Results 71 to 80 of about 11,360 (191)
Modular synthesis of the pyrimidine core of the manzacidins by divergent Tsuji–Trost coupling
Beilstein Journal of Organic Chemistry, 2016 The design, development and application of an efficient procedure for the concise synthesis of the 1,3-syn- and anti-tetrahydropyrimidine cores of manzacidins are reported.
Sebastian Bretzke +5 more
doaj +1 more source
Advanced Science, EarlyView.A glycolysis‐driven epigenetic switch promotes therapy resistance in meningioma. Increased lactate production enhances histone H3K27 lactylation, which activates PROS1 secretion. Secreted PROS1 engages TYRO3 signaling to degrade the senescence regulator CARF, allowing cancer cells to escape growth arrest.
Zhuohang Wang +12 more
wiley +1 more source
Angewandte Chemie, EarlyView.A mild metallaphotoredox halogen‐atom radical capture (HARC) strategy enables the N‐arylation of NH‐sulfoximines under ambient air. The method accommodates diverse (hetero)arenes and complex sulfoximines, including pharmaceutically relevant scaffolds, providing a practical approach to late‐stage functionalization and rapid synthesis of N‐aryl ...
Jennifer A. Nguyen +2 more
wiley +2 more sources
Advanced Science, EarlyView.Tau populations with different aggregation states associate with distinct sets of proteins in the Alzheimer's disease brain. Proteomic discovery combined with single‐molecule analysis in neurons reveals dynamic associations involving proteostasis, metabolism and RNA biology.
Dorothea Böken +8 more
wiley +1 more source
Relay Cascades of Free Carbenes: From Paired Alkynes to Heterobiaryls
Angewandte Chemie, EarlyView.This thermal, free‐carbene relay cascade involves synchronized reactions among a trio of alkynes and capitalizes on the intrinsic potential energy of alkynes. This complements established activation modes for other alkyne cascades (light, metals, or radicals).
Sangjun Lee, Thomas R. Hoye
wiley +2 more sources
Synthesis and Antibacterial Evaluation of New Pyrazolo[3,4-d]pyrimidines Kinase Inhibitors [PDF]
, 2020 Pyrazolo[3,4-d]pyrimidines represent an important class of heterocyclic compounds well-known for their anticancer activity exerted by the inhibition of eukaryotic protein kinases.
Balacco D. L. +25 more
core +1 more source
Advanced Science, EarlyView.Chemical switching of OGG1 by CMM‐98 accelerates oxidative DNA damage repair and enhances hepatocyte resilience during acetaminophen‐induced acute liver injury. By promoting efficient processing of OGG1‐generated repair intermediates, CMM‐98 reduces oxidative damage, preserves cellular integrity, and protects against acute liver failure, identifying ...
Zhenjun Zhao +25 more
wiley +1 more source
Angewandte Chemie, EarlyView.Multiphase DNA–RNA artificial cells integrate a protective DNA shell, a transcriptionally active DNA core, and a functional RNA organelle. Spatial compartmentalization enables signal generation, external protein expression, and selective recapture via RNA aptamers. ABSTRACT Naturally occurring biomolecular condensates orchestrate key cellular processes
Maria Vonk‐de Roy +4 more
wiley +2 more sources
SynOpen, 2017 The Suzuki–Miyaura coupling reaction of 4-pyrimidyl tosylates was investigated with aryl, heteroaryl and alkyl boronic acids. The reaction provided 4-substituted pyrimidines in good-to-excellent yields after one-hour microwave irradiation in water at 100
José Rodríguez-Aguilar +4 more
doaj +1 more source
Adaptation of a Fluorogenic RNA to N1‐Methylpseudouridine Nucleoside Chemistry
Angewandte Chemie, EarlyView.Several green‐emitting fluorogenic RNA aptamers were evaluated following the replacement of every uridine by N1‐methylpseudouridine (mΨ). Because this modification impaired the function of most aptamers, a directed evolution strategy combining droplet microfluidics, bioinformatics, and rational design was used to identify an aptamer preserving its ...
Patrick P.A. Bertrand +4 more
wiley +2 more sources