Results 241 to 250 of about 88,038 (326)

The Protein Kinase R Inhibitor C16 Alleviates Sepsis-Induced Acute Kidney Injury Through Modulation of the NF-κB and NLR Family Pyrin Domain-Containing 3 (NLPR3) Pyroptosis Signal Pathways

, 2020
Jialu Zhou, Fan Zhang, Hong‐Ru Lin, Minxue Quan, Yaqin Yang, Yanni Lv, Zongnan He, Yisong Qian   +7 more
openalex   +1 more source

The NLRP3 Inflammasome Regulates Orthodontic Tooth Movement

Orthodontics &Craniofacial Research, Volume 29, Issue 1, Page 134-143, February 2026.
ABSTRACT Objective The NLRP3 inflammasome is a damage sensor driving pyroptotic cell death during orthodontic tooth movement (OTM). Recent studies have revealed impaired one‐week OTM in mice lacking NLRP3. However, the relevance of NLRP3 during long‐term OTM remains unknown.
Lisa Latzko, Gerald Degenhart, Michael J. Blumer, Reinhard Gruber, Johannes Haybäck, Claudia Manzl, Adriano G. Crismani   +6 more
wiley   +1 more source

Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome

Nature Genetics, 2001
H. Hoffman, James L. Mueller, D. Broide, A. Wanderer, R. Kolodner   +4 more
semanticscholar   +1 more source

De novoCIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): A new member of the expanding family of pyrin-associated autoinflammatory diseases

, 2020
Ivona Aksentijevich, Miroslawa Nowak, Mustapha Mallah, Jae Jin Chae, Wendy T. Watford, Sigrun R. Hofmann, Leonard I. Stein, Ricardo Russo, Donald Goldsmith, Peter B. Dent, Helene F. Rosenberg, Frances Austin, Elaine F. Remmers, James E. Balow, Sergio D. Rosenzweig, Hirsh D. Komarow, Nitza G. Shoham, Geryl Wood, Janet Jones, Nadira Mangra, Hector Carrero, Barbara S. Adams, Terry L. Moore, Kenneth N. Schikler, Hal M. Hoffman, Daniel J. Lovell, Robert Lipnick, Karyl S. Barron, John J. O’Shea, Daniel L. Kastner, Raphaela Goldbach‐Mansky   +30 more
openalex   +1 more source

Phenotypical and Functional Characterization of Neutrophils in Two Pyrin-Associated Auto-inflammatory Diseases

, 2021
Bert Malengier‐Devlies, Mieke Metzemaekers, Mieke Gouwy, Erika Van Nieuwenhove, Albrecht Betrains, Maaike Cockx, Lotte Vanbrabant, Noëmie Pörtner, Jurgen Vercauteren, Lien De Somer, Sofie Struyf, Steven Vanderschueren, Ellen De Langhe, Paul Proost, Patrick Matthys, Carine Wouters   +15 more
openalex   +2 more sources

Neuroprotective effects of sinomenine and metformin in diabetic stroke: Role of NLRP3/caspase‐1 and mitophagy

Experimental Physiology, Volume 111, Issue 2, Page 489-500, 1 February 2026.
Abstract Type 2 diabetes mellitus (T2DM) significantly increases the risk and severity of cerebral ischaemia–reperfusion (IR) injury, yet effective neuroprotective treatments for diabetic stroke remain limited. This study explored whether a combination of sinomenine and metformin could offer enhanced neuroprotection in diabetic rats subjected to ...
Wendi Li, Yiying Fan, Shaik Althaf Hussain   +2 more
wiley   +1 more source

Gastrointestinal microbiota and inflammasomes interplay in health and disease: a gut feeling. [PDF]

Gut
De Luca R, Arrè V, Nardone S, Incerpi S, Giannelli G, Trivedi P, Anastasiadou E, Negro R.   +7 more
europepmc   +1 more source

Pyrin proteininin hücre göçü üzerine etkisinin incelenmesi

, 2020
Familial Mediterranean Fever is an autosomal recesively inherited, autoinflammatory disease characterized by inflammatory episodes. The prevalance of disease is 1:1000 in Turkey. The drug of choice for the disease is colchicine which both relieves the patient from episodes and prevents late complications like amyloidosis.
openaire   +1 more source

He-He-Shu-Yang formula alleviates liver fibrosis by inhibiting hepatic stellate cell activation <i>in vivo</i> and <i>in vitro</i>. [PDF]

World J Hepatol
Zeng FL, Shi MJ, Mo YS, Xiao HM, Xie YB, Chi XL.   +5 more
europepmc   +1 more source

Co-occurrence of autoimmune diseases and metabolic disorders in familial mediterranean fever patients: review of literature and case reports. [PDF]

Front Immunol
Chaaban A, Baalbaki N, Narch R, Eldawra E, Kobeissy PH, Ibrahim JN.   +5 more
europepmc   +1 more source