Results 211 to 220 of about 4,994 (242)

ChemInform Abstract: Pyrimidinones. Part 1. 2‐Amino‐5‐halo‐6‐aryl‐4(3H)‐pyrimidinones.

Chemischer Informationsdienst, 1986
AbstractDie aus dem Halbester (I) zugänglichem Pyrimidinone (V) besitzen Interferon‐induzierende und antivirale Wirkung.
H. I. SKULNICK, S. D. WEED, E. E. EIDSON, H. E. RENIS, W. WIERENGA, D. A. STRINGFELLOW   +5 more
openaire   +1 more source

ChemInform Abstract: Photochemistry of 4‐Pyrimidinones. Part 7. Reaction of Dewar 4‐Pyrimidinone with Methylamine.

Chemischer Informationsdienst, 1982
AbstractDie Photolyse der Pyrimidinone (I) in flüssigem Methylamin (II) führt zu den offenkettigen Produkten (III), die bei der Chromatographie an Aluminiumoxid zu den Pyrimidinonen (IV) cyclisieren.
Y. HIRAI, H. KANMEI, T. YAMAZAKI, S. HIROKAMI   +3 more
openaire   +1 more source

Pyrimidinone Antibiotics—Heterocyclic Analogues with Improved Antibacterial Spectrum.

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Michael, Brands, Yolanda Cancho, Grande, Rainer, Endermann, Reinhold, Gahlmann, Jochen, Krüger, Siegfried, Raddatz   +5 more
openaire   +2 more sources

Antineoplastic properties of pyrimidinone interferon inducers

Advances in Enzyme Regulation, 1981
Abstract The interferon inducing, antiviral and antitumor activities of a new series of pyrimidinone compounds are compared and summarized in this report. An interesting split in mechanism of action appeared to exist in these compounds. One group represented by ABPP were very potent interferon inducing agents and the antiviral and antitumor activity ...
openaire   +2 more sources

Conformation of 1,2,3,4-tetrahydro-2-pyrimidinones

Chemistry of Heterocyclic Compounds, 1981
The conformation of a number of 1,2,3,4-tetrahydro-2-pyrimidinones with various substituents in the ring was established on the basis of the vicinal 3J34 constants found from the 1H NMR spectra of these compounds. It is shown that in solution rapid conformational transformations between the two possible “boat” conformations evidently occur.
�. �. Liepin'sh, E. L. Khanina, G. Ya. Dubur   +2 more
openaire   +1 more source

Pyrimidinones as reversible metaphase arresting agents

European Journal of Medicinal Chemistry, 1993
Abstract 5-Halo- N (1)-substituted 2(1 H )-pyrimidinones have the ability to cause reversible arrest of mitosis during metaphase. Highly active compounds have a heteroatom ( O , S or N ) in the β-position of the N (1)-carbon chain which is further substituted by an aryl group. In vitro data have been provided.
T Benneche, P Strande, R Oftebro, K Undheim   +3 more
openaire   +1 more source

Phenylation of pyrimidinones using diphenyliodonium salts

Journal of the Chemical Society, Perkin Transactions 1, 1999
Pyrimidinones 1 have been phenylated under basic conditions using diphenyliodonium salts, and the effect of substituents on the yield and regiochemistry has been studied.
Stig André Jacobsen, Synne Rødbotten, Tore Benneche   +2 more
openaire   +1 more source

Interferon Induction by 5-Halo-6-Phenyl Pyrimidinones

Journal of Interferon Research, 1980
The interferon inducing characteristics of a new series of 6-phenyl pyrimidinol compounds are described and compared against a previously identified pyrimidine, 2-amino-5-bromo-6-methyl-4-pyrimidinol (ABMP). Interestingly, a split in ability to induce interferon but not in vivo antiviral activity was observed in the newest compounds. One representative
D A, Stringfellow, H C, Vanderberg, S D, Weed   +2 more
openaire   +2 more sources

4-Azido-2-pyrimidinone Nucleosides and Related Chemistry

The Journal of Organic Chemistry, 1997
As a part of azide prodrug approach, we synthesized a 4-azido analog of ara-C (4) as a prodrug for ara-C. The compound 4 was obtained from 1-(beta-D-arabinofuranosyl)uracil (1) in three steps. At pH 7.0 and 11.0, a loss of UV absorption of the compound 4 was observed resulting from a transformation that was proved by identifying the transformed product
Lakshmi P., Kotra, PingPing, Wang, Michael G., Bartlett, Kirupa, Shanmuganathan, Zusheng, Xu, Sócrates, Cavalcanti, M. Gary, Newton, Chung K., Chu   +7 more
openaire   +2 more sources

Syntheses of trifluoromethylated pyridinones and pyrimidinones

The Journal of Organic Chemistry, 1990
Les syntheses s'effectuent via la reaction d'orthoformiates avec des enaminonitriles ou avec des ...
Len F. Lee, Y. Larry Sing
openaire   +1 more source