1 more source

Serendipitous Identification of Azine Anticancer Agents Using a Privileged Scaffold Morphing Strategy

Molecules
The use of privileged scaffolds as a starting point for the construction of libraries of bioactive compounds is a widely used strategy in drug discovery and development.
Silvia Cesarini, Ilaria Vicenti, Federica Poggialini, Silvia Filippi, Eleonora Mancin, Lia Fiaschi, Elisa De Marchi, Federica Giammarino, Chiara Vagaggini, Bruno Mattia Bizzarri, Raffaele Saladino, Elena Dreassi, Maurizio Zazzi, Lorenzo Botta   +13 more
doaj   +1 more source

Synthesis and Antibacterial Evaluation of Novel Heterocyclic Compounds Containing a Sulfonamido Moiety

Molecules, 2013
Aiming for the synthesis of new heterocyclic compounds containing a sulfonamido moiety suitable for use as antibacterial agents, the precursor ethyl {[4-N-(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenylazo}cyanoacetate was reacted with a variety of active ...
Eman A. El-Bordany, Mohamed M. Youssef, Mohammad Emad Azab   +2 more
doaj   +1 more source

Allosteric Inhibition of Polycomb Repressive Complex 2 by an EZH2‐Selective Small Molecule Inhibitor

Advanced Science, EarlyView.
The study characterizes C36, a highly selective EZH2/PRC2 inhibitor that acts via a novel allosteric mechanism. Unlike previous inhibitors, C36 inhibits EZH2/PRC2 by disrupting the allosteric communication between EZH2 and EED in a SAM‐noncompetitive manner.
Ting Cao, Dongdong Liu, Haishan Gao, Chenyang Qin, Wen Zhang, Ziyun Lu, Dongxia Tan, Yuxiu Qu, Yusong Liu, Zhiran Zou, Hongtao Yu, Wei Qi   +11 more
wiley   +1 more source

Synthesis of substituted 8H-benzo[h]pyrano[2,3-f]quinazolin-8-ones via photochemical 6π-electrocyclization of pyrimidines containing an allomaltol fragment

Beilstein Journal of Organic Chemistry, 2023
For the first time, we elaborated a method for the synthesis of pyrimidines containing an allomaltol unit. The suggested approach is based on the reaction of 2-(1-(dimethylamino)-3-oxo-3-arylprop-1-en-2-yl)-3-hydroxy-6-methyl-4H-pyran-4-ones with ...
Constantine V. Milyutin, Andrey N. Komogortsev, Boris V. Lichitsky, Mikhail E. Minyaev, Valeriya G. Melekhina   +4 more
doaj   +1 more source

NAD+ Metabolism Licenses Zygotic Genome Activation via PARP7‐Mediated ADP‐Ribosylation of UHRF1 in Mouse Early Embryos

Advanced Science, EarlyView.
This study uncovers a metabolic‐epigenetic axis licensing zygotic genome activation (ZGA) in mouse embryos. A developmental decline in NAD+ levels activates PARP7, which mono‐ADP‐ribosylates and stabilizes UHRF1. This modification promotes the establishment of permissive histone acetylation marks, thereby facilitating timely ZGA.
Guangyi Cao, Ziqi Zhang, Anqi Chen, Yanbo Liu, Yuling Lin, Lina Yu, Ruixin Shi, Aolei Guo, Yan Mao, Ganggui Lou, Chaojun Li, Luhong Wen, Guijun Yan, Haixiang Sun   +13 more
wiley   +1 more source

]pyrimidines

, 2015
The reaction of 3(5)-amino-5(3)-hydrazinopyrazole, a bifunctional compound, with 3-oxo-3-phenylpropanenitrile and two of its p-substituted derivatives affords 2,5-diaryl-7-aminopyrazolo[1,5-a]pyrimidines.
Claramunt, R.M., José Elguero, Rosa M. Claramunt, Alkorta, I., Elguero, J., Sanz, D., Dionisia Sanz, Goar Sánchez‐Sanz, Aggarwal, R., Virender Kumar, Gulshan Singh, Ranjana Aggarwal, Ibon Alkorta, Kumar, V., Singh, G., Sánchez-Sanz, G.; id_orcid   +15 more
core   +1 more source

Purine and pyrimidine synthesis differently affect the strength of the inoculum effect for aminoglycoside and β-lactam antibiotics

Microbiology Spectrum
The inoculum effect has been observed for nearly all antibiotics and bacterial species. However, explanations accounting for its occurrence and strength are lacking.
Daniella M. Hernandez, Melissa Marzouk, Madeline Cole, Marla C. Fortoul, Saipranavi Reddy Kethireddy, Rehan Contractor, Habibul Islam, Trent Moulder, Ariane R. Kalifa, Estefania Marin Meneses, Maximiliano Barbosa Mendoza, Ruth Thomas, Saad Masud, Sheena Pubien, Patricia Milanes, Gabriela Diaz-Tang, Allison J. Lopatkin, Robert P. Smith   +17 more
doaj   +1 more source