An update on PYRIN domain-containing pattern recognition receptors: from immunity to pathology [PDF]
Frontiers in Immunology, 2013 Cytosolic pattern recognition receptors (PRRs) sense a wide range of endogenous danger-associated molecular patterns (DAMPs) as well as exogenous pathogen-associated molecular patterns (PAMPs). In particular, Nod-like receptors (NLRs) containing a pyrin
Rojo A Ratsimandresy +2 more
doaj +4 more sources
Activation of nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 6 by Porphyromonas gingivalis regulates programmed cell death in epithelium [PDF]
Journal of Dental Sciences, 2023 Background/purpose: Gingival epithelial cells form a physiological barrier against bacterial invasion. Programmed cell death (PCD) regulated by pathogen precognition receptors (PRRs) lead to tissue destruction and is closely related to inflammatory ...
Jianru Liu +4 more
doaj +3 more sources
The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation [PDF]
Nature Communications, 2017 Excessive inflammasome activation leads to inflammatory diseases, but how inflammasomes are regulated by PYD-only adaptors is unclear. Here the authors show that the PYD-only protein POP2 inhibits both inflammasome priming and assembly by interfering ...
Anu Gangopadhyay +2 more
exaly +4 more sources
The PRY/SPRY domain of pyrin/TRIM20 interacts with β2-microglobulin to promote inflammasome formation [PDF]
Scientific Reports, 2021 Pyrin/TRIM20 is expressed in the neutrophils and monocytes/macrophages and regulates caspase-1 activation and interleukin-1β maturation. Although the mutations in the PRY/SPRY domain of pyrin cause familial Mediterranean fever (FMF), the mechanism of how
Sei Samukawa +3 more
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Small molecule inhibitor binds to NOD-like receptor family pyrin domain containing 3 and prevents inflammasome activation [PDF]
iScienceSummary: Despite recent advances in the mechanism of oxidized DNA activating NLRP3, the molecular mechanism and consequence of oxidized DNA associating with NLRP3 remains unknown.
Angela Lackner +9 more
doaj +2 more sources
The PYRIN domain is required for TLR4-mediated inflammation by PYHIN family members [PDF]
iScienceSummary: Innate immunity relies on pattern recognition receptors (PRRs) to detect threats, including pathogens and damage-associated molecular patterns (DAMPs) from damaged cells. IFI16 behaves as a DAMP and activates Toll-like receptor 4 (TLR4)-mediated
Andrea Iannucci +10 more
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The Pyrin Inflammasome in Health and Disease
Frontiers in Immunology, 2019 The pyrin inflammasome has evolved as an innate immune sensor to detect bacterial toxin-induced Rho guanosine triphosphatase (Rho GTPase)-inactivation, a process that is similar to the “guard” mechanism in plants. Rho GTPases act as molecular switches to
Oskar Schnappauf +2 more
exaly +3 more sources
Didymin, a natural flavonoid, relieves the progression of myocardial infarction via inhibiting the NLR family pyrin domain containing 3 inflammasome. [PDF]
Pharm Biol, 2022 Zhang Y, RuXian G.
europepmc +2 more sources
Nanocurcumin Decreases Nucleotide-Binding Oligomerization Domain-Like Receptor Family Pyrin Domain-Containing 3 Complex Expressions in An Experimental Testicular Torsion Model [PDF]
International Journal of Fertility and SterilityBackground: Testicular torsion is a surgical emergency leads to severe acute ischemia injuries, and may eventuallycause male infertility. The nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin domaincontaining3 (NLRP3 ...
Negar Malekshahi Fard +3 more
doaj +2 more sources
Activation of the High Mobility Group Box 1/Receptor for Advanced Glycation Endproducts /NOD-like Receptor Family Pyrin Domain-Containing 3 Axis Under Chronic Intermittent Hypoxia Induction Promotes the Progression of Atherosclerosis in ApoE-/- Mice. [PDF]
J Am Heart Assoc, 2023 Tan H +6 more
europepmc +3 more sources