Results 211 to 220 of about 7,405 (269)

Pyrimidinones as reversible metaphase arresting agents

European Journal of Medicinal Chemistry, 1993
Abstract 5-Halo- N (1)-substituted 2(1 H )-pyrimidinones have the ability to cause reversible arrest of mitosis during metaphase. Highly active compounds have a heteroatom ( O , S or N ) in the β-position of the N (1)-carbon chain which is further substituted by an aryl group. In vitro data have been provided.
Reidar Oftebro, Per Strande, Tore Benneche, Kjell Undheim   +3 more
openaire   +2 more sources

Metal-free radical C–H methylation of pyrimidinones and pyridinones with dicumyl peroxide

, 2017
A new method for free radical methylation of pyrimidinones and pyridinones with dicumyl peroxide (DCP) under metal-free conditions is introduced. A 50 g-scale reaction could be performed safely at the desired concentration.
Pei-zhi Zhang, Jian-An Li, Ling Zhang, Adedamola Shoberu, J. Zou, Wei Zhang   +5 more
semanticscholar   +1 more source

Mn(OAc)3-Mediated Regioselective Radical Alkoxycarbonylation of Indoles, Pyrimidinones, and Pyridinones

Synthesis, 2018
Mn(OAc)3-mediated alkoxycarbonylation of indoles, pyrimidinones, and pyridinones with alkyl carbazates is reported. The reactions proceed through a radical process to afford regioselectively 3-carboxylated indoles, 5-carboxylated pyrimidinones, and 3 ...
Cheng-Kun Li, Dong‐Liang Zhang, Ogundipe Olukayode Olamiji, Pei-zhi Zhang, Adedamola Shoberu, J. Zou, Wei Zhang   +6 more
semanticscholar   +1 more source

Regioselectivity in reactions of alkynylmetal complexes with pyrimidinones

Journal of Organometallic Chemistry, 1985
Abstract Regioselectivity is observed in 1 1 -adduct formation between phenylethynyltriisopropoxytitanium and 2(1/ H )-pyrimidinones; the new carbon-carbon bond is formed at C(4). In contrast the 3,4- and 3,6-dihydro products are formed together from the corresponding magnesium and lithium reagents, but from the magnesium compound the major ...
Frode Rise, Kjell Undheim
openaire   +2 more sources

Synthesis and Antimicrobial Activity of Novel Azolopyrimidines and Pyrido-Triazolo-Pyrimidinones Incorporating Pyrazole Moiety

, 2017
A new series of azolopyrimidine derivatives incorporating pyrazole moiety were synthesized by reaction of 1-(pyrazol-3-yl)-2-propenone with a number of heterocyclic amines in the presence of a catalytic amount of acetic acid.
I. M. Abbas, M. A. Abdallah, Sobhi M. Gomha, Mariam S. H. Kazem   +3 more
semanticscholar   +1 more source

ChemInform Abstract: S_NAr Reactions of 2‐Methylthio‐4‐pyrimidinones in Pivalic Acid: Access to Functionalized Pyrimidinones and Pyrimidines.

ChemInform, 2012
AbstractThe efficient title reactions with anilines are achieved in pivalic acid as reaction medium.
Rhiannon Carter, Matthew L. Maddess
openaire   +3 more sources

(E)- and (Z)-Enamine Dewar Pyrimidinones [PDF]

Acta Crystallographica Section C Crystal Structure Communications, 1995
The structures of (E)- and (Z)-methyl 1,6-dimethyl-5-oxo-2,6-diazabicyclo[2.2.0]hex-3-ylideneacetate, C 9 H 12 N 2 O 3 , have been established by X-ray diffraction analyses. The 2-azetidinone ring, azetidine ring and enamine moiety in both isomers are quite planar.
Y. Takahashi, S. i. Hirokami, H. Kakuda
openaire   +1 more source

An efficient synthesis of thiazolo[3,2-a]pyrimidinones

Tetrahedron Letters, 2010
AbstractThe short approach includes condensation of 2‐aminothiazoles with diesters (II) followed by cyclization in the presence of commercially available Eaton′s reagent.
Keith Jones, Nadia M. Ahmad
openaire   +3 more sources

Antineoplastic properties of pyrimidinone interferon inducers

Advances in Enzyme Regulation, 1981
Abstract The interferon inducing, antiviral and antitumor activities of a new series of pyrimidinone compounds are compared and summarized in this report. An interesting split in mechanism of action appeared to exist in these compounds. One group represented by ABPP were very potent interferon inducing agents and the antiviral and antitumor activity ...
openaire   +3 more sources

Tuning the Annulation Reactivity of Vinyl Azides and Carbazates: A Divergent Synthesis of Aza-pyrimidinones and Imidazoles.

Organic Letters, 2015
A divergent cascade annulation has been developed using readily available vinyl azides and carbazates with a wide range of substituents. Vinyl azides were successfully applied as bifunctional partners to prepare aza-pyrimidinones via 6-ring closure with ...
Jiaan Shao, Xingyu Liu, K. Shu, P. Tang, Jing Luo, Wenteng Chen, Yongping Yu   +6 more
semanticscholar   +1 more source